نتائج البحث - "Brian S. J. Blagg"

1

The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

المؤلفون: Brian S. J. Blagg, Michael A. Serwetnyk

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1446-1468 (2021)

مصطلحات موضوعية: MD, middle domain, Review, SUMO, small ubiquitin-like modifier, TPR2A, tetratricopeptide-containing repeat 2A, chemistry.chemical_compound, 0302 clinical medicine, Immunophilins, polycyclic compounds, General Pharmacology, Toxicology and Pharmaceutics, Natural products, 0303 health sciences, biology, Small molecules, HIF-1α, hypoxia-inducing factor-1α, HSQC, heteronuclear single quantum coherence, Geldanamycin, Hsp90, CTD, C-terminal domain, Radicicol, Cell biology, 030220 oncology & carcinogenesis, HOP, Hsp70‒Hsp90 organizing protein, SAHA, suberoylanilide hydroxamic acid, Protein folding, ATP, adenosine triphosphate, Cdc37, cell division cycle 37, RM1-950, Protein–protein interaction, 03 medical and health sciences, TROSY, transverse relaxation-optimized spectroscopy, Heat shock protein, SAR, structure–activity relationship, NTD, N-terminal domain, Heat shock, 030304 developmental biology, Disruptors, TRAP1, Hsp75tumor necrosis factor receptor associated protein 1, Hsp90, 90-kD heat shock protein, Her-2, human epidermal growth factor receptor-2, Aha1, activator of Hsp90 ATPase homologue 1, HIP, Hsp70-interaction protein, hERG, human ether-à-go-go-related gene, PPI, protein−protein interaction, ADP, adenosine diphosphate, chemistry, Grp94, 94-kD glucose-regulated protein, biology.protein, Protein−protein interactions, Therapeutics. Pharmacology, Peptidomimetics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d551031a93c74226093f0f0844e22506Test
https://doi.org/10.1016Test/j.apsb.2020.11.015

2

A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro

المؤلفون: Brian S. J. Blagg, Mark S. Cohen, Derek Ge, Chitra Subramanian, Nina Zhang, Rebecca Gorney, Ton Wang, Ang Zuo

المصدر: Surgery

مصطلحات موضوعية: Aminocoumarins, Antineoplastic Agents, 030230 surgery, Heat Shock Protein Inhibitor, Article, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Western blot, Cell Line, Tumor, Heat shock protein, Adenocarcinoma, Follicular, medicine, Humans, Glycolysis, HSP90 Heat-Shock Proteins, Thyroid Neoplasms, medicine.diagnostic_test, business.industry, Phenylurea Compounds, Cell biology, Metabolic pathway, Real-time polymerase chain reaction, chemistry, Drug Resistance, Neoplasm, Thyroid Epithelial Cells, 030220 oncology & carcinogenesis, Quinolines, Surgery, Drug Screening Assays, Antitumor, Lenvatinib, business, Pyruvate kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d760782125c29dca019d237afaa2b438Test
https://doi.org/10.1016Test/j.surg.2020.06.009

3

Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models

المؤلفون: Austin Flohrschutz, Sanket J. Mishra, Brian S. J. Blagg, John M. Streicher, Tally M. Largent-Milnes, Wei Lei, Austen Thompson, Carrie Stine, Deziree L Coleman

المصدر: Pain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f66a3d1db9bfc8d408107fb33d81bd4Test
https://doi.org/10.1097Test/j.pain.0000000000001886

4

A novel heat shock protein 90 inhibitor potently targets adrenocortical carcinoma tumor suppression

المؤلفون: Mark S. Cohen, Chitra Subramanian, Brian S. J. Blagg, Ton Wang

المصدر: Surgery. 167:233-240

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e2e32010bf6ff7ba6116aaaba2a8c7Test
https://doi.org/10.1016Test/j.surg.2019.06.052

5

A novel C-terminal Hsp90 inhibitor KU758 synergizes efficacy in combination with BRAF or MEK inhibitors and targets drug-resistant pathways in BRAF-mutant melanomas

المؤلفون: Monica Chanda, Mark S. Cohen, Nina Zhang, Ton Wang, Brian S. J. Blagg, Chitra Subramanian, Barbara N. Timmermann, Jackee N Sanchez, Gary Shanguan

المصدر: Melanoma research. 31(3)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e506683c54633d53faa736e76c7df38Test
https://pubmed.ncbi.nlm.nih.gov/33904516Test

6

The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies

المؤلفون: Bradley M Keegan, Subhabrata Chaudhury, Brian S. J. Blagg

المصدر: Med Res Rev

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee18a9a3acd607a45e88a2fa0df2675fTest
https://pubmed.ncbi.nlm.nih.gov/32844464Test

7

Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway

المؤلفون: David I. Duron, Natalie K. Barker, Paul R. Langlais, Sanket J. Mishra, Brian S. J. Blagg, John M. Streicher, Carrie Stine, Wei Lei

المصدر: Sci Signal

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefa82d1ba022c18ed2409300f194004Test
https://doi.org/10.1126/scisignal.aaz1854Test

8

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

المؤلفون: Genesis M. Rivera-Marquez, Kristin Beebe, Jane B. Trepel, Joseph Jackson, Jason E. Gestwicki, Shuichi Ohkubo, Brian S. J. Blagg, Andy D. Tran, Leonard M. Neckers

المصدر: Journal of thrombosis and haemostasis : JTH, vol 18, iss 5
J Thromb Haemost

مصطلحات موضوعية: Blood Platelets, Platelet Aggregation, 1.1 Normal biological development and functioning, Clinical Sciences, Platelet Glycoprotein GPIIb-IIIa Complex, 030204 cardiovascular system & hematology, Cardiorespiratory Medicine and Haematology, Cardiovascular, Article, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Underpinning research, Heat shock protein, Humans, cancer, Platelet, Platelet activation, Heat-Shock Proteins, Hemostasis, biology, Chemistry, Hematology, Hsp90, Hsp70, Cell biology, Cardiovascular System & Hematology, Alpha Granule, heat shock proteins, platelets, biology.protein, antiplatelet agents, Platelet Aggregation Inhibitors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4128098ba7b7ea7a5479d73ddd19afcTest
https://escholarship.org/uc/item/9408m7xrTest

9

Molecular insights into the interaction of Hsp90 with allosteric inhibitors targeting the C-terminal domain

المؤلفون: Brian S. J. Blagg, Zheng Zhang, Ioannis Gelis, Edvinas Sipavicius, Rachel E. Davis, Radwan Ebna Noor, Vasantha Kumar Mv, Dimitra Keramisanou

المصدر: MedChemComm. 9:1323-1331

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcf024f772e66a14f5bb5802368a92Test
https://doi.org/10.1039/c8md00151kTest

10

Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells

المؤلفون: M.W. Sim, K.J. Kovatch, Mark E. Prince, Brian S. J. Blagg, Mark S. Cohen, Chitra Subramanian, R. Davis, Thomas E. Carey, Grace M. Wang

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 12, Pp 1003-1011 (2017)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Pathology, BMI1, B lymphoma Mo-MLV insertion region 1 homolog, EMT, epithelial to mesenchymal transition, Vimentin, HNSCC, head and neck squamous cell carcinoma, SCC, squamous cell carcinoma, Mice, 0302 clinical medicine, Tumor Cells, Cultured, Cell Self Renewal, HSP, heat shock protein (Hsp90, Hsp70), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Gene Expression Regulation, Neoplastic, WB, Western blot, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Neoplastic Stem Cells, Signal Transduction, Original article, medicine.medical_specialty, KU, Kansas University (compounds KU757, KU711), Cell Survival, Antineoplastic Agents, Biology, lcsh:RC254-282, 03 medical and health sciences, Cancer stem cell, Cell Line, Tumor, medicine, Animals, Humans, Protein Interaction Domains and Motifs, HSP90 Heat-Shock Proteins, Epithelial–mesenchymal transition, Squamous Cell Carcinoma of Head and Neck, Mesenchymal stem cell, CD44, medicine.disease, Xenograft Model Antitumor Assays, CSC, cancer stem cell, Head and neck squamous-cell carcinoma, Disease Models, Animal, MicroRNAs, ALDH, aldehyde dehydrogenase, 030104 developmental biology, Drug Resistance, Neoplasm, BMI1, Cell culture, Cancer research, biology.protein, UMSCC, University of Michigan Squamous Cell Carcinoma (cell lines UMSCC 22, UMSCC 22B-cis), Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c7acd843e614f5b59079b1412b9eeeTest
https://doi.org/10.1016Test/j.neo.2017.09.003

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