المؤلفون: Carly S. Mazzone, Antonio Dominguez-Meijide, Jeffrey L. Brodsky, Mary Liang, Tiago F. Outeiro, Annette N. Chiang, David Newhouse, Peter Wipf, Nathan M. Kendsersky, Megan E. Yates, Patrick G. Needham, Caterina Masaracchia, Alexandra Manos-Turvey, Jennifer L. Goeckeler-Fried

المصدر: Bioorganic & Medicinal Chemistry. 27:79-91

مصطلحات موضوعية: Protein Folding, Clinical Biochemistry, Mutant, Cystic Fibrosis Transmembrane Conductance Regulator, Enzyme Activators, Pharmaceutical Science, Pyrimidinones, Saccharomyces cerevisiae, Protein aggregation, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, Cell Line, Tumor, Cellular stress response, Drug Discovery, Humans, HSP70 Heat-Shock Proteins, Molecular Biology, Adenosine Triphosphatases, Molecular Structure, biology, 010405 organic chemistry, Activator (genetics), Chemistry, Organic Chemistry, HEK 293 cells, Esters, Cystic fibrosis transmembrane conductance regulator, 3. Good health, 0104 chemical sciences, Hsp70, Cell biology, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Proteostasis, alpha-Synuclein, biology.protein, Molecular Medicine, Protein Multimerization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5c63d4a71c5b638613d360a3ee103Test
https://doi.org/10.1016/j.bmc.2018.11.011Test

المؤلفون: Guowei Yin, Karin Giller, Markus Zweckstetter, Tiago F. Outeiro, Timo Strohäker, Francesca Munari, Joshua Salafsky, Ben Moree, Diana F. Lázaro, Stefan Becker

المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry
The journal of biological chemistry 290(46), 27582-27593 (2015). doi:10.1074/jbc.M114.636027

مصطلحات موضوعية: Protein Conformation, animal diseases, pharmacology [Small Molecule Libraries], Protein aggregation, Ligands, Biochemistry, Antiparkinson Agents, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, Neurons, 0303 health sciences, Tumor, Drug discovery, Parkinson Disease, Small molecule, 3. Good health, metabolism [Neurons], ddc:540, chemistry [Antiparkinson Agents], alpha-Synuclein, Parkinson disease, drug discovery, protein aggregation, protein conformation, protein drug interaction, Cell Line, Tumor, Humans, Protein Aggregates, Protein Aggregation, Pathological, Small Molecule Libraries, isolation & purification [Small Molecule Libraries], Molecular Biophysics, chemistry [Small Molecule Libraries], metabolism [Parkinson Disease], Cell Line, 03 medical and health sciences, metabolism [Protein Aggregation, Pathological], Pathological, mental disorders, Molecular Biology, 030304 developmental biology, Alpha-synuclein, pharmacology [Antiparkinson Agents], drug therapy [Protein Aggregation, Pathological], Binding protein, drug effects [Protein Aggregates], Cell Biology, Protein Aggregation, drug therapy [Parkinson Disease], isolation & purification [Antiparkinson Agents], nervous system diseases, drug effects [Protein Conformation], chemistry [alpha-Synuclein], nervous system, chemistry, Biophysics, 030217 neurology & neurosurgery, Protein ligand

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94d4e41f529440ed17d7b805a1a18abTest
https://doi.org/10.1074/jbc.m114.636027Test

المؤلفون: Patrícia Guerreiro, Susana Gonçalves, Salvador Ventura, Evangelia Emmanouilidou, Anna Villar-Piqué, Tiago Antônio de Oliveira Mendes, Flaviano Giorgini, Duarte C. Barral, Tiago F. Outeiro, Zrinka Marijanovic, Oldriska Chutna, Kostas Vekrellis, José S. Ramalho, Jochen Klucken

المصدر: Human Molecular Genetics. 23:6732-6745

مصطلحات موضوعية: Recombinant Fusion Proteins, Endocytic cycle, Biology, Protein aggregation, Exosomes, Transfection, Protein Aggregates, chemistry.chemical_compound, Cell Line, Tumor, Genetics, Humans, Small GTPase, Secretion, RNA, Small Interfering, Molecular Biology, Genetics (clinical), Inclusion Bodies, Neurons, Alpha-synuclein, Synucleinopathies, Biological Transport, General Medicine, 3. Good health, Cell biology, Gene Expression Regulation, chemistry, rab GTP-Binding Proteins, alpha-Synuclein, Signal transduction, Intracellular, Plasmids, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09d3fc061845d548e7717940d3d2750Test
https://doi.org/10.1093/hmg/ddu391Test

المؤلفون: Cristiana Faria, Nuno Borges, Tiago F. Outeiro, Sandra Tenreiro, Carla D. Jorge, Helena Santos

المصدر: Biochimica et Biophysica Acta (BBA) - General Subjects. 1830:4065-4072

مصطلحات موضوعية: Protein Folding, Saccharomyces cerevisiae, Biophysics, Protein aggregation, Biology, Glyceric Acids, Biochemistry, Green fluorescent protein, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fluorescence microscope, Humans, Molecular Biology, 030304 developmental biology, Alpha-synuclein, 0303 health sciences, Protein Stability, Parkinson Disease, biology.organism_classification, In vitro, 3. Good health, chemistry, alpha-Synuclein, Chemical chaperone, Reactive Oxygen Species, Mannose, 030217 neurology & neurosurgery, Intracellular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8c2c12c416f684a73b2a7117c3c774Test
https://doi.org/10.1016/j.bbagen.2013.04.015Test

المؤلفون: Raquel Pinho, Tomás Lopes da Fonseca, Tiago F. Outeiro

المصدر: Human molecular genetics. 25(14)

مصطلحات موضوعية: 0301 basic medicine, Cathepsin D, Endosomes, Biology, Protein aggregation, medicine.disease_cause, Endoplasmic Reticulum, Protein Aggregation, Pathological, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Genetics, medicine, Humans, Protein kinase A, Molecular Biology, Genetics (clinical), Alpha-synuclein, Mutation, Cell Death, Endoplasmic reticulum, Brain, Parkinson Disease, General Medicine, 3. Good health, Proton-Translocating ATPases, 030104 developmental biology, chemistry, Gene Expression Regulation, Cancer research, Unfolded protein response, alpha-Synuclein, Lysosomes, 030217 neurology & neurosurgery, Intracellular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99384c694f1edf2d42e5aa734323d477Test
https://pubmed.ncbi.nlm.nih.gov/27282395Test