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المؤلفون: Emily C, Soriano, M James, Lenhard, Jeffrey S, Gonzalez, Howard, Tennen, Amy K, Otto, Christine, Perndorfer, Biing-Jiun, Shen, Scott D, Siegel, Jean-Philippe, Laurenceau
المصدر: Psychosomatic medicine. 84(7)
مصطلحات موضوعية: Adult, Blood Glucose, Glycated Hemoglobin, Self Care, Diabetes Mellitus, Type 1, Glucose, Diabetes Mellitus, Type 2, Blood Glucose Self-Monitoring, Humans, Hypoglycemic Agents
الوصف: This study examined the dynamic, real-time associations between partner involvement in diabetes self-care and continuous glucose monitor (CGM) metrics in adults with type 2 diabetes.For 1 week, 63 participants wore Dexcom G4 CGMs and provided momentary reports of partner involvement in diabetes self-care five times per day. Dynamic structural equation models were used to estimate the reciprocal lagged effects of partner involvement on next-hour CGM metrics (and vice versa).Partner involvement predicted improved next-hour glucose control for five of six CGM metrics in analyses adjusted for time-varying covariates. The hour after partner involvement, the model predicted a 26.34 mg/dl decrease in glucose level (standardized β = -0.19), 30% greater odds of meeting target time in target range ( β = 0.07), 48% higher odds of target time below target range (TBR; β = 0.04; the only nonsignificant effect), 47% greater odds of target time above target range (β = 0.11), a 4.20 unit decrease in glucose standard deviation ( β = -0.19), and a 0.01 unit decrease in glucose coefficient of variation ( β = -0.08; all p values.05). There was less consistent support for the reverse pathway, with only two metrics significantly related to next-hour partner involvement: glucose level ( β = 0.15) and TBR ( β = 0.21), such that having higher levels and meeting target TBR were significantly predictive of next-hour partner involvement.This is the first study showing that partner involvement in daily diabetes management predicts short-term glucose control. More research is needed to understand how partners influence glycemic control and evaluate interventions that promote their involvement in diabetes care.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::ca1df0d17402fc6a2437c2dd0369b41cTest
https://pubmed.ncbi.nlm.nih.gov/35792706Test -
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المؤلفون: Yunge Fan, Moon‐Ho Ringo Ho, Biing‐Jiun Shen
المصدر: Applied psychology. Health and well-being.
مصطلحات موضوعية: Applied Psychology
الوصف: This study investigated whether loneliness would predict physical and mental health-related quality of life (HRQoL) over 9 months and examined whether medical adherence would mediate their associations in patients with coronary heart disease (CHD). The overall design is a three-wave longitudinal study. A sample of 255 outpatients with CHD was recruited from a community-based cardiac rehabilitation programme. Participants, with a mean age of 63 years, completed measures assessing loneliness, depression and physical and mental HRQoL at baseline. Medical adherence was assessed at 3 months, and physical and mental HRQoL were reassessed at 9 months. A total of 88% of participants reported moderate or high loneliness. Baseline loneliness predicted physical and mental HRQoL at 9 months after adjusting for baseline physical and mental HRQoL, respectively. The effects remained significant when depression was also adjusted. Medical adherence at 3 months partially mediated the associations of baseline loneliness with 9-month physical and mental HRQoL. Findings underline the necessity of assessing loneliness for CHD patients to promote long-term medical adherence and further improve physical and mental HRQoL.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f9521eb51bd399ceb35776e84feea4Test
https://pubmed.ncbi.nlm.nih.gov/36184794Test -
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المؤلفون: James M. Lenhard, Amy K. Otto, Scott D. Siegel, Christine Perndorfer, Emily C. Soriano, Jean-Philippe Laurenceau, Howard Tennen, Jeffrey S. Gonzalez, Sy Miin Chow, Biing Jiun Shen
المصدر: Ann Behav Med
مصطلحات موضوعية: Male, media_common.quotation_subject, 030209 endocrinology & metabolism, Glycemic Control, Type 2 diabetes, Psychological Distress, 03 medical and health sciences, 0302 clinical medicine, Diabetes management, Diabetes mellitus, medicine, Humans, Interpersonal Relations, Quality (business), Spouses, General Psychology, Aged, media_common, Glycemic, 030505 public health, Continuous glucose monitoring, business.industry, social sciences, Middle Aged, medicine.disease, Self Care, Psychiatry and Mental health, Distress, Diabetes Mellitus, Type 2, Self care, Female, Self Report, 0305 other medical science, business, Regular Articles, Clinical psychology
الوصف: Background Spouses often attempt to influence patients' diabetes self-care. Spousal influence has been linked to beneficial health outcomes in some studies, but to negative outcomes in others. Purpose We aimed to clarify the conditions under which spousal influence impedes glycemic control in patients with type 2 diabetes. Spousal influence was hypothesized to associate with poorer glycemic control among patients with high diabetes distress and low relationship quality. Methods Patients with type 2 diabetes and their spouses (N = 63 couples) completed self-report measures before patients initiated a 7-day period of continuous glucose monitoring. Mean glucose level and coefficient of variation (CV) were regressed on spousal influence, diabetes distress, relationship quality, and their two- and three-way interactions. Results The three-way interaction significantly predicted glucose variability, but not mean level. Results revealed a cross-over interaction between spousal influence and diabetes distress at high (but not low) levels of relationship quality, such that spousal influence was associated with less variability among patients with low distress, but more among those with high distress. Among patients with high distress and low relationship quality, a 1 SD increase in spousal influence predicted a difference roughly equivalent to the difference between the sample mean CV and a CV in the unstable glycemia range. Conclusions This was the first study to examine moderators of the link between spousal influence and glycemic control in diabetes. A large effect was found for glucose variability, but not mean levels. These novel results highlight the importance of intimate relationships in diabetes management.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ac062f605ea0d087ba8ec70923f4ffTest
https://doi.org/10.1093/abm/kaaa038Test -
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المؤلفون: Hung Yong Tay, Cindy Lim, Jonathan Jun Liang Tan, Biing Jiun Shen
المصدر: Journal of Clinical Psychology in Medical Settings. 27:677-685
مصطلحات موضوعية: Adult, Male, Sleep Wake Disorders, Psychometrics, Heart disease, Concurrent validity, Coronary Disease, Structural equation modeling, Pittsburgh Sleep Quality Index, Quality of life (healthcare), Surveys and Questionnaires, medicine, Humans, Aged, Aged, 80 and over, Singapore, business.industry, Reproducibility of Results, Middle Aged, medicine.disease, Sleep in non-human animals, Confirmatory factor analysis, Clinical Psychology, Health psychology, Quality of Life, Female, Factor Analysis, Statistical, business, Clinical psychology
الوصف: Research on the underlying structure of sleep measures in patients with coronary heart disease (CHD) is lacking. Existing research on sleep and health outcomes primarily focused on only one dimension of sleep (e.g., sleep duration), leaving other aspects unexamined. To address this gap, this study examined the measurement structure of Pittsburgh Sleep Quality Index (PSQI) and its associations with health-related quality of life among CHD patients. Participants were 167 CHD patients from a cardiac wellness program. Confirmatory factor analysis revealed that the two-factor structure with sleep efficiency and perceived sleep quality best fitted the data. Concurrent validity analyses with structural equation modeling showed that, when considered simultaneously, perceived sleep quality, but not sleep efficiency, was significantly associated with emotional, physical, and social quality of life. Findings demonstrated that the PSQI consists of two moderately correlated factors that are differentially associated with separate health domains in cardiac patients.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf44b1adb109c21ff7b06e2d7917a483Test
https://doi.org/10.1007/s10880-019-09652-0Test -
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المؤلفون: Jonathan Jun Liang Tan, Biing Jiun Shen, Yue Xu, Hung Yong Tay
المصدر: Behavioral medicine (Washington, D.C.). 48(4)
مصطلحات موضوعية: Gerontology, Sleep Wake Disorders, Heart disease, media_common.quotation_subject, Coronary Disease, 03 medical and health sciences, Social support, 0302 clinical medicine, Quality of life (healthcare), Sleep Initiation and Maintenance Disorders, medicine, Humans, Quality (business), In patient, 030212 general & internal medicine, Applied Psychology, media_common, 030505 public health, business.industry, Social Support, biochemical phenomena, metabolism, and nutrition, medicine.disease, Sleep in non-human animals, Coronary heart disease, Poor sleep, Psychiatry and Mental health, Sleep Quality, Quality of Life, 0305 other medical science, business, Sleep
الوصف: Although sleep problems are common among patients with coronary heart disease (CHD), there is a lack of prospective research examining its influence on health consequences over time. This study investigated whether poor sleep quality predicted patients' decline in physical health functioning over 6 months and whether social support buffered its detrimental effect. Participants were 185 patients with CHD, who completed measures of sleep, psychosocial characteristics, and physical health functioning at baseline and 6 months. Hierarchical regression analyses were conducted to examine whether global sleep index and its subscales, including sleep efficiency, perceived sleep quality, and daily disturbances (sleep disturbances and daytime dysfunction), predicted the decline of physical health functioning at 6 months. Social support was examined for its moderating effect in buffering the negative influence of poor sleep quality on physical health functioning over 6 months. Findings showed that poorer global sleep index, especially subscales of daily disturbances and lower sleep efficiency, significantly predicted greater decline of physical health functioning at 6 months, even after adjusting for covariates, including baseline functioning and depression. Moreover, social support was found to buffer the detrimental impact of poor sleep quality, especially low sleep efficiency, on 6-month physical health functioning. Findings suggest that improving sleep quality for patients with CHD may be promising to facilitate their long-term health maintenance.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f396c5262245d0489c521d23bcafe3Test
https://pubmed.ncbi.nlm.nih.gov/33750280Test -
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المؤلفون: Hung Yong Tay, Biing Jiun Shen, Yunge Fan
المصدر: British journal of health psychologyREFERENCES. 26(3)
مصطلحات موضوعية: medicine.medical_specialty, Longitudinal study, Medication adherence, Coronary Disease, Anxiety, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Longitudinal Studies, Applied Psychology, Disease prognosis, Depression (differential diagnoses), 030505 public health, business.industry, Depression, Mean age, General Medicine, Middle Aged, Coronary heart disease, Distress, medicine.symptom, 0305 other medical science, business, Stress, Psychological
الوصف: OBJECTIVES Although effective medical treatments have proved to successfully improve prognoses and outcomes of patients with coronary heart disease (CHD), low adherence to treatments is still common among patients. Deleterious impact of psychological distress on medical adherence has been recognized; however, few studies examined the influence of change in psychological distress on attenuation in adherence. This study investigated whether three common manifestations of distress (depression, anxiety, and perceived stress) and their changes predicted decline in medical adherence among CHD patient over 9 months. DESIGN A three-wave longitudinal study. METHODS Participants were 255 CHD patients with a mean age of 63 years. Psychological distress, medication adherence, and specific treatment adherence were assessed at baseline, 3 months, and 9 months. Hierarchical regression analyses were conducted to examine the influences of psychological distress on medical adherence over 9 months. All models were adjusted for baseline medication or specific adherence, demographic, and medical covariates. RESULTS Baseline depression and its changes over time significantly predicted greater decline in both medication adherence (βs = .15-.20, ps
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9076f427cb956ccbd380ff99d4da727Test
https://pubmed.ncbi.nlm.nih.gov/33382184Test -
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المؤلفون: Uta Maeda, Biing Jiun Shen
المساهمون: School of Social Sciences
المصدر: Annals of Behavioral Medicine. 52:613-619
مصطلحات موضوعية: Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, 03 medical and health sciences, Social support, Sex Factors, 0302 clinical medicine, Psychology [Social sciences], Internal medicine, medicine, Humans, Psychology, 030212 general & internal medicine, Disease management (health), Prospective cohort study, General Psychology, Depression (differential diagnoses), Heart Failure, Self-efficacy, Depression, business.industry, Age Factors, Social Support, Middle Aged, medicine.disease, Self Efficacy, Psychiatry and Mental health, Heart failure, Medical Adherence, Patient Compliance, Marital status, Female, Self Report, business, Psychosocial
الوصف: Background Poor adherence to medical regimens is a serious problem that interferes with heart failure (HF) patients’ disease management and contributes to poor clinical outcomes. Few prospective studies have examined the psychosocial predictors of adherence over time in HF patients. Purpose This study examined the influences of depression, self-efficacy, social support, and their changes on self-reported medical adherence over 6 months in HF patients. Methods Participants were 252 HF outpatients, among whom 168 completed follow-up assessments. Hierarchical multiple regression analyses were conducted to examine whether psychosocial variables and their changes prospectively predicted adherence at 6 months, after adjusting for baseline adherence, age, gender, ethnicity, marital status, education, HF severity, medical comorbidity, and mental health treatment. Results Baseline self-efficacy (β = .22, p < .05), increase in self-efficacy (β = .34, p < .001), and decrease in depression (β = –.15, p = .05) predicted improved adherence over 6 months, but social support did not. In the combined model that included all significant psychosocial predictors from previous analyses, baseline self-efficacy (β = .37, p = .001) and its increase (β = .35, p < .001) emerged as independent predictors of improved adherence at 6 months. Conclusions Promoting self-efficacy and reducing depressive symptoms may be promising targets of behavioral interventions to facilitate long-term disease management in HF patients.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abda4c53dd8e585fa3e3df8450e9f60aTest
https://doi.org/10.1093/abm/kay003Test -
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المؤلفون: Yue Xu, Stacy Eisenberg, Biing Jiun Shen
المصدر: International Journal of Behavioral Medicine. 24:83-91
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, Logistic regression, 03 medical and health sciences, Social support, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Applied Psychology, Depression (differential diagnoses), Aged, Heart Failure, Inflammation, Univariate analysis, Marital Status, biology, Depression, C-reactive protein, Social Support, Middle Aged, C-Reactive Protein, biology.protein, Marital status, Female, Psychology, Psychosocial, Clinical psychology
الوصف: Few studies have examined the interplay between psychosocial and physiological variables in prediction of mortality in heart failure (HF) patients. This study investigated the prospective influence of marital status, social support, depression, and C-reactive protein (CRP) on the mortality of patients with chronic HF. In addition, it examined whether there was a mediating relationship between social support and marital status and whether depression and inflammation influenced one another to predict mortality of HF patients. The participants were 220 HF patients, among whom 48 were deceased over an average of 4.60 years. A number of psychosocial and biomedical variables were examined for their associations with mortality and their relationships between each other in hierarchical logistic regression analyses. After adjusting for New York Heart Association (NYHA) class, age, and gender, being unmarried predicted mortality (OR = 2.80, p = 0.004), whereas perceived social support did not. Higher CRP was not associated with depression, and it independently predicted mortality (OR = 1.92, p = 0.030). Depression predicted mortality only in the univariate analysis (OR = 1.02, p = 0.030), but the association was no longer significant either after removing somatic items or after adjusting for covariates. In the combined multivariate model, marital status (OR = 2.20, p = 0.047), CRP (OR = 1.91, p = 0.035), and NYHA class (OR = 2.41, p = 0.001) independently predicted mortality. Monitoring chronic HF patients who are unmarried, with elevated inflammation, or in higher NYHA class may help identify those at greater mortality risk to implement targeted intervention.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b214c2e0b78cd92c7fcefa0a0b11b7Test
https://doi.org/10.1007/s12529-016-9579-2Test -
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المؤلفون: Matthew J. Hardman, Biing Jiun Shen, Irena Pastar, Marjana Tomic-Canic, Loretta Vileikyte, Robert S. Kirsner, Andrew J.M. Boulton
المصدر: Diabetes. 67
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Creatinine, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, medicine.disease, Gastroenterology, Diabetic foot, Proinflammatory cytokine, 03 medical and health sciences, Steroid hormone, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Glucocorticoid receptor, chemistry, Internal medicine, Internal Medicine, medicine, Immunohistochemistry, Biomarker (medicine), Steroid 11-beta-hydroxylase, business
الوصف: An urgent need exists to identify predictive biomarkers to guide management of diabetic foot ulcers (DFUs). The steroid hormone, cortisol, is elevated in chronic inflammatory states and its pathogenic role and/or prognostic role for poor outcomes across a range of diseases has been suggested. However, the role of cortisol in DFUs is not well understood and the significance of local, tissue-specific cortisol regulation in DFUs remains unclear. We performed a multi-center study of 63 well vascularized, superficial neuropathic, non-infected DFU subjects receiving standard care and used wound biopsy obtained at baseline study to quantify expression levels (via immunohistochemistry) of the major cortisol synthesis enzymes CYP11B1 and 11BHSD1, and other inflammatory cytokines. Subjects were predominantly men in their late-fifties (58±10 years) with poor glycemic control (HbA1C 8.9±2.3%); while hemoglobin (12.6±1.8g/dl), creatinine (1.27±0.5mg/dl) and albumin (4.1±0.42g/dl) were within the normal range. We found high cutaneous levels of CYP11B1 strongly linked to failure to heal DFUs at 6 weeks (p≤0.016), while 11BHSD1 did not correlate with healing (p=0.351). In the logistic regression analyses controlling for demographics and disease characteristics, higher levels of CYP11B1 (10-based log-transformed) were predictive of non-healing of DFU at 6 weeks (OR = 6.83, p =.010). High local tissue levels of the pro-inflammatory TNFalpha were also significantly associated with lack of ulcer healing (p≤0.019). This observation is consistent with reports that TNFalpha is essential for local induction of CYP11B1. In turn, local induction of CYP11B1 and subsequent induced tissue cortisol levels activate membranous glucocorticoid receptor triggering PLC/PKC/GSK-3beta/beta-catenin pathway that inhibits healing. Taken together, these data suggest CYP11B1 is a potential predictive biomarker for DFU outcomes, and may serve as a future target for therapeutic interventions. Disclosure L. Vileikyte: None. B. Shen: None. I. Pastar: None. A.J. Boulton: None. R. Kirsner: None. M. Tomic-Canic: None. M. Hardman: None.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ab919dd6d107d6cccaf4d0fecb8b63aaTest
https://doi.org/10.2337/db18-641-pTest
