Clinical experience in anti-synthetase syndrome: a monocentric retrospective analytical study
| العنوان: | Clinical experience in anti-synthetase syndrome: a monocentric retrospective analytical study |
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| المؤلفون: | Gester Fanny, Louis Renaud, Von Frenckell Christian, Quentin Maloir, Guiot Julien, Seidel Laurence |
| المصدر: | Acta Clinica Belgica. 77:624-630 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Treatment response, Autoimmune Diseases, Pulmonary function testing, Cohort Studies, Ligases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Autoantibodies, Retrospective Studies, Bronchiectasis, business.industry, Interstitial lung disease, Autoantibody, Retrospective cohort study, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, Radiological weapon, Cohort, Female, business |
| الوصف: | OBJECTIVES Anti-synthetase syndrome (ASS) is a rare auto-immune disorder combining autoantibodies and specifics clinical manifestations. One of the particularities of the ASS is the pleiomorphic radiological presentation seen at the initial work-up. Evaluating treatment response can also be challenging and requires a specific clinical, functional, biological and radiological monitoring. For these reasons is fundamental to identify specific radiological and clinical features of ASS to improve diagnosis and therapeutic approach. METHODS We retrospectively studied all patients suffering from ASS in CHU of Liège from 2008 to 2019. The diagnosis of ASS was made according to ERS's criteria. We analyzed clinical features, pulmonary function test (PFT), computed tomography (CT), and longitudinal evolution with regard to their treatments. RESULTS In the whole cohort of 30 patients, we identified 19 anti-JO1, 5 anti-PL12 & 6 anti-PL7. The sex-ratio is slightly in favor of male. Interestingly PL-12 syndrome was present in younger patients than those with others antibodies (mean age 39,8 vs 53,1 (JO1) & 73,3 (PL7) (p |
| تدمد: | 2295-3337 1784-3286 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e1a9263ead4da33d95aa105fbbb5c8Test https://doi.org/10.1080/17843286.2021.1925818Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9e1a9263ead4da33d95aa105fbbb5c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22953337 17843286 |
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