Platinum and Palladium Complexes Bearing New (1R,2R)-(-)-1,2-Diaminocyclohexane (DACH)-Based Nitrogen Ligands: Evaluation of the Complexes Against L1210 Leukemia
| العنوان: | Platinum and Palladium Complexes Bearing New (1R,2R)-(-)-1,2-Diaminocyclohexane (DACH)-Based Nitrogen Ligands: Evaluation of the Complexes Against L1210 Leukemia |
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| المؤلفون: | Yousef Al-Abed, Mika Kettunen, Markku Leskelä, Adnan S. Abu-Surrah |
| المصدر: | Zeitschrift für anorganische und allgemeine Chemie. 634:2655-2658 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Cisplatin, Denticity, 010405 organic chemistry, Ligand, Stereochemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Aldehyde, 3. Good health, 0104 chemical sciences, Inorganic Chemistry, chemistry, Yield (chemistry), medicine, Platinum, Diimine, Palladium, medicine.drug |
| الوصف: | The reaction of (1R,2R)-(–)-1,2-diaminocyclohexane (1) [DACH] with the aldehyde (1R)-(–)-myrtenal (2) in MeOH afforded the bidentate diimine ligand, (1R,2R)-(–)-N1,N2-bis{(1R)-(–)myrtenylidene}-1,2-diaminocyclohexane (3) in a high yield. Reduction of 3 using LiAlH4 led to the formation of the desired ligand (4) (1R,2R)-(–)-N1,N2-bis{(1R)-(–)myrtenyl}-1,2-diaminocyclohexane. Treatment of compound 4 with K2PtCl4 or K2PdCl4 yielded the corresponding platinum(II) and palladium(II) complexes, Pt-5 and Pd-6, respectively. The reaction of compound 3 with K2PtCl4 gave the diimine complex Pt-7. The cytotoxic activity of the complexes Pt-5, Pd-6 and Pt-7 was tested and compared to the approved drugs, cisplatin (Cis-Pt) and oxaliplatin (Ox-Pt). The complexes (Pt-5, Pd-6 and Pt-7) inhibit L1210 cell line proliferation with an IC50 of 0.6, 4.2, and 0.7 μL, respectively as evidenced by measuring thymidine incorporation. |
| تدمد: | 1521-3749 0044-2313 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f98a0db80a45fba1e554d3e8bedad4c6Test https://doi.org/10.1002/zaac.200800281Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........f98a0db80a45fba1e554d3e8bedad4c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213749 00442313 |
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