Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women
| العنوان: | Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women |
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| المؤلفون: | Vesentini, Giovana [UNESP], Barbosa, Angélica M.P. [UNESP], Damasceno, Débora C. [UNESP], Marini, Gabriela [UNESP], Piculo, Fernanda [UNESP], Matheus, Selma M.M. [UNESP], Hallur, Raghavendra L.S. [UNESP], Nunes, Sthefanie K. [UNESP], Catinelli, Bruna B. [UNESP], Magalhães, Claudia G. [UNESP], Costa, Roberto [UNESP], Abbade, Joelcio F. [UNESP], Corrente, José E. [UNESP], Calderon, Iracema M.P. [UNESP], Rudge, Marilza V.C. [UNESP], Souza, F. P. [UNESP], Hijas, A., Sobrevia, L., Palma, M. S. [UNESP], Graeff, C. F.O. [UNESP], Arni, R. K. [UNESP], Herculano, R. D. [UNESP], Salvadori, D. F. [UNESP], Dal Pai Silva, M. [UNESP], Lima, S. A.M. [UNESP], Emanueli, C., Felisbino, S. [UNESP], Barbosa, W. [UNESP], Atallah, A., Girão, M. J.B., Di Bella, Z., Uchoa, S. M., Payão, S., Berghman, B., De Bie, R., Junginger, B., Alves, F. C.B. [UNESP], Rossignoli, P. S. [UNESP], Prudencio, C. B. [UNESP], Orlandi, M. I.G. [UNESP], Gonçalves, M. I. [UNESP], Sarmento, B. V. [UNESP], Pinheiro, F. A. [UNESP], Sartorão, C. I. [UNESP], Quiroz, S. B.C.V. [UNESP], Reyes, D. R.A. [UNESP], Enriquez, E. M.A. [UNESP], Oliveira, R. G. [UNESP], Floriano, J. F. [UNESP], Marcondes, J. P.C. [UNESP], Costa, S. M.B. [UNESP], Dangió, T. D. [UNESP], Pascon, T. [UNESP], Melo, J. V.F. [UNESP], Takano, L. [UNESP], Reis, F. V.D.S. [UNESP], Caldeirão, T. D. [UNESP], Carr, A. M. [UNESP], Garcia, G. A. [UNESP], Rabadan, G. B. [UNESP], Bassin, H. C.M., Suyama, K. S. [UNESP], Damasceno, L. N. [UNESP], Takemoto, M. L.S. [UNESP], Menezes, M. D. [UNESP], Bussaneli, D. G. [UNESP], Nogueira, V. K.C. [UNESP], Lima, P. R. [UNESP], Lourenço, I. O. [UNESP], Marostica De Sá, J. [UNESP], Megid, R. A. [UNESP], Caruso, I. P. [UNESP], Rasmussen, L. T., Prata, G. M., Arantes, M. A. [UNESP], Ferraz, G. A.R. [UNESP], Camargo, L. P. [UNESP], Kron, M. R. [UNESP], Nunes, H. R.C. [UNESP] |
| المساهمون: | Universidade Estadual Paulista (Unesp), Universidade Sagrado Coração, Case Western Reserve University, Pontificia Universidad Catolica de Chile, Imperial College London, Universidade Federal de São Paulo (UNIFESP), Universidade Católica de Pernambuco, Faculdade de Medicina de Marília, Maastrich University, Charité Universitätsmedizin Berlin, Universidade do Sagrado Coração, Faculdades Integradas de Bauru |
| المصدر: | PLoS ONE Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP PLoS ONE, Vol 15, Iss 4, p e0231096 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Maternal Health, Rectus Abdominis, Biochemistry, 0302 clinical medicine, Endocrinology, Pregnancy, Animal Cells, Medicine and Health Sciences, Rectus abdominis muscle, Musculoskeletal System, Abdominal Muscles, Glucose tolerance test, 030219 obstetrics & reproductive medicine, Multidisciplinary, medicine.diagnostic_test, Muscles, Obstetrics and Gynecology, Animal Models, Gestational diabetes, Experimental Organism Systems, Immunohistochemistry, Medicine, Female, Anatomy, Cellular Types, medicine.drug, Research Article, Adult, medicine.medical_specialty, Endocrine Disorders, Science, 030209 endocrinology & metabolism, Research and Analysis Methods, Muscle Fibers, 03 medical and health sciences, Fetus, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Animals, Humans, Rats, Wistar, Gestational Diabetes, business.industry, Body Weight, Biology and Life Sciences, Proteins, Cell Biology, Glucose Tolerance Test, Skeletal Muscle Fibers, medicine.disease, Streptozotocin, Diabetes, Gestational, Disease Models, Animal, Skeletal Muscles, Metabolic Disorders, Animal Studies, Women's Health, business, Collagens |
| الوصف: | Made available in DSpace on 2020-12-12T02:01:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01 Associação Brasileira de Saúde Coletiva Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background and objective In the present study, we compared the effect of diabetic pregnancy on the rectus abdominis muscle (RAM) in humans and rats. We hypothesized that our animal model could provide valuable information about alterations in the RAM of women with Gestational Diabetes (GDM). Method Newborns female rats (n = 10/group) were administered streptozotocin (100 mg/kg body weight) subcutaneously and were mated on reaching adulthood, to develop the mild hyperglycemic pregnant (MHP) rat model. At the end of pregnancy, the mothers were sacrificed, and the RAM tissue was collected. Pregnant women without GDM (non-GDM group; n = 10) and those diagnosed with GDM (GDM group; n = 8) and undergoing treatment were recruited, and RAM samples were obtained at C-section. The RAM architecture and the distribution of the fast and slow fibers and collagen were studied by immunohistochemistry. Results No statistically significant differences in the maternal and fetal characters were observed between the groups in both rats and women. However, significant changes in RAM architecture were observed. Diabetes in pregnancy increased the abundance of slow fibers and decreased fast fiber number and area in both rats and women. A decrease in collagen distribution was observed in GDM women; however, a similar change was not observed in the MHP rats. Conclusion Our results indicated that pregnancy- associated diabetes- induced similar structural adaptations in the RAM of women and rats with slight alterations in fiber type number and area. These findings suggest that the MHP rat model can be used for studying the effects of pregnancy-associated diabetes on the fiber structure of RAM. Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ. Estadual Paulista-UNESP Department of Gynecology and Obstetrics São Paulo State University (UNESP) Botucatu Medical School Department of Physiotherapy and Occupational Therapy São Paulo State University (UNESP) School of Philosophy and Sciences Department of Health Sciences Universidade Sagrado Coração Department of Anatomy São Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics São Paulo State University (UNESP) Bioscience Institute Universidade Estadual Paulista Case Western Reserve University Pontificia Universidad Catolica de Chile Imperial College London Universidade Federal de São Paulo Universidade Católica de Pernambuco Faculdade de Medicina de Marília Maastrich University Charité Universitätsmedizin Berlin Universidade do Sagrado Coração Faculdades Integradas de Bauru Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ. Estadual Paulista-UNESP Department of Gynecology and Obstetrics São Paulo State University (UNESP) Botucatu Medical School Department of Physiotherapy and Occupational Therapy São Paulo State University (UNESP) School of Philosophy and Sciences Department of Anatomy São Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics São Paulo State University (UNESP) Bioscience Institute Universidade Estadual Paulista FAPESP: #2014/26852-6 FAPESP: #2016/01743-5 FAPESP: #2016/09710-9 |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a589bc04ca722e3f850e7ccfc4f1be1bTest https://pubmed.ncbi.nlm.nih.gov/32243473Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a589bc04ca722e3f850e7ccfc4f1be1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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