نتائج البحث - "Yousef Al-Abed"

1

Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation

المؤلفون: Sangeeta S. Chavan, Kevin J. Tracey, Kai Fan Cheng, Yousef Al-Abed, Qiong Zeng, Ulf Andersson, Hui Liu, Meghan E. Addorisio, Helena Erlandsson Harris, Mingzhu He, Jianhua Li, Huan Yang, Gavin H Imperato

المصدر: Molecular Medicine, Vol 25, Iss 1, Pp 1-13 (2019)
Molecular Medicine

مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, LPS, media_common.quotation_subject, Receptor for Advanced Glycation End Products, Enzyme-Linked Immunosorbent Assay, chemical and pharmacologic phenomena, Caspase-11, Cholinergic Agonists, Endocytosis, HMGB1, RAGE (receptor), Endocytosis sepsis, lcsh:Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Genetics, Animals, lcsh:QD415-436, HMGB1 Protein, Internalization, Cytokine, Molecular Biology, Cells, Cultured, Genetics (clinical), media_common, Inflammation, Mice, Inbred BALB C, biology, Chemistry, Macrophages, lcsh:RM1-950, Pyroptosis, Acetylcholine, RAGE, Cell biology, Nicotinic acetylcholine receptor, RAW 264.7 Cells, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Microscopy, Fluorescence, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Cholinergic, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5365f47cc4977a379d690b06763cba83Test
https://doi.org/10.1186/s10020-019-0081-6Test

2

Mechanistic insights into high mobility group box-1 (HMGb1)-induced Toll-like receptor 4 (TLR4) dimer formation

المؤلفون: Sonya VanPatten, Mingzhu He, Yousef Al-Abed, Shan Sun

المصدر: Journal of biomolecular structuredynamics. 37(14)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec4e4c78cedcf540ab97553680d741cTest
https://pubmed.ncbi.nlm.nih.gov/30238832Test

3

Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

المؤلفون: Tom R. Coleman, Kevin J. Tracey, Marco Bianchi, Yousef Al-Abed, Mingzhu He

المساهمون: He, Mingzhu, Bianchi, Marco E, Coleman, Tom R, Tracey, Kevin J, Al-Abed, Yousef

المصدر: Molecular Medicine, Vol 24, Iss 1, Pp 1-9 (2018)
Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da1570a1c0cb9009c3bd849d7f34aeaTest
https://doi.org/10.1186/s10020-018-0023-8Test

4

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

المصدر: The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE

مصطلحات موضوعية: Lipopolysaccharides, Male, Models, Molecular, Chemokine, medicine.medical_treatment, Blotting, Western, Immunology, Lymphocyte Antigen 96, chemical and pharmacologic phenomena, Inflammation, Biology, HMGB1, Cell Line, Immune system, Cell Line, Tumor, medicine, Animals, Immunology and Allergy, Disulfides, HMGB1 Protein, Cells, Cultured, Acetaminophen, Mice, Knockout, Innate immune system, Macrophages, Brief Definitive Report, R1, Survival Analysis, Protein Structure, Tertiary, 3. Good health, Cell biology, Mice, Inbred C57BL, Toll-Like Receptor 4, Cytokine, Biochemistry, Reperfusion Injury, TLR4, biology.protein, Cytokines, RNA Interference, Chemical and Drug Induced Liver Injury, medicine.symptom, Signal transduction, Peptides, Protein Binding, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3572863c34f6a481eabeb03ffcca319Test
https://doi.org/10.1084/jem.20141318Test

5

C1q and HMGB1 reciprocally regulate human macrophage polarization

المؤلفون: Amit Porat, Ulf Andersson, Bruce T. Volpe, Jolien Suurmond, Thomas Coleman, Betty Diamond, Yousef Al-Abed, Frances Santiago-Schwarz, Kevin J. Tracey, Myoungsun Son, Mingzhu He

المصدر: Blood. 128(18)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb43ff2c47a1248ac591ee9483a403eTest
https://pubmed.ncbi.nlm.nih.gov/27683415Test

6

Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes

المؤلفون: Yousef Al-Abed, Yongjun Wang, Shan Sun, Mingzhu He, Huan Yang

المصدر: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0193028 (2018)

مصطلحات موضوعية: B Vitamins, 0301 basic medicine, Damp, lcsh:Medicine, Pathology and Laboratory Medicine, Molecular Dynamics, Immune Receptors, Biochemistry, White Blood Cells, Database and Informatics Methods, Binding Analysis, Computational Chemistry, Biomimetic Materials, Animal Cells, Medicine and Health Sciences, Biochemical Simulations, HMGB1 Protein, Database Searching, Surface plasmon resonance, lcsh:Science, Toll-like Receptors, Immune Response, Immune System Proteins, Multidisciplinary, biology, Organic Compounds, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Vitamins, Cell biology, Molecular Docking Simulation, Physical Sciences, Tumor necrosis factor alpha, Cellular Types, medicine.symptom, Protein Binding, Signal Transduction, Research Article, Immune Cells, Immunology, Lymphocyte Antigen 96, chemical and pharmacologic phenomena, Inflammation, In Vitro Techniques, Molecular Dynamics Simulation, Research and Analysis Methods, HMGB1, 03 medical and health sciences, Folic Acid, Signs and Symptoms, Diagnostic Medicine, medicine, Humans, Chemical Characterization, Blood Cells, Tumor Necrosis Factor-alpha, Macrophages, lcsh:R, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Computational Biology, Cell Biology, Toll-Like Receptor 4, 030104 developmental biology, High-mobility group, Docking (molecular), biology.protein, TLR4, lcsh:Q, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd10de22c6a25b67cfb11458d8b41f4Test
https://doi.org/10.1371/journal.pone.0193028Test

7

Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis

المؤلفون: Maowen Hu, Xinchun Lin, Edmund J. Miller, Shinichiro Hayashi, Tohru Sakuragi, Huan Yang, Luis Ulloa, Lin L. Mantell, Yousef Al-Abed, Kevin J. Tracey

المصدر: American journal of physiology. Lung cellular and molecular physiology. 289(4)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fbd9aae9eb87f88340e3a7d6a44181Test
https://pubmed.ncbi.nlm.nih.gov/15937067Test

8

Identification of Pharmacological Modulators of HMGB1-Induced Inflammatory Response by Cell-Based Screening

المؤلفون: Petra Szoleczky, Yousef Al-Abed, Timothy R. Billiar, Csaba Szabó, Sangeeta Chevan, John P. Pribis, Huan Yang, Katalin Módis, Domokos Gero, Kevin J. Tracey

المصدر: PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e65994 (2013)

مصطلحات موضوعية: MAPK/ERK pathway, Critical Care and Emergency Medicine, Anti-Inflammatory Agents, Drug Evaluation, Preclinical, lcsh:Medicine, Gene Expression, Arthritis, Signal transduction, ERK signaling cascade, Pharmacology, Biochemistry, Dexamethasone, Mice, Catecholamines, Molecular cell biology, 0302 clinical medicine, Drug Discovery, HMGB1 Protein, Phosphorylation, lcsh:Science, 0303 health sciences, Multidisciplinary, Signaling cascades, Drug Synergism, Adrenergic beta-Agonists, 3. Good health, 030220 oncology & carcinogenesis, Medicine, Tumor necrosis factor alpha, Inflammation Mediators, medicine.symptom, Intracellular, Research Article, Biotechnology, Drugs and Devices, Drug Research and Development, Cell Survival, MAP Kinase Signaling System, Prednisolone, Immunology, Down-Regulation, chemical and pharmacologic phenomena, Inflammation, Biology, HMGB1, Microbiology, Cell Line, 03 medical and health sciences, Downregulation and upregulation, In vivo, Sepsis, medicine, Animals, Albuterol, Glucocorticoids, 030304 developmental biology, Tumor Necrosis Factor-alpha, Macrophages, lcsh:R, Immunity, medicine.disease, biology.protein, lcsh:Q, Energy Metabolism, Protein Processing, Post-Translational

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db140e4df2715398a84a23b1c7f4d2ebTest
https://doi.org/10.1371/journal.pone.0065994Test

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