GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease
| العنوان: | GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease |
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| المؤلفون: | Martinez, CH, Freeman, CM, Nelson, JD, Murray, S, Wang, X, Budoff, MJ, Dransfield, MT, Hokanson, JE, Kazerooni, EA, Kinney, GL, Regan, EA, Wells, JM, Martinez, FJ, Han, MK, Curtis, JL, Investigators, C |
| المصدر: | Respiratory research, vol 18, iss 1 Martinez, CH; Freeman, CM; Nelson, JD; Murray, S; Wang, X; Budoff, MJ; et al.(2017). GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. RESPIRATORY RESEARCH, 18, 42. doi: 10.1186/s12931-017-0521-1. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1f24z25pTest |
| بيانات النشر: | eScholarship, University of California, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Adult, Chronic Obstructive, Michigan, Aging, Growth Differentiation Factor 15, Chronic Obstructive Pulmonary Disease, Clinical Sciences, Respiratory System, Comorbidity, Coronary Artery Disease, Cardiorespiratory Medicine and Haematology, Cardiovascular, Sensitivity and Specificity, Pulmonary Disease, Risk Factors, Clinical Research, Tobacco, Humans, Lung, Heart Disease - Coronary Heart Disease, Aged, COPDGene Investigators, Tobacco Smoke and Health, Cross, Incidence, Prevention, Reproducibility of Results, Middle Aged, Atherosclerosis, Sectional Studies, Causality, Cross-Sectional Studies, Heart Disease, Good Health and Well Being, Asymptomatic Diseases, Multivariate Analysis, Respiratory, Female, Biomarkers |
| الوصف: | BackgroundGrowth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations between GDF-15 and subclinical coronary atherosclerosis, assessed by coronary artery calcium (CAC) score, in COPD subjects free of clinical cardiovascular disease (CVD).MethodsCross-sectional analysis of COPD participants (GOLD stages 2-4) in the COPDGene cohort without CVD at enrollment, using baseline CAC (from non-EKG-gated chest computed tomography) and plasma GDF-15 (by custom ELISA). We used multinomial logistic modeling of GDF-15 associations with CAC, adjusting for demographics, baseline risk (calculated using the HEART: Personal Heart Early Assessment Risk Tool (Budoff et al. 114:1761-1791, 2006) score), smoking history, measures of airflow obstruction, emphysema and airway disease severity.ResultsAmong 694 participants with COPD (47% women, mean age 63.6years) mean GDF-15 was 1,304pg/mL, and mean CAC score was 198. Relative to the lower GDF-15 tertile, higher tertiles showed bivariate association with increasing CAC score (mid tertile odds ratio [OR] 1.80, 95% confidence interval [CI] 1.29, 2.51; higher tertile OR 2.86, CI 2.04, 4.02). This association was maintained after additionally adjusting for baseline CVD risk, for co-morbidities and descriptors of COPD severity and impact, markers of cardiac stress (N-terminal pro-B-type natriuretic peptide, troponin T) and of inflammation (Interleukin-6), and in subgroup analysis excluding men, diabetics, current smokers or those with limited ambulation.ConclusionsIn ever-smokers with COPD free of clinical CVD, GDF-15 contributes independently to subclinical coronary atherosclerosis.Trial registrationClinicalTrials.gov, NCT00608764 . Registered 28 January 2008. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e692e538427ef3c70794f67b7b23ce6eTest https://escholarship.org/uc/item/1f24z25pTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..e692e538427ef3c70794f67b7b23ce6e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |