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المؤلفون: Yukari Kyumoto-Nakamura, Kento Nishida, Soichiro Sonoda, Sara Murata, Shion Hama, Toshio Kukita, Takayoshi Yamaza, Haruyoshi Yamaza, Kazuaki Nonaka, Yosuke Tanaka, Norihisa Uehara
المصدر: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2018)مصطلحات موضوعية: Male, 0301 basic medicine, Small interfering RNA, Bone Regeneration, Cell, Medicine (miscellaneous), Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Osteogenesis, lcsh:QD415-436, Phosphorylation, lcsh:R5-920, biology, Chemistry, Cell Differentiation, Phosphoinositide 3 kinase (PI3K), Up-Regulation, Cell biology, medicine.anatomical_structure, Molecular Medicine, Stem cell, lcsh:Medicine (General), Signal Transduction, Scaffold-free spheroidal calcified construct, Stem cells from apical papilla (SCAP), Biochemistry, Genetics and Molecular Biology (miscellaneous), lcsh:Biochemistry, Young Adult, 03 medical and health sciences, Spheroids, Cellular, medicine, Animals, Humans, Mammalian target of rapamycin (mTOR), Dental Papilla, Protein kinase B, PI3K/AKT/mTOR pathway, Sirolimus, Phosphoinositide 3-kinase, Research, AKT, Multipotent Stem Cells, Regeneration (biology), Mesenchymal stem cell, Mesenchymal Stem Cells, 030206 dentistry, Cell Biology, Dentinogenesis, 030104 developmental biology, Dentin, biology.protein, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da87115e32aceab171d86993f9bb56bTest
https://doi.org/10.1186/s13287-018-1077-9Test -
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المؤلفون: Weiping Wang, Kangtao Ma, Yinan Liu, Chunyan Zhou, Qin Lu, Ping Chen, Yang Wang, Zhe Yang, Tao Li, Yuyao Tian, Zhuqing Jia
المصدر: Bioscience Reports
مصطلحات موضوعية: 0301 basic medicine, Biophysics, Notch signaling pathway, cardiomyocytes, Biology, Fibroblast growth factor, Biochemistry, Bone morphogenetic protein 2, Cell Line, 03 medical and health sciences, Mice, Animals, Myocytes, Cardiac, Molecular Biology, PI3K/AKT/mTOR pathway, Research Articles, Sirolimus, FGF10, rapamycin, mammalian target of rapamycin (mTOR), Wnt signaling pathway, Cell Differentiation, Mouse Embryonic Stem Cells, Cell Biology, embryonic stem cells, Ascorbic acid, Molecular biology, Embryonic stem cell, Antigens, Differentiation, Cell biology, 030104 developmental biology, Gene Expression Regulation, embryonic structures, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb5ac3d69fd5fc28f1d2291d0abf91aTest
https://pubmed.ncbi.nlm.nih.gov/28396518Test -
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المؤلفون: Laura Sancillo, Rosa Alba Rana, Francesca Masiello, Fabrizio Martelli, Giovanni Barosi, Maria Zingariello, Judith D. Goldberg, Xiaochun Li, Fiorella Ciaffoni, Margherita Massa, Anna Rita Migliaccio, Barbara Ghinassi, Emanuela D'Amore
المساهمون: Zingariello, M, Martelli, F, Ciaffoni, F, Masiello, F, Ghinassi, B, D'Amore, E, Massa, M, Barosi, G, Sancillo, L, Li, X, Goldberg, Jd, Rana, Ra, Franco Migliaccio, Anna Rita
المصدر: Blood. 121:3345-3363
مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, Hematopoiesis and Stem Cells, Blotting, Western, Immunology, Spleen, Biology, Real-Time Polymerase Chain Reaction, Primary myelofibrosis (PMF) is characterized by fibrosis, ineffective hematopoiesis in marrow, and hematopoiesis in extramedullary sites and is associated with abnormal megakaryocyte (MK) development and increased transforming growth factor (TGF)-β1 release. To clarify the role of TGF-β1 in the pathogenesis of this disease, the TGF-β1 signaling pathway of marrow and spleen of the Gata1(low) mouse model of myelofibrosis (MF) was profiled and the consequences of inhibition of TGF-β1 signaling on disease manifestations determined. The expression of 20 genes in marrow and 36 genes in spleen of Gata1(low) mice was altered. David-pathway analyses identified alterations of TGF-β1, Hedgehog, and p53 signaling in marrow and spleen and of mammalian target of rapamycin (mTOR) in spleen only and predicted that these alterations would induce consequences consistent with the Gata1(low) phenotype (increased apoptosis and G1 arrest both in marrow and spleen and increased osteoblast differentiation and reduced ubiquitin-mediated proteolysis in marrow only). Inhibition of TGF-β1 signaling normalized the expression of p53-related genes, restoring hematopoiesis and MK development and reducing fibrosis, neovascularization, and osteogenesis in marrow. It also normalized p53/mTOR/Hedgehog-related genes in spleen, reducing extramedullary hematopoiesis. These data identify altered expression signatures of TGF-β1 signaling that may be responsible for MF in Gata1(low) mice and may represent additional targets for therapeutic intervention in PMF, Biochemistry, Transforming Growth Factor beta1, Mice, Bone Marrow, Fibrosis, Biomarkers, Tumor, medicine, Animals, Humans, GATA1 Transcription Factor, RNA, Messenger, RNA, Small Interfering, Myelofibrosis, PI3K/AKT/mTOR pathway, Oligonucleotide Array Sequence Analysis, Ineffective Hematopoiesis, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, TOR Serine-Threonine Kinases, Cell Biology, Hematology, Middle Aged, Flow Cytometry, medicine.disease, Chemokine CXCL12, Extramedullary hematopoiesis, Disease Models, Animal, Haematopoiesis, medicine.anatomical_structure, Primary Myelofibrosis, Case-Control Studies, Cancer research, Cytokines, Bone marrow, Signal Transduction
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c708320f0f269d9717c1cd36e3eb8bcTest
https://doi.org/10.1182/blood-2012-06-439661Test -
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المؤلفون: Woo-Jeong Lee, Sharada Kolekar, Christina M. Buchanan, Peter R. Shepherd, Stephen M. F. Jamieson, Jack U. Flanagan, Jackie D. Kendall, William A. Denny, Ripudaman Singh, James M. J. Dickson, Bruce C. Baguley, Gordon W. Rewcastle
المصدر: Biochemical Journal
مصطلحات موضوعية: PTEN, phosphatase and tensin homologue deleted on chromosome 10, PKB, protein kinase B, medicine.medical_treatment, TGI, tumour growth inhibition, BID, twice daily dosing, p110α E545K mutation, mTOR, mammalian target of rapamycin, ERK, extracellular-signal-regulated kinase, Biochemistry, Mice, Tumor Cells, Cultured, medicine, Animals, Humans, Protein Isoforms, Tensin, PTEN, Tissue Distribution, Enzyme Inhibitors, pan-phosphoinositide 3kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235, phosphoinositide 3-kinase α (PI3Kα), Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Homeodomain Proteins, Mice, Knockout, Phosphoinositide 3-kinase, biology, QD, once daily dosing, Growth factor, PIK3CA, Neoplasms, Experimental, Cell Biology, phosphoinositide 4-kinase (PI4K), PIK3CA H1047R mutation, PI4K, phosphoinositide 4-kinase, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, P110δ, biology.protein, Signal transduction, Proto-Oncogene Proteins c-akt, PI3K, phosphoinositide 3-kinase, Research Article, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a7d1444366d807c36dc5923f61ac0Test
https://doi.org/10.1042/bj20110502Test -
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المؤلفون: Suhua Zhu, Qing-Ping Li, Xiaowei Wu, Hong-Yi Zhu, Liang Hu, Maojuan Hao
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 614
International Journal of Molecular Sciences, Vol 18, Iss 3, p 614 (2017)مصطلحات موضوعية: Male, 0301 basic medicine, Nitric Oxide Synthase Type I, AMP-Activated Protein Kinases, lcsh:Chemistry, Mice, Ischemic Postconditioning, lcsh:QH301-705.5, Spectroscopy, chemistry.chemical_classification, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), General Medicine, Mitochondria, Computer Science Applications, Cell biology, Reperfusion Injury, cardiovascular system, Signal Transduction, medicine.drug, autophagy, adenosine monophosphate-activated protein kinase (AMPK), medicine.medical_specialty, Article, Catalysis, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Internal medicine, medicine, Animals, Physical and Theoretical Chemistry, Protein kinase A, ischemic postconditioning (IPostC), ischemia/reperfusion, neuronal nitric oxide synthase (nNOS), Molecular Biology, PI3K/AKT/mTOR pathway, Reactive oxygen species, Myocardium, Organic Chemistry, Autophagy, AMPK, medicine.disease, Adenosine, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Apoptosis, Reperfusion injury
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b699fa81934a03619a9805f733e92b6dTest
https://doi.org/10.3390/ijms18030614Test