Assessment of immune responses to hepatitis A vaccination in children aged 1 and 2 years
| العنوان: | Assessment of immune responses to hepatitis A vaccination in children aged 1 and 2 years |
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| المؤلفون: | Ayşe Melda Sinirtaş, Mustafa Hacimustafaoğlu, Solmaz Celebi, Yücehan Albayrak |
| المساهمون: | Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/ Mikrobiyoloji Anabilim Dalı., Çelebi, Solmaz, Hacımustafaoğlu, Mustafa Kemal, Albayrak, Yücehan, Sinirtaş, Ayşe Melda |
| المصدر: | Volume: 43, Issue: 4 617-624 Turkish Journal of Medical Sciences |
| بيانات النشر: | The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Clinical assessment, Hepatitis A vaccine, Seroprevalence, Need, Maternal antibody, Infection prevention, Hepatitis A, Vaccination, Marginal Structural Models, Child, Drug safety, Children, Hepatitis antibody, Immunogenicity, Headache, Injection site pain, General Medicine, Child health care, Arthralgia, Normal human, Medicine, general & internal, Clinical trial, Human experiment, Seroconversion, Female, Safety, Infants, Human, medicine.medical_specialty, Hyperemia, Article, Treatment duration, Adverse outcome, Immune system, Antigen, Immunoglobulin M antibody, Gastrointestinal symptom, Internal medicine, Injection site induration, medicine, Immune response, Adverse effect, Key words: Hepatitis A vaccine,seroprevalence,safety,immunogenicity,children, business.industry, Injection site erythema, Abdominal discomfort, Systemic disease, Infant, Myalgia, Sex difference, Drug efficacy, Clinical effectiveness, Immunoglobulin G antibody, Preschool child, General & internal medicine, business, Controlled study |
| الوصف: | Aim: Hepatitis A can be prevented by vaccination. The aim of this study was to determine seropositivity for hepatitis A before vaccination in healthy children 12 and 24 months of age and compare seroconversion rates after vaccination between these 2 groups. Materials and methods: Forty-nine children aged 1 year (Group 1) and 51 children aged 2 years (Group 2) were included in the study. Inactive hepatitis A vaccine (Avaxim, 80 antigenic subtypes, 0.5 mL) were administered to every child in 2 doses, 6 months apart. Anti-hepatitis A virus (HAV) IgG and IgM antibodies were detected by Architect HAVAb-IgG and HAVAb-IgM (Abbott, Wiesbaden, Germany) test kits. Results: Nine percent of the children were seropositive for anti-HAV IgG before vaccination. The seroconversion rate at 2 weeks was 34% and 44% in Group 1 and Group 2, respectively. At 4 weeks the seroconversion rate was 87.7% and 90.1% in Group 1 and Group 2, respectively. All of the children who completed the vaccination program were seropositive at 28 weeks (after the second dose). No serious adverse reaction was observed in any of the children. Conclusion: It was determined that Avaxim, including 80 antigen units, is safe and immunogenic in healthy children 12 and 24 months of age. |
| وصف الملف: | application/pdf |
| تدمد: | 1303-6165 1300-0144 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cde8f09eae10130c27db0e47feb4001Test https://doi.org/10.3906/sag-1206-99Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9cde8f09eae10130c27db0e47feb4001 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13036165 13000144 |
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