Inappropriate expression of human transforming growth factor (TGF)-α in the uterus of transgenic mouse causes downregulation of TGF-β receptors and delays the blastocyst-attachment reaction
| العنوان: | Inappropriate expression of human transforming growth factor (TGF)-α in the uterus of transgenic mouse causes downregulation of TGF-β receptors and delays the blastocyst-attachment reaction |
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| المؤلفون: | J Wang, Sudhansu K. Dey, Hyunjung Jade Lim, Sanjoy K. Das, M BazDresch, Bibhash C. Paria |
| المصدر: | Journal of Molecular Endocrinology. 18:243-257 |
| بيانات النشر: | Bioscientifica, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Genetically modified mouse, EGF Family of Proteins, medicine.medical_specialty, TGF alpha, Time Factors, Stromal cell, Down-Regulation, Gene Expression, Mice, Transgenic, Amphiregulin, Mice, Endocrinology, Pregnancy, Transforming Growth Factor beta, Internal medicine, medicine, Animals, Humans, Decidual cells, Embryo Implantation, Blastocyst, Growth Substances, Promoter Regions, Genetic, Molecular Biology, In Situ Hybridization, Glycoproteins, Chemistry, Uterus, Transforming Growth Factor alpha, Cell biology, medicine.anatomical_structure, Transforming growth factor, beta 3, Intercellular Signaling Peptides and Proteins, Female, Metallothionein, Receptors, Transforming Growth Factor beta, Signal Transduction, Transforming growth factor |
| الوصف: | In the mouse, the initiation of the attachment reaction between the blastocyst trophectoderm and luminal epithelium of the receptive uterus occurs in the evening (2200-2300 h) of day 4 of pregnancy (day 1=vaginal plug) and is followed by proliferation and differentiation of stromal cells into decidual cells at the sites of blastocyst attachment. This investigation demonstrates that an inappropriate expression of the human transforming growth factor α (hTGF-α) transgene in the uterus under the direction of a mouse metallothionein-I promoter downregulates uterine expression of TGF-β receptor subtypes and delays the initiation of implantation (attachment reaction) resulting in delayed parturition. This delay in the attachment reaction is accompanied by deferred uterine expression of amphiregulin. The results suggest that a coordinated 'cross-talk' between the signaling pathways executed by epidermal growth factor-like growth factors and TGF-βs is important for the normal implantation process. |
| تدمد: | 1479-6813 0952-5041 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90515adf2f2d201fa18bedbe4abf1671Test https://doi.org/10.1677/jme.0.0180243Test |
| رقم الانضمام: | edsair.doi.dedup.....90515adf2f2d201fa18bedbe4abf1671 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14796813 09525041 |
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