المؤلفون: Jing Yang, Jianhua Yan, Cheng Zhang, Shanqin Li, Manhua Yuan, Chunge Zhang, Chenguang Shen, Yang Yang, Lifeng Fu, Guanlong Xu, Weifeng Shi, Zhenghai Ma, Ting Rong Luo, Yuhai Bi

المصدر: Emerging microbesinfections. 12(1)

مصطلحات موضوعية: China, Farms, Epidemiology, Immunology, General Medicine, Cat Diseases, Microbiology, Mice, Infectious Diseases, Hemagglutinins, Orthomyxoviridae Infections, Virology, Influenza in Birds, Drug Discovery, Influenza, Human, Cats, Influenza A Virus, H9N2 Subtype, Animals, Humans, Parasitology, Female, Chickens, Phylogeny

الوصف: During an investigation in October 2018, two people with diarrhoea, mild abdominal pain, and mild arthralgia symptoms in Guangxi, China, were identified as infected by H9N2 avian influenza virus (AIV). Four H9N2 AIVs were isolated from one of two patients, a pet cat, and a dead chicken (two respective isolates from its lung and kidney tissues) bred by the patients at a backyard farm. Epidemiological investigation indicated that the newly bought chicken died first, and clinical syndromes appeared subsequently in the two owners and one cat. Furthermore, the two individuals possessed high H9N2-specific hemagglutination inhibition and microneutralization antibodies. Shared nucleotide sequence identity (99.9% - 100%) for all genes was detected in the four H9N2 isolates, and hemagglutinin (HA) T138A located on the receptor binding domain (RBD), resulted from nucleotide polymorphisms that were exclusively found in the isolate from the female patient. Moreover, HA K137N on the RBD was found in isolates from these three host species. Importantly, these four H9N2 isolates presented an exclusive binding preference for the human-type receptor (α2-6-SA), and could replicate and cause pathological changes in mice. Phylogenetic analyses showed that these four isolates clustered together and belonged to clade C1.2, lineage Y280. In addition, H9N2 viruses of human origin are genetically divergent and interspersed with the widespread poultry-origin H9N2 AIVs. All these results indicate a high risk of H9N2 AIVs in public health, and effective prevention and control measures against H9N2 AIVs should be considered and performed for both animal and human health.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b5d8bdb17a67d3fa4b7f8b3b3f78dbTest
https://pubmed.ncbi.nlm.nih.gov/36328956Test

المؤلفون: Dilihuma Aji, Nana Chang, Cheng Zhang, Fei Du, Juan Li, Fengze Yun, Weifeng Shi, Yuhai Bi, Zhenghai Ma

المصدر: Avian Diseases. 65

مصطلحات موضوعية: China, Ducks, General Immunology and Microbiology, Food Animals, Influenza in Birds, Influenza A Virus, H9N2 Subtype, Animals, Animal Science and Zoology, Influenza A Virus, H5N2 Subtype, Phylogeny, Poultry, Reassortant Viruses

الوصف: Live poultry markets (LPMs) play a key role in reassorting and spreading avian influenza viruses (AIVs). In 2018, four strains of H5N2 AIVs were isolated from domestic ducks (Rápida aparición de los virus de influenza aviar altamente patógenos H5N2 reacomodados 2.3.4.4b en un mercado de aves vivas en Xinjiang, en el noroeste de China. Los mercados de aves vivas desempeñan un papel clave en el reacomodo y en la propagación de los virus de la influenza aviar. En el año 2018, se aislaron cuatro cepas del virus de influenza aviar H5N2 de patos domésticos durante los procedimientos de vigilancia para influenza aviar en mercados de aves vivas en Urumqi, Xinjiang, China. Todos los segmentos de genes de los aislados se amplificaron mediante transcripción reversa y PCR y se secuenciaron; posteriormente, se analizaron las mutaciones genéticas virales, el reacomodamiento y el origen. Se observaron altas identidades de nucleótidos entre cada gene de los aislados, lo que indica un ancestro común. Todos los genes de hemaglutinina (HA) de los aislamientos se clasificaron en el clado 2.3.4.4b; los genes de la proteína HA, la proteína de matriz (MP) y la proteína no estructural (NS) se agruparon junto con los virus de influenza altamente patógenos locales H5N6 identificados en el mismo mercado de aves vivas de Urumqi en julio de 2017; la albúmina de la neuraminidasa, las proteínas básicas de la polimerasa 1 y 2, la proteína ácida de la polimerasa y los genes de la proteína de la nucleocápsida (NA, PB1, PB2, PA y NP) tenían relaciones filogenéticas cercanas con virus de influenza locales H9N2 identificados en el mismo mercado de aves vivas de septiembre a octubre del 2018. Hubo múltiples aminoácidos básicos presentes en el sitio de disociación de la proteína HA, que se asoció con virus de influenza de alta patogenicidad. Estos resultados indicaron que los virus de influenza de alta patogenicidad H5N2 del clado reacomodado 2.3.4.4b se generaron rápidamente a partir del reacomodo entre los virus de influenza H5N6 y H9N2 en el mercado de aves vivas local de Urumqi en el año 2018.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4be9a28283c822008b9cbb622c8401aTest
https://doi.org/10.1637/aviandiseases-d-21-00075Test

المؤلفون: Yuhai Bi, George F. Gao, Yanan Cui, Samantha Lycett, Yongchun Yang, Jian Cao, Houhui Song, Xiaodu Wang, Chunge Zhang, Lu Lu, Weifeng Shi, Juan Li, Hong Zhou, Xue Yao, Hui Dong, Wenjun Liu

المصدر: Emerging Microbes & Infections
article-version (VoR) Version of Record
Li, J, Zhang, C, Cao, J, Yang, Y, Dong, H, Cui, Y, Yao, X, Zhou, H, Lu, L, Lycett, S, Wang, X, Song, H, Liu, W, Gao, G F, Shi, W & Bi, Y 2021, ' Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China ', Emerging Microbes and Infections, pp. 1-752 . https://doi.org/10.1080/22221751.2021.1968317Test

مصطلحات موضوعية: China, migratory birds, Letter, Epidemiology, Immunology, re-emergence, Zoology, Animals, Wild, Biology, Microbiology, Communicable Diseases, Emerging, Poultry, Disease Outbreaks, Birds, H5N8, Virology, Drug Discovery, Animals, Influenza A Virus, H5N8 Subtype, Phylogeny, Poultry Diseases, Phylogenetic tree, clade 2.3.4.4b, virus diseases, General Medicine, biology.organism_classification, Infectious Diseases, Highly pathogenic avian influenza virus (HPAIV), Highly Pathogenic Avian Influenza Virus, Whooper swan, Influenza in Birds, Parasitology, Reassortant Viruses

الوصف: In mid-November 2020, deaths of whooper swan were reported in the Yellow River Reservoir Area, China. In the present study, we describe the genetic characterizations and phylogenetic relationships of four clade 2.3.4.4b H5N8 highly avian influenza viruses (HPAIVs) identified from a sick whooper swan and environmental samples collected in the Yellow River Reservoir Area in late November 2020. They were closely related to recent H5Nx HPAIVs causing outbreaks in Eurasia in the 2020-2021 influenza season, suggesting these isolates might be imported into China via migratory birds. The newly identified H5N8 HPAIVs possessed Q226 and G228 (H3 numbering), indicating that they prefer to avian-like receptors. However, they had three mutations falling within known antigenic regions, including T144A in antigenic region A, T192I in antigenic region B, and N240D in antigenic region D. Our study highlights the risk of the rapid global spread of H5N8 HPAIVs and the necessity for continuous monitoring of avian influenza viruses in wild birds.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a58d15e3e3a3edea7807ab7ce95c89Test
https://pubmed.ncbi.nlm.nih.gov/34392820Test

المؤلفون: Nana Chang, Cheng Zhang, Xindi Mei, Fei Du, Juan Li, Lijuan Zhang, Han Du, Fengze Yun, Dilihuma Aji, Weifeng Shi, Yuhai Bi, Zhenghai Ma

المصدر: Preventive veterinary medicine. 199

مصطلحات موضوعية: China, Food Animals, Influenza in Birds, Influenza A Virus, H9N2 Subtype, Animals, Animal Science and Zoology, Animals, Wild, Influenza A Virus, H5N8 Subtype, Phylogeny, Poultry Diseases

الوصف: In 2016, H5N8 avian influenza viruses of clade 2.3.4.4b were detected at Qinghai Lake, China. Afterwards, the viruses of this clade rapidly spread to Asia, Europe, and Africa via migratory birds, and caused massive deaths in poultry and wild birds globally. In this study, four H5N8 isolates (abbreviated as 001, 002, 003, and 004) were isolated from the live poultry market in Xinjiang in 2017. Phylogenetic analysis showed that the hemagglutinin genes of the four isolates belonged to clade 2.3.4.4b, while the viral gene segments were from multiple geographic origins. For 002, the polymerase acidic gene had the highest sequence homology (99.55 %) with H5N8 virus identified from green-winged teal in Egypt in 2016, and the remaining genes exhibited the highest sequence homologies (99.18-100 %) with those of H5N8 viruses isolated from domestic duck sampled in Siberia in 2016. The polymerase basic 1 gene clustered together with H5N8 virus identified from painted stork of India in 2016, and the remaining genes had relatively close genetic relationships with H5N8 viruses identified from the duck of Siberia in 2016 and turkey in Italy in 2017. For the other three isolates, the nucleoprotein gene of 001 had the highest sequence homology (98.82 %) and relatively close genetic relationship with H9N2 viruses identified from poultry in Vietnam and Cambodia in 2015-2017, and all the remaining genes had the highest sequence homologies (99.18 %-99.58 %) and relatively close genetic relationships with H5N8 viruses identified from poultry and waterfowl sampled in African countries in 2017 and swan sampled in China in 2016. Multiple basic amino acids were observed at cleavage sites in the hemagglutinin proteins of the H5N8 isolates, indicating high pathogenicity. In addition, the L89V, G309D, R477G, I495V, A676T and I504V mutations in the polymerase basic 2 protein, N30D and T215A mutations in the matrix 1 protein, P42S mutation, and 80-84 amino acid deletion in the nonstructural 1 protein were detected in all isolates. These mutations were associated with increased virulence and polymerase activity in mammals. Therefore, our results indicate that the H5N8 isolates involved multiple introductions of reassorted viruses, and also revealed that the wetlands of Northern Tianshan Mountain may play a key role in H5N8 AIVs disseminating among Central China, the Eurasian continent, and East African Countries.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e78aec5e05d03074b88e24e98f9d994Test
https://pubmed.ncbi.nlm.nih.gov/34959041Test

المؤلفون: Nana Chang, Yuhai Bi, Xindi Mei, Weifeng Shi, Dilihuma Aji, Zhenghai Ma, Qian Zhang, Cheng Zhang, Juan Li

المصدر: Journal of Veterinary Science

مصطلحات موضوعية: China, 040301 veterinary sciences, animal diseases, Reassortment, Sequence alignment, Animals, Wild, Biology, medicine.disease_cause, 0403 veterinary science, Birds, 03 medical and health sciences, Virology, medicine, Animals, Clade, Gene, Phylogeny, 030304 developmental biology, 0303 health sciences, General Veterinary, Phylogenetic tree, Virulence, Whole Genome Sequencing, Inoculation, poultry, Embryonated, Highly pathogenic avian influenza virus, virus diseases, 04 agricultural and veterinary sciences, H5N6, Influenza A virus subtype H5N1, wild bird, Influenza A virus, reassortant, Animals, Domestic, Influenza in Birds, Original Article, Reassortant Viruses

الوصف: Background The H5 avian influenza viruses (AIVs) of clade 2.3.4.4 circulate in wild and domestic birds worldwide. In 2017, nine strains of H5N6 AIVs were isolated from aquatic poultry in Xinjiang, Northwest China. Objectives This study aimed to analyze the origin, reassortment, and mutations of the AIV isolates. Methods AIVs were isolated from oropharyngeal and cloacal swabs of poultry. Identification was accomplished by inoculating isolates into embryonated chicken eggs and performing hemagglutination tests and reverse transcription polymerase chain reaction (RT-PCR). The viral genomes were amplified with RT-PCR and then sequenced. The sequence alignment, phylogenetic, and molecular characteristic analyses were performed by using bioinformatic software. Results Nine isolates originated from the same ancestor. The viral HA gene belonged to clade 2.3.4.4B, while the NA gene had a close phylogenetic relationship with the 2.3.4.4C H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated from shoveler ducks in Ningxia in 2015. The NP gene was grouped into an independent subcluster within the 2.3.4.4B H5N8 AIVs, and the remaining six genes all had close phylogenetic relationships with the 2.3.4.4B H5N8 HPAIVs isolated from the wild birds in China, Egypt, Uganda, Cameroon, and India in 2016-2017, Multiple basic amino acid residues associated with HPAIVs were located adjacent to the cleavage site of the HA protein. The nine isolates comprised reassortant 2.3.4.4B HPAIVs originating from 2.3.4.4B H5N8 and 2.3.4.4C H5N6 viruses in wild birds. Conclusions These results suggest that the Northern Tianshan Mountain wetlands in Xinjiang may have a key role in AIVs disseminating from Central China to the Eurasian continent and East African.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac482fa4616c48e9bdf30f6b3e05c13Test
https://pubmed.ncbi.nlm.nih.gov/34170087Test

المؤلفون: Gaiping Zhang, Baoli Zhu, Jian Cao, Na Lyu, Yanan Wang, Sufang Ma, Yongfei Hu, Xiaofeng Song, William J. Liu, Fei Liu, Yuhai Bi, George F. Gao, Aiping Wang, Zewu Zhang

المصدر: Environment International, Vol 153, Iss, Pp 106534-(2021)

مصطلحات موضوعية: Veterinary medicine, China, 010504 meteorology & atmospheric sciences, Antimicrobial resistant bacteria, Colistin resistance, 010501 environmental sciences, Biology, 01 natural sciences, Poultry, Antibiotic resistance, Live poultry market workers, Tigecycline resistance, Occupational Exposure, Drug Resistance, Bacterial, Animals, Humans, GE1-350, Microbiome, Feces, 0105 earth and related environmental sciences, General Environmental Science, Farmers, business.industry, Drug Resistance, Microbial, Poultry farming, Control subjects, Resistome, Anti-Bacterial Agents, Environmental sciences, Antibiotic resistome, Genes, Bacterial, Metagenomics, business, Chickens, Antibiotic resistance genes

الوصف: Background Poultry farms and LPMs are a reservoir of antimicrobial resistant bacteria and resistance genes from feces. The LPM is an important interface between humans, farm animals, and environments in a typical urban environment, and it is considered a reservoir for ARGs and viruses. However, the antibiotic resistomes shared between chicken farms and LPMs, and that of LPM workers and people who have no contact with the LPMs remains unknown. Methods We characterized the resistome and bacterial microbiome of farm chickens and LPMs and LPM workers and control subjects. The mobile ARGs identified in chickens and the distribution of the mcr-family genes in publicly bacterial genomes and chicken gut metagenomes was analyzed, respectively. In addition, the prevalence of mcr-1 in LPMs following the ban on colistin-positive additives in China was explored. Results By profiling the microbiomes and resistomes in chicken farms, LPMs, LPM workers, and LPM environments, we found that the bacterial community composition and resistomes were significantly different between the farms and the LPMs, and the LPM samples possessed more diversified ARGs (59 types) than the farms. Some mobile ARGs, such as mcr-1 and tet(X3), identified in chicken farms, LPMs, LPM workers, and LPM environments were also harbored by human clinical pathogens. Moreover, we found that the resistomes were significantly different between the LPM workers and those who have no contact with the LPMs, and more diversified ARGs (188 types) were observed in the LPM workers. It is also worth noting that mcr-10 was identified in both human (5.2%, 96/1,859) and chicken (1.5%, 14/910) gut microbiomes. Although mcr-1 prevalence decreased significantly in the LPMs across the eight provinces in China, from 190/333 (57.1%) samples in September 2016-March 2017 to 208/544 (38.2%) samples in August 2018-May 2019, it is widespread and continuous in the LPMs. Conclusion Live poultry trade has a significant effect on the diversity of ARGs in LPM workers, chickens, and environments in China, driven by human selection with the live poultry trade. Our findings highlight the live poultry trade as ARG disseminators into LPMs, which serve as an interface of LPM environments even LPM workers, and that could urge Government to have better control of LPMs in China. Further studies on the factors that promote antibiotic resistance exchange between LPM environments, human commensals, and pathogens, are warranted.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb42fd4f205066fdf006eb783d51513Test
https://pubmed.ncbi.nlm.nih.gov/33799229Test

المؤلفون: Tao Hu, Quanjiao Chen, Yifei Nie, Jianjun Chen, Yuhai Bi, George F. Gao, Changwen Ke, Juan Li, Yingxia Liu, Chuansong Quan, William J. Liu, Luzhao Feng, Weifeng Shi, Yun Xie, Qianli Wang, Wenjun Liu, Hongjie Yu, Gary Wong

المصدر: Transboundary and Emerging Diseases. 66:592-598

مصطلحات موضوعية: China, Lineage (genetic), Genotype, 040301 veterinary sciences, Reassortment, Biology, Poultry, 0403 veterinary science, 03 medical and health sciences, Animals, Longitudinal Studies, Clade, Phylogeny, Poultry Diseases, 030304 developmental biology, 0303 health sciences, Avian influenza virus, General Veterinary, General Immunology and Microbiology, Phylogenetic tree, Strain (biology), 04 agricultural and veterinary sciences, General Medicine, Virology, Ducks, Southern china, Influenza A virus, Influenza in Birds, Reassortant Viruses

الوصف: H6 subtype avian influenza virus (AIV) was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003(H6N2) (ST2853-like) (85.7%) and A/duck/Shantou/339/2000(H6N2) (ST339-like) (14.3%), in which ST2853-like strains predominate. These novel strains belonged to the H6N6 (n = 165, 84.2%), H6N2 (n = 30, 15.3%), and H6N3 (n = 1, 0.51%) subtypes, which could be classified into 36 genotypes including 12 novel genotypes described in this study. In particular, several strains possessed the V190 and S228 mutations in HA (H3 numbering), which is critical for human receptor binding and identical to the human-derived strain A/Taiwan/2/2013(H6N1). Furthermore, 10.3% of the H6N6 isolates possessed the N6-∆11b (59-69) deletion. In summary, we describe phylogenetic and molecular characterizations of H6 AIVs in southern China and highlight the constant prevalence of H6 AIVs in poultry as well as adaptation to mammalian hosts.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685d8aec7d5f19f10d21247ab0c56200Test
https://doi.org/10.1111/tbed.13037Test

المؤلفون: Zhe Liu, Yidong Fei, Yanyu Chen, Zhuang Ding, Renfu Yin, Junjiao Li, Xinxin Liu, Tobias Stoeger, Jianjun Chen, Yuhai Bi

المصدر: Transboundary Emer. Dis. 65, 1421-1428 (2018)
Transboundary and Emerging Diseases

مصطلحات موضوعية: 0301 basic medicine, Serotype, China, Genotype, Zoology, Animals, Wild, Biology, Serogroup, Aavv-6, Domestic Poultry, Intercontinental Transmission, Wild Bird, Feces, 03 medical and health sciences, Phylogenetics, Waterfowl, Animals, Avulavirus, Phylogeny, Poultry Diseases, General Veterinary, General Immunology and Microbiology, Phylogenetic tree, Bird Diseases, business.industry, Avulavirus Infections, Hemagglutination, intercontinental transmission, domestic poultry, Hemagglutination Tests, General Medicine, Poultry farming, biology.organism_classification, Ducks, 030104 developmental biology, wild bird, Rapid Communications, Animals, Domestic, Influenza in Birds, Cloaca, business, Chickens, Rapid Communication, AAvV‐6

الوصف: Up to now only nine whole genome sequences of avian avulavirus 6 (AAvV‐6) had been documented in the world since the first discovery of AAvV‐6 (AAvV‐6/duck/HongKong/18/199/77) at a domestic duck in 1977 from Hong Kong of China. Very limited information is known about the regularities of transmission, genetic and biological characteristics of AAvV‐6 because of the lower isolation rate and mild losses for poultry industry. To better further explore the relationships among above factors, an AAvV‐6 epidemiological surveillance of domestic poultry and wild birds in six provinces of China suspected of sites of inter‐species transmission and being intercontinental flyways during the year 2013–2017 was conducted. Therefore, 9,872 faecal samples from wild birds and 1,642 cloacal and tracheal swab samples from clinically healthy poultry of live bird market (LBM) were collected respectively. However, only one novel hemagglutination‐negative AAvV‐6 isolate (AAvV‐6/mallard/Hubei/2015) was isolated from a fresh faecal sample obtained from mallard at a wetland of Hubei province. Sequencing and phylogenetic analyses of this AAvV‐6 isolate (AAvV‐6/mallard/Hubei/2015) indicated that this isolate grouping to genotype I were epidemiological intercontinentally linked with viruses from the wild birds in Europe and America. Meanwhile, at least two genotypes (I and II) are existed within serotype AAvV‐6. In additional, this novel hemagglutination‐negative AAvV‐6 isolate in chicken embryos restored its hemagglutination when pre‐treated with trypsin. These findings, together with data from other AAvV‐6, suggest potential epidemiological intercontinental spreads among AAvV‐6 transmission by wild migratory birds, and reveal potential threats to wild birds and domestic poultry worldwide.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e696304817fe3a212efc91ca493c65Test
https://doi.org/10.1111/tbed.13005Test

المؤلفون: Jun Liu, Shenghua Mao, Min Zhao, Dayan Wang, Yun Xie, Zewu Zhang, Peipei Liu, William J. Liu, Jie Zhang, Chuansong Quan, Hongjie Yu, Ting Huang, Luzhao Feng, Qianli Wang, Qigang Dai, Baorong Zhang, Yifei Nie, Weifeng Shi, Yuhai Bi, George F. Gao

المصدر: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 25, Iss 12, Pp 2215-2225 (2019)

مصطلحات موضوعية: Male, Epidemiology, animal diseases, lcsh:Medicine, avian influenza virus, medicine.disease_cause, Antibodies, Viral, seroepidemiologic study, Poultry, 0302 clinical medicine, Seroepidemiologic Studies, Influenza A virus, Public Health Surveillance, 030212 general & internal medicine, influenza A, Farmers, seroprevalence, virus diseases, Middle Aged, Titer, Infectious Diseases, Female, Antibody, seroepidemiology, influenza, Microbiology (medical), Adult, Risk, China, 030231 tropical medicine, Biology, Serogroup, poultry worker, History, 21st Century, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, respiratory infections, Occupational Exposure, Influenza, Human, medicine, Seroprevalence, Animals, Humans, lcsh:RC109-216, viruses, Avian Influenza A Viruses among Occupationally Exposed Populations, China, 2014–2016, Seroconversion, Hemagglutination assay, Research, lcsh:R, Hemagglutination Inhibition Tests, Virology, Influenza A virus subtype H5N1, zoonoses, Influenza in Birds, occupational health, biology.protein

الوصف: To determine the seroprevalence and seroconversion of avian influenza virus (AIV) antibodies in poultry workers, we conducted a seroepidemiologic study in 7 areas of China during December 2014–April 2016. We used viral isolation and reverse transcription PCR to detect AIVs in specimens from live poultry markets. We analyzed 2,124 serum samples obtained from 1,407 poultry workers by using hemagglutination inhibition and microneutralization assays. We noted seroprevalence of AIV antibodies for subtypes H9N2, H7N9, H6N1, H5N1-SC29, H5N6, H5N1-SH199, and H6N6. In serum from participants with longitudinal samples, we noted seroconversion, with >4-fold rise in titers, for H9N2, H7N9, H6N1, H5N1-SC29, H6N6, H5N6, and H5N1-SH199 subtypes. We found no evidence of H10N8 subtype. The distribution of AIV antibodies provided evidence of asymptomatic infection. We found that AIV antibody prevalence in live poultry markets correlated with increased risk for H7N9 and H9N2 infection among poultry workers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffca02a92bda1b06804ef42da9118c7Test
https://pubmed.ncbi.nlm.nih.gov/31742536Test

المؤلفون: Yingze Zhao, Lijun Zhou, Qiang Lv, Lei Yang, Chunrong Long, Tiyan Zhang, Liumei Shu, Qianli Wang, Peipei Liu, Jie Zhang, Ting Huang, Xiuwei Chen, Hao Song, Yuhai Bi, George F. Gao, Weifeng Shi, Chuansong Quan, William J. Liu, Xunbo Du, Cheng Zhang

المصدر: Science China Life Sciences. 61:1123-1126

مصطلحات موضوعية: 0301 basic medicine, China, 030102 biochemistry & molecular biology, Hemagglutinin Glycoproteins, Influenza Virus, Genome, Viral, Biology, medicine.disease_cause, Genome, Virology, Poultry, General Biochemistry, Genetics and Molecular Biology, Influenza A virus subtype H5N1, 03 medical and health sciences, 030104 developmental biology, Viral genetics, Influenza A virus, Influenza in Birds, medicine, Animals, General Agricultural and Biological Sciences, Poultry Diseases, General Environmental Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3668baed1202f3e728963911b9ba357aTest
https://doi.org/10.1007/s11427-018-9327-4Test