Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma
| العنوان: | Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma |
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| المؤلفون: | Clelia Tiziana Storlazzi, Antonio Giovanni Solimando, Vanessa Desantis, Ilaria Saltarella, Assunta Melaccio, Roberto Ria, Angelo Vacca, Maria Antonia Frassanito, Aurelia Lamanuzzi, Maria Addolorata Mariggiò |
| المصدر: | Cells Cells, Vol 9, Iss 1, p 167 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, CD38 antigen, Drug resistance, Review, CD38, Monoclonal antibody, Dara, 03 medical and health sciences, 0302 clinical medicine, Phagocytosis, Medicine, Animals, Humans, Cytotoxicity, lcsh:QH301-705.5, Multiple myeloma, Antibody-dependent cell-mediated cytotoxicity, drug resistance, business.industry, Antibody-Dependent Cell Cytotoxicity, Daratumumab, Antibodies, Monoclonal, General Medicine, medicine.disease, daratumumab, ADP-ribosyl Cyclase 1, multiple myeloma, 030104 developmental biology, lcsh:Biology (General), Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, business |
| الوصف: | Daratumumab (Dara) is the first-in-class human-specific anti-CD38 mAb approved for the treatment of multiple myeloma (MM). Although recent data have demonstrated very promising results in clinical practice and trials, some patients do not achieve a partial response, and ultimately all patients undergo progression. Dara exerts anti-MM activity via antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC), and immunomodulatory effects. Deregulation of these pleiotropic mechanisms may cause development of Dara resistance. Knowledge of this resistance may improve the therapeutic management of MM patients. |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d127fa37e2641dc22d767d07f6600e24Test https://pubmed.ncbi.nlm.nih.gov/31936617Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d127fa37e2641dc22d767d07f6600e24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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