Cell death and survival through the endoplasmic reticulum-mitochondrial axis
| العنوان: | Cell death and survival through the endoplasmic reticulum-mitochondrial axis |
|---|---|
| المؤلفون: | Tomás Gutierrez, Clara Quiroga, Mario Chiong, Camila López-Crisosto, Jovan Kuzmicic, Roberto Bravo-Sagua, Thomas G. Gillette, Andrea E. Rodriguez, Jessica Díaz-Elizondo, Beverly A. Rothermel, Sergio Lavandero |
| المصدر: | Scopus-Elsevier CURRENT MOLECULAR MEDICINE Artículos CONICYT CONICYT Chile instacron:CONICYT |
| مصطلحات موضوعية: | Cell Survival, Biology, Endoplasmic Reticulum, Membrane Fusion, Biochemistry, Article, symbols.namesake, Animals, Humans, Endomembrane system, Molecular Biology, Cytoskeleton, Cellular compartment, Calcium signaling, Endoplasmic reticulum membrane, Cell Death, Endoplasmic reticulum, STIM1, Mitochondrial Turnover, General Medicine, Golgi apparatus, Membrane contact site, Mitochondria, Cell biology, Organelle Size, symbols, Molecular Medicine, Calcium, Signal Transduction |
| الوصف: | The endoplasmic reticulum has a central role in biosynthesis of a variety of proteins and lipids. Mitochondria generate ATP, synthesize and process numerous metabolites, and are key regulators of cell death. The architectures of endoplasmic reticulum and mitochondria change continually via the process of membrane fusion, fission, elongation, degradation, and renewal. These structural changes correlate with important changes in organellar function. Both organelles are capable of moving along the cytoskeleton, thus changing their cellular distribution. Numerous studies have demonstrated coordination and communication between mitochondria and endoplasmic reticulum. A focal point for these interactions is a zone of close contact between them known as the mitochondrial–associated endoplasmic reticulum membrane (MAM), which serves as a signaling juncture that facilitates calcium and lipid transfer between organelles. Here we review the emerging data on how communication between endoplasmic reticulum and mitochondria can modulate organelle function and determine cellular fate. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772bcc4dd1f115781bcf8bed1c973ef5Test http://www.scopus.com/inward/record.url?eid=2-s2.0-84874863991&partnerID=MN8TOARSTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....772bcc4dd1f115781bcf8bed1c973ef5 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |