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1
المؤلفون: Tao Feng, Juan He, Zheng-Hui Li, Fa-Lei Zhang, Ji-Kai Liu, Jun-Jie Yu, Hui-Xiang Yang
المصدر: Phytochemistry Letters. 46:143-148
مصطلحات موضوعية: Circular dichroism, biology, Chemistry, Stereochemistry, Plant Science, Fungus, biology.organism_classification, Biochemistry, chemistry.chemical_compound, Diaporthe, Kiwi, Pseudomonas syringae, Enantiomer, Antibacterial activity, Agronomy and Crop Science, Derivative (chemistry), Biotechnology
الوصف: Three previously undescribed compounds including two ergosterols, diaporthins A and B (1 and 2), and a pyrrolidinone derivative, (±)-diaporthin C (3), together with three known compounds 4‒6, were isolated from cultures of kiwi-associated fungus Diaporthe phragmitis. The racemic 3 was further separated into pure enantiomers. Their structures with absolute configurations were elucidated by means of spectroscopic analysis, as well as single crystal X-ray diffraction analysis and electronic circular dichroism (ECD) calculations. Compounds 5 and 6 showed antibacterial activity against Pseudomonas syringae pv. actinidae with MIC values of 25 and 6.25 μg/mL, respectively.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::643f1d963d7341fbfce17b23b2cdce0fTest
https://doi.org/10.1016/j.phytol.2021.10.013Test -
2
المؤلفون: Shi-Wei Liu, Tao Feng, Ji-Kai Liu, Zheng-Hui Li, Xiao-Yi Fan, Jian-Hai Ding
المصدر: Journal of Asian Natural Products Research. 25:497-502
مصطلحات موضوعية: Pharmacology, Inonotus, biology, Chemistry, Stereochemistry, Dimer, Organic Chemistry, Pharmaceutical Science, General Medicine, Secondary metabolite, biology.organism_classification, Analytical Chemistry, chemistry.chemical_compound, Complementary and alternative medicine, Drug Discovery, medicine, Molecular Medicine, Two-dimensional nuclear magnetic resonance spectroscopy, Human cancer, medicine.drug
الوصف: (-)-5-Methylmellein (1) and its new dimer (2) were isolated from cultures of the basidiomycete Inonotus sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR. The structure of Compound 2 was determined by single-crystal X-ray crystallographic analysis. Compound 2 was tested for the cytotoxicities against five human cancer cell lines.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0c2ea5820d35d1f5a4a2fac1c4ed337eTest
https://doi.org/10.1080/10286020.2021.2004129Test -
3
المؤلفون: Ya-Hong Yao, Zheng-Hui Guan, Zhi-Hui Ren, Hui-Yi Yang, Ming Chen
المصدر: Journal of the American Chemical Society. 143:7298-7305
مصطلحات موضوعية: Markovnikov's rule, chemistry.chemical_element, Palladium hydride, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Aminolysis, chemistry, Aniline hydrochloride, Palladium, Quaternary carbon
الوصف: Hydroaminocarbonylation of alkenes is one of the most promising yet challenging methods for the synthesis of amides. Herein, we reported the development of a novel and effective Pd-catalyzed Markovnikov hydroaminocarbonylation of 1,1-disubstituted or 1,1,2-trisubstituted alkenes with aniline hydrochloride salts to afford amides bearing an α quaternary carbon. The reaction makes use of readily available starting materials, tolerates a wide range of functional groups, and provides a facile and straightforward approach to a diverse array of amides bearing an α quaternary carbon. Mechanistic investigations suggested that the reaction proceeded through a palladium hydride pathway. The hydropalladation and CO insertion are reversible, and the aminolysis is probably the rate-limiting step.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b82c8a125c47888db549c1c72f1bb23Test
https://doi.org/10.1021/jacs.1c03454Test -
4
المؤلفون: Meng Wang, Ji-Kai Liu, Da-Ke Zhao, Chao-Jun Pu, Juan He, Tao Feng, Zheng-Hui Li
المصدر: Journal of Natural Products. 83:2743-2748
مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Conjugated system, Ring (chemistry), 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Conocybe siliginea, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Ic50 values, Molecular Medicine, Moiety, Derivative (chemistry)
الوصف: Conosiligins A-D (1-4), four ring-rearranged sesquiterpenoids, were isolated from cultures of the basidiomycete Conocybe siliginea. Their structures and absolute configurations were determined by detailed spectroscopic analyses and equivalent circulating density (ECD) calculations. Compounds 1 and 2 possess a 5/8-fused ring system, while 3 has a 5/6-fused backbone conjugated with a γ-lactone. Compound 4 is a 5,6-seco tremulane derivative with the loss of a skeletal carbon, featuring a tetracyclic system involving a pyranone moiety. Compounds 3 and 4 inhibited Con A-induced T cell proliferation with IC50 values of 12.3 and 6.6 μM, respectively.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::741922eef03a60316377f7cded25ac5eTest
https://doi.org/10.1021/acs.jnatprod.0c00681Test -
5
المؤلفون: Ji-Kai Liu, Tao Feng, Zheng-Hui Li, Jiao-Xian Du, Quan Dai, Fa-Lei Zhang
المصدر: ACS Omega, Vol 5, Iss 34, Pp 21961-21967 (2020)
مصطلحات موضوعية: biology, Agrocybe, General Chemical Engineering, General Chemistry, biology.organism_classification, Illudin, Edible mushroom, Chemistry, chemistry.chemical_compound, Phytochemical, chemistry, Organic chemistry, Homology (chemistry), Enantiomer, Cytotoxicity, QD1-999, Protoilludane
الوصف: To comprehensively understand the chemical constituents of the edible mushroom Agrocybe salicacola and their biological functions, a phytochemical separation of the cultural broth of A. salicacola led to the isolation of four new illudane sesquiterpenoids, agrocybins H-K (1-4), along with 10 known analogues (5-14). Compounds 2-4 were racemates of which 2 and 3 were further separated into single enantiomers as 2a/2b and 3a/3b. All new structures with absolute configurations were elucidated on the basis of an extensive spectroscopic analysis and quantum chemistry calculations. Compound 1 possesses a new carbon skeleton that might be derived from the protoilludane backbone. Compounds 1, 5, 8, and 9 show a certain degree of cytotoxicity to five human cancer cell lines. Compound 1 shows a mild inhibitory effect on nitric oxide production with an IC50 value of 31.4 μM. It is concluded that A. salicacola is rich in illudin derivatives with potential bioactivity prospects, which would make A. salicacola a good material of medicine and food homology.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bbb6d4f3c0b9a0317186062dd1d340Test
https://doi.org/10.1021/acsomega.0c03314Test -
6
المؤلفون: Hui-Xiang Yang, Li-Tang Sun, Zheng-Hui Li, Ji-Kai Liu, Tao Feng, Guo-Kai Wang, Yao Chen
المصدر: Phytochemistry Letters. 37:29-32
مصطلحات موضوعية: biology, 010405 organic chemistry, Stereochemistry, Zopfiella, Plant Science, Endophytic fungus, biology.organism_classification, 01 natural sciences, Biochemistry, Pyrone, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Ic50 values, Agronomy and Crop Science, Human cancer, Derivative (chemistry), Biotechnology
الوصف: Three undescribed bisabolane sesquiterpenoids, zopfiellins A–C (1‒3), and one new α-pyrone derivative, zofiellone (4), have been isolated from cultures of the endophytic fungus Zopfiella sp. Compound 2 is a rare trinor-bisabolane sesquiterpenoid and 3 has an unusual aromatic core. Compounds 3 and 4 possess mild cytotoxicities against three human cancer cell lines with a range of IC50 values from 12.3–27.3 μM.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5b9315d5368d15c1395e13390de720c4Test
https://doi.org/10.1016/j.phytol.2020.03.008Test -
7
المؤلفون: Zheng-Hui Li, Kuan Zhao, He-Ping Chen, Kai-Yue Han, Ji-Kai Liu, Tao Feng, Gui-Guang Cheng, Zhen-Zhu Zhao, Lin Zhou
المصدر: Journal of Natural Products. 83:401-412
مصطلحات موضوعية: Pharmacology, Fomitopsis, biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Basidiomycota, Fungus, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Concanavalin A, Xylaria longipes, Drug Discovery, Ic50 values, biology.protein, Molecular Medicine, Diterpene, Cytotoxicity
الوصف: Eighteen new nor-isopimarane diterpenes, xylarinorditerpenes A-R (1-18), along with two previously reported compounds, 14α,16-epoxy-18-norisopimar-7-en-4α-ol (19) and the labdane-type diterpene agatadiol (20), were isolated from cultures of the fungicolous fungus Xylaria longipes HFG1018 isolated from the wood-rotting basidiomycete Fomitopsis betulinus. The structure elucidation and relative configuration assignments of 1-18 were accomplished by interpretation of spectroscopic data and through computational methods. The absolute configurations of 1, 4, and 16 were determined by single-crystal X-ray diffraction. Compounds 1-16 possess an 18- or 19-nor-isopimarane skeleton, and compounds 17 and 18 possess an 18,19-dinor-isopimarane skeleton. Compounds 2-5, 9, 14, 19, and 20 showed immunosuppressive activity but were devoid of cytotoxicity against the cell proliferation by concanavalin A-induced T lymphocytes and lipopolysaccharide-induced B lymphocytes, with IC50 values varying from 1.0 to 27.2 μM and from 16.1 to 51.8 μM, respectively.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fca1920d2b384b45d0476bf1d9eefa91Test
https://doi.org/10.1021/acs.jnatprod.9b00889Test -
8
المؤلفون: Jiang-Yuan Zhao, Hongbin Zhang, Zheng-Hui Li, Jian-Hai Ding, Ji-Kai Liu, Tao Feng
المصدر: Journal of Asian Natural Products Research. 22:941-946
مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Organic Chemistry, Pharmaceutical Science, General Medicine, Daedaleopsis tricolor, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Botany, Molecular Medicine, Hydroxymethyl
الوصف: Two new compounds, daedatrin K (1) and 2-hydroxy-1-(5-(hydroxymethyl)furan-2-yl)propan-1-one (2), were isolated from cultures of the basidiomycetes Daedaleopsis tricolor. The new structures were el...
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8ea906ae3dabf7978e8c4ddc6b4b41e7Test
https://doi.org/10.1080/10286020.2019.1668377Test -
9
المؤلفون: Rong Huang, Ji-Kai Liu, He-Ping Chen, Rui Ma, Tao Feng, Yue-Ling Peng, Hui-Xiang Yang, Qian Li, Zheng-Hui Li
المصدر: Phytochemistry Letters. 32:119-122
مصطلحات موضوعية: biology, 010405 organic chemistry, Stereochemistry, Chemistry, Alkaloid, Rigidoporus microporus, Plant Science, Fungus, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Fermentation, Indolizine, No production, Agronomy and Crop Science, Two-dimensional nuclear magnetic resonance spectroscopy, Biotechnology
الوصف: Two previously undescribed cadinane-type sesquiterpenoids, rigidoporones A and B (1 and 2), along with an undescribed racemic indolizine alkaloid, (±)-rigidoporine A (3), were isolated from the rice fermentation of the wood-decay fungus Rigidoporus microporus. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR and HRMS spectroscopic analysis. Compounds 1 and 3 were evaluated for their inhibitory activity on NO production in murine monocytic RAW264.7 macrophages (IC50 > 25 μM).
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9a3398d8f70625e047a094fb286f2128Test
https://doi.org/10.1016/j.phytol.2019.05.016Test -
10
المؤلفون: Shah Saud, Zheng-Hui Guan, Ata Ur Rehman, Fazli Wahid, Muhammad Adnan, Shah Faisal, Saud Alamri, Manzer H. Siddiqui, Amjad Ali, Ala Ud Din, Wajid Nasim, Shah Fahad, Muhammad Zahir Shah, Kashif Jan, Shamsher Ali, Hafiz Mohkum Hammad
المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)مصطلحات موضوعية: Antioxidant, Silver, DPPH, Physiology, medicine.medical_treatment, Science, Proteus vulgaris, Nanoparticle, Metal Nanoparticles, Bacterial growth, Silver nanoparticle, Antioxidants, Article, chemistry.chemical_compound, medicine, Humans, Nanotechnology, Plantago, Multidisciplinary, Aqueous solution, biology, Bacteria, Biological techniques, technology, industry, and agriculture, Phenolic acid, Bacterial Infections, biology.organism_classification, Anti-Bacterial Agents, Environmental sciences, chemistry, Medicine, Nuclear chemistry
الوصف: Silver nanoparticles (Ag. NPs) have shown a biological activity range, synthesized under different environment-friendly approaches. Ag. NPs were synthesized using aqueous crude extract (ACE) isolated from Plantago lanceolata. The ACE and Ag. NPs were characterized and assessed their biological and antioxidant activities. The existence of nanoparticles (NPs) was confirmed by color shift, atomic force microscopy (AFM), and UV–Vis’s spectroscopy. The FT-IR analysis indicated the association of biomolecules (phenolic acid and flavonoids) to reduce silver (Ag+) ions. The SEM study demonstrated a sphere-shaped and mean size in the range of 30 ± 4 nm. The EDX spectrum revealed that the Ag. NPs were composed of 54.87% Ag with 20 nm size as identified by SEM and TEM. AFM has ended up being exceptionally useful in deciding morphological elements and the distance across of Ag. NPs in the scope of 23–30 nm. The TEM image showed aggregations of NPs and physical interaction. Ag. NPs formation also confirmed by XPS, DRS and BET studies. Ag. NPs showed efficient activity as compared to ACE, and finally, the bacterial growth was impaired by biogenic NPs. The lethal dose (LD50) of Ag. NPs against Agrobacterium tumefaciens, Proteus vulgaris, Staphylococcus aureus, and Escherichia coli were 45.66%, 139.71%, 332.87%, and 45.54%, with IC50 (08.02 ± 0.68), (55.78 ± 1.01), (12.34 ± 1.35) and (11.68 ± 1.42) respectively, suppressing the growth as compared to ACE. The antioxidant capacity, i.e., 2,2-diphenyl-1-picrylhydrazyl (DPPH) of Ag. NPs were assayed. ACE and Ag. NPs achieved a peak antioxidant capacity of 62.43 ± 2.4 and 16.85 ± 0.4 μg mL−1, compared to standard (69.60 ± 1.1 at 100 μg mL−1) with IC50 (369.5 ± 13.42 and 159.5 ± 10.52 respectively). Finally, the Ag. NPs synthesized by P. lanceolata extract have an excellent source of bioactive natural products (NP). Outstanding antioxidant, antibacterial activities have been shown by NPs and can be used in various biological techniques in future research.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5c8e73a7278ba0a2bf95afc008c4deTest
https://pubmed.ncbi.nlm.nih.gov/34675270Test