Glucagon-Like Peptide-2 Improves Both Acute and Late Experimental Radiation Enteritis in the Rat
| العنوان: | Glucagon-Like Peptide-2 Improves Both Acute and Late Experimental Radiation Enteritis in the Rat |
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| المؤلفون: | Ian Ahnfelt-Rønne, Ulfe Bang Olsen, Jean Bourhis, Marc Benderitter, Fabien Milliat, Marie-Catherine Vozenin-Brotons, Agnès François, Lars Thim, Sandra Torres |
| المساهمون: | Radiobiologie et épidémiologie (DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Novo Nordisk A/S |
| المصدر: | International Journal of Radiation Oncology Biology Physics International Journal of Radiation Oncology Biology Physics, 2007, 69 (5), pp.1563-1571. ⟨10.1016/j.ijrobp.2007.08.051⟩ |
| بيانات النشر: | Elsevier BV, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, Mucosal disruption, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Drug Evaluation, Preclinical, Wistar, radiation exposure, wound healing, animal cell, Small, 0302 clinical medicine, Intestinal mucosa, intestine injury, Fibrosis, Intestine, Small, Glucagon-Like Peptide 2, Radiation Enteritis, pelvis cancer, rat, Intestinal Mucosa, intestine villus, risk reduction, 0303 health sciences, Radiation, article, single drug dose, Glucagon-like peptide-2, Preclinical, Enteritis, Microscopic examination, X ray, Intestine, 3. Good health, Radiation Injuries, Experimental, radiation enteropathy, Mucosal ulceration, priority journal, Oncology, 030220 oncology & carcinogenesis, Acute Disease, intestine mucosa, proteinase, radiation injury, medicine.medical_specialty, intestine ulcer, animal experiment, Radiation enteropathy, intestine crypt, animal tissue, Experimental, 03 medical and health sciences, medicine, Animals, controlled study, Radiology, Nuclear Medicine and imaging, Rats, Wistar, Radiation Injuries, 030304 developmental biology, nonhuman, Radiotherapy, business.industry, animal model, intestine wall, Therapeutic effect, treatment response, medicine.disease, Rats, Radiation therapy, Consequential late effects, smooth muscle fiber, Chronic Disease, Drug Evaluation, Irradiation, Chronic radiation enteritis, Peptides, Wound healing, business, glucagon like peptide 2 |
| الوصف: | Purpose: Acute and/or chronic radiation enteritis can develop after radiotherapy for pelvic cancers. Experimental and clinical observations have provided evidence of a role played by acute mucosal disruption in the appearance of late effects. The therapeutic potential of acute administration of glucagon-like peptide-2 (GLP-2) against acute and chronic intestinal injury was investigated in this study. Methods and Materials: Intestinal segments were surgically exteriorized and exposed to 16.7 or 19 Gy X-rays. The rats were treated once daily with vehicle or a protease-resistant GLP-2 derivative for 14 days before irradiation, with or without 7 days of GLP-2 after treatment. Macroscopic and microscopic observations were made 2 and 15 weeks after radiation exposure. Results: In the control animals, GLP-2 induced an increase in intestinal mucosal mass, along with an increase in villus height and crypt depth. GLP-2 administration before and after irradiation completely prevented the acute radiation-induced mucosal ulcerations observed after exposure to 16.7 Gy. GLP-2 treatment strikingly reduced the late radiation damage observed after 19 Gy irradiation. Microscopic observations revealed an improved organization of the intestinal wall and an efficient wound healing process, especially in the smooth muscle layers. Conclusion: GLP-2 has a clear therapeutic potential against both acute and chronic radiation enteritis. This therapeutic effect is mediated through an increased mucosal mass before tissue injury and the stimulation of still unknown mechanisms of tissue response to radiation damage. Although these preliminary results still need to be confirmed, GLP-2 might be a way to limit patient discomfort during radiotherapy and reduce the risk of consequential late effects. © 2007 Elsevier Inc. All rights reserved. |
| تدمد: | 0360-3016 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e59e64ae76e1fbe18bf524f9be9c5cdTest https://doi.org/10.1016/j.ijrobp.2007.08.051Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9e59e64ae76e1fbe18bf524f9be9c5cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03603016 |
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