Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risknovelty and significance
التفاصيل البيبلوغرافية
العنوان:
Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risknovelty and significance
Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/meanx100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination = 5 points), and cognitive deterioration (drop of >1 point per year or decline to
