التفاصيل البيبلوغرافية
العنوان:
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
المؤلفون:
Tricoci, P , Huang, Z , Held, C , Moliterno, Dj , Armstrong, Pw , Van de Werf, F , White, Hd , Aylward, Pe , Wallentin, L , Chen, E , Lokhnygina, Y , Pei, J , Leonardi, S , Rorick, Tl , Kilian, Am , Jennings, Lh , Ambrosio, G , Bode, C , Cequier, A , Cornel, Jh , Diaz, R , Erkan, A , Huber, K , Hudson, Mp , Jiang, L , Jukema, Jw , Lewis, Bs , Lincoff, Am , Montalescot, G , Nicolau, Jc , Ogawa, H , Pfisterer, M , Prieto, Jc , Ruzyllo, W , Sinnaeve, Pr , Storey, Rf , Valgimigli, M , Whellan, Dj , Widimsky, P , Strony, J , Harrington, Ra , Mahaffey, Kw , Huo, Y , Lixin, J , Isaza, D , Grande, P , Laine, M , Wong, L , Ofner, P , Yamaguchi, T , Park, Sj , Nordrehaug, Je , Providencia, L , Cheem, Th , Dalby, A , Betriu, A , Chen, Mf , Verheugt, F , Frye, Rl , Hochman, J , Steg, Pg , Bailey, Kr , Easton, Jd , Lincoff, A , Underwood, Fd , Wrestler, J , Larson, D , Vandyne, B , Kilian, A , Harmelin-Kadouri, R , Layton, L , Lipka, L , Petrauskas, S , Qidwai, M , Sorochuck, C , Temple, T , Mason, D , Sydlowski, D , Gallagher, B , Villasin, A , Beernaert, A , Douglas, S , Garrett, J , Wiering, J , Adriaenssens, T , Ganame, J , Hulselmans, M , Katz, Jn , Kayaert, P , La Gerche, A , Onsea, K , Zalewski, J , Johnson, A , O'Briant, J , Smith, M , Akerblom, A , Armaganijan, L , Bertolami, A , Brennan, M , da Ponte Nacif SA , de Campos Gonzaga, C , Dequadros, A , Déry, Jp , Dev, S , Ducrocq, G , Eapen, Zp , Echenique, L , Eggers, K , Garcia, H , Guimaraes, Hp , Hagstrom, E , Hanet, C , James, S , Jonelid, B , Kolls, Bj , Leiria, T , Leite, R , Lombardi, C , Lopes, Rd , Malagutti, P , Mathews, R , Mehta, Rh , Melloni, C , Piccini, Jp , Rodriques Soares, P , Roe, Mt , Shah, Br , Stashenko, G , Szczech, La , Truffa, A , Varenhorst, C , Vranckx, P , Williams, J , Kilaru, R , White, Ja , Binkowitz, B , He, W , Ramos, Ms , Hasbani, E , Farras, Ha , Luz del Valle, L , Zapata, G , Centeno, Ep , Hominal, M , Beloscar, J , Panno, M , Berli, M , Carlevaro, O , Wasserman, T , Lembo, L , Diez, F , Bettinotti, M , Allall, O , Macin, S , Hii, C , Bett, N , Aroney, C , Roberts-Thomson, P , Arstall, M , Horowitz, J , Prasan, A , Farshid, A , Rankin, J , Duffy, S , Sinhal, A , Hendricks, R , Waites, J , Hill, A , French, J , Adams, M , Soward, A , Dick, R , Jepson, N , Nelson, G , Thompson, P , Neunteufl, T , Pachinger, O , Leisch, F , Siostrzonek, P , Roithinger, F , Pieske, B , Weber, H , Eber, B , Zenker, G , Sinnaeve, P , Roosen, J , Vervoort, G , Coussement, P , Striekwold, H , Boland, J , Van Dorpe, A , Dujardin, K , Mertens, D , Vanneste, L , Celen, H , Lesseliers, H , Vrolix, M , Leone, A , De Maeseneire, S , Hellemans, S , Silva, Fa , Franken, M , Moraes JB Jr , Mora, R , Michalaros, Y , Perin, M , Guimaraes, Ae , da Silva DG , Mattos, Ma , Alves AR Jr , Hernandes, Me , Golin, V , da Silva SA , Ardito, W , Dery, Jp , Mukherjee, A , Tanguay, Jf , Kornder, J , Lutchmedial, S , Degrace, M , Klinke, P , Constance, C , Nogareda, G , Wong, G , Macdonald, P , Senaratne, M , Rupka, D , Halperin, F , Ramanathan, K , Natarajan, M , Lai, C , Brossoit, R , Tymchak, W , Rose, B , Dupuis, R , Mansour, S , Bata, I , Zadra, R , Turek, M , Madan, M , Le May, M , Leon, L , Perez, L , Yovaniniz, P , Pedemonte, O , Campos, P , Pincetti, C , Sepulveda, P , Li, W , Zhao, R , Li, Z , Yang, Y , Chen, J , Li, H , Jiang, Y , Li, D , Qu, P , Sun, Y , Zheng, Y , Zhou, C , Zhang, F , Wei, M , Wang, D , Lemus, J , Fernandez, Rl , Jaramillo, C , Ochoa, J , Velez, S , Cano, N , Lutz, J , Botero, R , Jaramillo, M , Saaib, J , Sanchez, G , Hernandez, H , Mendoza, F , Rizcala, A , Urina, M , Polasek, R , Motovska, Z , Zemanek, D , Ostransky, J , Kettner, J , Spinar, J , Groch, L , Ramik, C , Stumar, J , Linhart, A , Pleva, L , Niedobova, E , Macha, J , Vojacek, J , Stipal, R , Galatius, S , Eggert, S , Mickley, H , Egstrup, K , Pedersen, O , Hvilsted, L , Sykulski, R , Skagen, K , Dodt, K , Klarlund, K , Husted, S , Jensen, G , Melchior, T , Sjoel, A , Steffensen, Fh , Airaksinen, Ke , Laukkanen, Ja , Syvanne, Ms , Kotila, Mj , Mikael, K , Naveri, Hk , Hekkala, Am , Mustonen, Jn , Halkosaari, M , Ohlmann, P , Khalife, K , Dibon, O , Hirsch, Jl , Furber, A , Nguyen-Khac, Jo , Delarche, N , Probst, V , Lim, P , Bayet, G , Dauphin, R , Levai, L , Galinier, M , Belhassane, A , Wiedemann, Jy , Fouche, R , Coisne, D , Henry, P , Schiele, F , Boueri, Z , Vaquette, B , Davy, Jm , Cottin, Y , D'Houdain, F , Danchin, N , Cassat, C , Messner, P , Elbaz, M , Coste, P , Zemour, G , Maupas, E , Feldman, L , Soto, Fx , Ferrari, E , Haltern, G , Heuer, H , Genth-Zotz, S , Loges, C , Stellbrink, C , Terres, W , Ferrar, M , Zeymer, U , Brachmann, J , Mudra, H , Vohringer, Hf , vom Dah, J , Kreuzer, J , Hill, S , Kleinertz, K , Kadel, C , Appel, Kf , Nienabe, C , Behrens, S , Frantz, S , Mehrhof, F , Krings, P , Hengstenberg, C , Lueders, S , Hanefel, C , Krulls-Munch, J , Dorse, T , Leschke, M , Nogai, K , Butter, C , Darius, H , Fichtlscherer, Hp , Schmitt, C , Kasisk, Hp , Dorr, M , Fran, N , Jereczek, M , Wiemer, M , Nickenig, G , Boudriot, E , Werner, G , Altila, T , Strasser, R , Baldus, S , Desaga, M , Buerke, M , Land, S , Schunkert, H , Schulze, Ho , Holmer, S , Sohn, Hy , Burkhardt, W , Lauer, B , Schwimmbeck, P , Schoeller, R , Lapp, H , Gross, M , Kindermann, I , Schuster, P , Yu, Cm , Lee, S , Merkely, B , Apro, D , Lupkovics, G , Edes, I , Ungi, I , Piroth, Z , Csapo, K , Dezsi, Ca , Herczeg, B , Sereg, M , Butnaru, A , Lewis, B , Rosenschein, U , Mosseri, M , Turgeman, Y , Pollak, A , Shotan, A , Hammerman, H , Rozenman, Y , Gottlieb, S , Atar, S , Weiss, A , Marmor, A , Iakobishvili, Z , Mascia, F , De Cesare, N , Piovaccari, G , Ceravolo, R , Fiscella, A , Salvioni, A , Silvestri, O , Moretti, L , Severi, S , Carmina, Mg , De Caterina, R , Fattore, L , Terrosu, P , Trimarco, B , Ardissino, D , Uguccioni, L , Auguadro, C , Gregorio, G , De Ferrari, G , Testa, R , Evola, R , De Servi, S , Sganzerla, P , Vassanelli, C , Brunelli, C , Scherillo, M , Tamburino, C , Limido, A , Luzza, F , Percoco, Gf , Sinagra, G , Volpe, M , Crea, F , Fedele, F , Rasetti, G , Cinelli, F , Merlini, P , Sisto, F , Biancoli, S , Fresco, C , Corrada, E , Casolo, G , Santini, M , D'Alessandro, B , Antoniucci, D , Tuccillo, B , Assennato, P , Puccioni, E , Pasquetto, G , Perna, Gp , Morgagni, G , Takizawa, K , Kato, K , Oshima, S , Yagi, M , Asai, T , Kamiya, H , Hirokami, M , Sakota, S , Sueyoshi, A , Shimomura, H , Hashimoto, T , Miyahara, M , Matsumura, T , Nakao, K , Kakuta, T , Nakamura, S , Nishi, Y , Kawajiri, K , Nagai, Y , Takahashi, A , Ikari, Y , Hara, K , Koga, T , Fujii, K , Tobaru, T , Tsunoda, R , Uchiyama, T , Hirayama, H , Fujimoto, K , Sakurai, S , Tanigawa, T , Ohno, M , Yamamoto, E , Ikuta, S , Kato, A , Kikuta, K , Takami, A , Chong, Wp , Ong, Tk , Yusof, A , Maskon, O , Kahar, A , Breedveld, Rw , Bendermacher, Pe , Hamer, Bj , Oude Ophuis AJ , Nierop, Pr , Westendorp, Ic , Beijerbacht, Hp , Herrman, Jp , van 't Hof AW , Troquay, Rp , van der Meer, P , Peters, Rh , van Rossum, P , Liem, A , Pieterse, Mg , van Eck JW , van der Zwaan, C , Pasupati, S , Elliott, J , Tisch, J , Hart, H , Luke, R , Scott, D , Ternouth, I , White, H , Hamer, A , Harding, S , Wilkins, G , O'Meeghan, T , Harrison, N , Nilsen, D , Thalamus, J , Aaberge, L , Brunvand, H , Lutterbey, G , Omland, Tm , Eritsland, J , Wiseth, R , Aase, O , Campos, C , Horna, M , Toce, L , Salazar, M , Przewlocki, T , Ponikowski, P , Kasprzak, J , Kopaczewski, J , Musial, W , Mazurek, W , Kawecka-Jaszcz, K , Pluta, W , Dobrzycki, S , Loboz-Grudzien, K , Lewczuk, J , Karwowski, D , Grajek, S , Dudek, D , Trusz-Gluza, M , Kornacewicz-Jach, Z , Gil, R , Ferreira, J , Gavina, C , Ferreira, R , Martins, D , Garcia-Rinaldi, R , Ufret, R , Vazquez-Tanus, J , Banchs, H , Wong, A , Tan, Hc , Guerra, M , Ebrahim, I , Roux, J , Blomerus, P , Saaiman, A , Corbett, C , Pillay, T , Freeman, V , Horak, A , Zambakides, C , Burgess, L , Yoon, Jh , Ahn, Th , Gwon, Hc , Seong, Iw , Kim, Hs , Jeong, Mh , Kim, Yd , Chae, Sc , Hernandez, Jm , Pique, M , Fernandez Portales, J , Paz, Ma , Lopez Palop, R , Iniguez, A , Diaz Fernandez, J , Alvarez, P , Sanz, E , Heras, M , Sala, J , Goicolea, J , Cruz Fernandez, J , Serra, A , Fernandez Ortiz, A , Calle, G , Barriales, V , Albarran, A , Curos, A , Molano Casimiro FJ , Suarez, Ma , Franco, Sn , Bayon, J , Suarez, J , Belchi, J , Moreu, J , San Martin, M , Melgares Moreno, R , Aguirre Salcedo, J , Gonzalez Juanatey JR , Martinez Romero, P , Galache Osuna JG , Albertsson, P , Diderholm, E , Lycksell, M , Rasmanis, G , Swahn, E , Cherfan, P , Christensen, K , Lundman, P , Larson, Le , Vasko, P , Pripp, Cm , Johansson, A , Moccetti, T , Corti, R , Pieper, M , Mach, F , Eberli, F , Jeger, R , Rickli, H , Vogt, P , Windecker, S , Wu, Cj , Kao, Hl , Charng, Mj , Chang, Kc , Chen, Zc , Tsa, Cd , Shyu, Kg , Lai, Wt , Hsieh, Ic , Hou, Jy , Yeh, Hi , Ueng, Kc , Yin, Wh , Timurkaynak, T , Yigit, Z , Yilmaz, M , Boyaci, A , Sahin, M , Goktekin, O , Bozkurt, E , Ercan, E , Yildirir, A , Muthusamy, R , Keeling, P , Levy, T , Zaman, A , Cohen, A , Gorog, D , Baumbach, A , Oldroyd, K , Kadr, H , Tait, G , Bellenger, N , Davis, G , Shakespeare, C , Senior, R , Bruce, D , Uren, N , Trouton, T , Ahsan, A , Hamed, A , Malik, I , Sarma, J , Millar-Craig, M , Robson, H , Kennon, S , Sprigings, D , Brodie, B , Kang, Gs , Thomas, G , Cheng, Sc , Espinoza, A , Kassas, S , Jafar, Z , Kumar, P , Izzo, M , Wiseman, A , Chandna, H , Felten, W , D'Urso, M , Gudipati, Cr , Coram, R , Gill, S , Bengtson, J , Chang, M , Raisinghani, A , Blankenship, J , Harbor, Wf , Kraft, P , Ashraf, R , Chambers, J , Albirini, A , Malik, A , Ziada, K , Slepian, M , Taussig, A , Vernon, H , Jetty, P , Islam, Ma , Canaday, D , Martin, T , Burchenal, Jj , Gencheff, N , Nygaard, T , Panchal, V , Merritt, R , Abrahams, L , Lambert, C , Reyes, P , Leimbach, W , Chhabra, A , Caputo, R , Imburgia, M , Erickson, B , Kleiman, N , Hunter, J , Dehning, M , Graham, B , Strain, J , White, Jk , Mcgarvey, J Jr , Henderson, D , Treasure, C 2nd , Mirro, M , Pancholy, S , Helmy, T , Westerhausen, D , Dib, N , Penny, W , Kim, H , Degregorio, M , Jay, D , Kmonicek, J , Berlowitz, M , Starling, M , Langevin, E , Nelson, R , Singer, A , Siachos, A , Gibson, G , Parrott, C , Held, J , Puleo, P , Wolford, T , Omar, B , Brilakis, E , Lewis, S , Heller, L , Brener, S , Addo, T , Lieberman, S , Eisenberg, D , Feldman, R , Waksman, R , Waltman, J , Schulman, S , Bounds, C , Voyce, S , Batchelor, W , Dobies, D , Pasnoori, V , Chandrashekhar, Y , Vetrovec, G , Azrin, M , Spriggs, D , Hirsch, C , Smucker, M , Chetcuti, S , Stella, R , Levite, H , Shoukfeh, M , Vidovich, M , Saucedo, J , Fintel, D , Low, R , Gellman, J , Ahsan, C , Unks, Dm , Tolleson, T , Ceccoli, H , Aggarwal, K , Bhaktaram, V , Olson, C , Decaro, M , Kaluski, E , Mehta, V , Puma, J , Singh, V , Fulmer, J , Lewis, D , Khadra, S , Staniloae, C , East, M , Sundram, Ps , Anderson, J , Wasserman, H , Guy, D , Brill, D , Kruse, K , Ebrahimi, R , Nguyen, T , Keating, F , Srivastava, R , Wassmer, P , Todd, J 3rd , Stein, M , Hamzeh, I , Laxson, D , Hodson, R , Puri, S , Vijayaraghavan, K , Gazmuri, R , Chu, A , Vijay, N , Rabinowitz, A , Block, T , Agarwal, H , Martin, J , Zetterlund, P , Fortuin, D , Macdonell, A 3rd , Zouzoulas, S , Chepuri, V , Schmalfuss, C , Karve, M , Aviles, R , Lieberman, E , Amlani, M , Murphy, S , Shapiro, T , Herzog, E , Ariani, K , Bhagwat, R , Hockstad, E , Kai, W , Saririan, M , Roth, R , Weiland, F , Atassi, K , Harjai, K , Muhlestein, J , Marsh, R , Shokooh, S , Nahhas, A , Labroo, A , Mayor, M , Koshy, S , Tariq, M , Rayos, G , Jones, S , Klugherz, B , Dewey, R , Rashid, Hu , Wohns, D , Feiring, A , Bowles, M , Rohrbeck, S , Monroe, Vs , De Gottlieb, A , Gumm, D , Brown, C 3rd , Chang, D , Kalaria, V , Minisi, A , Joumaa, M , Josephson, R , Kleczka, J , Silver, K , Coleman, P , Brachfeld, C , Saltiel, F , Reiner, J , Carell, E , Hanovich, G , Rosenberg, M , Das, G , Blick, D
المساهمون:
Universitat de Barcelona
المصدر:
The New England Journal of Medicine, 366, 20-33https://doi.org/10.1056/NEJMoa1109719Test
سنة النشر:
2012
مصطلحات موضوعية:
Male , Pyridines , medicine.medical_treatment , Kaplan-Meier Estimate , law.invention , Lactones , Randomized controlled trial , law , Thrombin receptor antagonist , clopidogrel , placebo , thienopyridine derivative , vorapaxar , antithrombocytic agent , lactone , proteinase activated receptor 1 , pyridine derivative , Coronary Artery Bypass , Vorapaxar , Cardiovascular diseases [NCEBP 14] , Drugs , General Medicine , Middle Aged , Combined Modality Therapy , Cardiovascular diseases , Cardiovascular Diseases , Cardiology , Platelet aggregation inhibitor , Drug Therapy, Combination , Female , Plaquetes sanguínies , Intracranial Hemorrhages , Major bleeding , Medicaments , medicine.drug , medicine.medical_specialty , Acute coronary syndrome , Bypass cardiopulmonary , Hemorrhage , Pharmacotherapy , Blood platelets , Double-Blind Method , Angioplasty , Internal medicine , medicine , Humans , Receptor, PAR-1 , Acute Coronary Syndrome , Aged , business.industry , Malalties cardiovasculars , medicine.disease , Surgery , Bypass cardiopulmonar , business , Platelet Aggregation Inhibitors , Follow-Up Studies
الوصف:
Item does not contain fulltext BACKGROUND: Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS: In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, stroke, recurrent ischemia with rehospitalization, or urgent coronary revascularization. RESULTS: Follow-up in the trial was terminated early after a safety review. After a median follow-up of 502 days (interquartile range, 349 to 667), the primary end point occurred in 1031 of 6473 patients receiving vorapaxar versus 1102 of 6471 patients receiving placebo (Kaplan-Meier 2-year rate, 18.5% vs. 19.9%; hazard ratio, 0.92; 95% confidence interval [CI], 0.85 to 1.01; P=0.07). A composite of death from cardiovascular causes, myocardial infarction, or stroke occurred in 822 patients in the vorapaxar group versus 910 in the placebo group (14.7% and 16.4%, respectively; hazard ratio, 0.89; 95% CI, 0.81 to 0.98; P=0.02). Rates of moderate and severe bleeding were 7.2% in the vorapaxar group and 5.2% in the placebo group (hazard ratio, 1.35; 95% CI, 1.16 to 1.58; P
وصف الملف:
application/pdf
تدمد:
0028-4793
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17fda93f7cac2f60d461db93efc9917Test http://hdl.handle.net/2066/109982Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....a17fda93f7cac2f60d461db93efc9917
قاعدة البيانات:
OpenAIRE
