Precise enhancement quantification in post-operative MRI as an indicator of residual tumor impact is associated with survival in patients with glioblastoma
| العنوان: | Precise enhancement quantification in post-operative MRI as an indicator of residual tumor impact is associated with survival in patients with glioblastoma |
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| المؤلفون: | Alonso Garcia-Ruiz, Mònica Cos, Nahum Calvo, Gerard Plans, Albert Pons-Escoda, Marta Ligero, Jordi Bruna, Raquel Perez-Lopez, Carles Majós, Pablo Naval-Baudin |
| المساهمون: | Institut Català de la Salut, [Garcia-Ruiz A, Ligero M] Radiomics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Naval-Baudin P] Department of Radiology, Institut de Diagnòstic Per La Imatge (IDI), Bellvitge University Hospital, Barcelona, Spain. [Pons-Escoda A] Department of Radiology, Institut de Diagnòstic Per La Imatge (IDI), Bellvitge University Hospital, Barcelona, Spain. Neuro Oncology Unit, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain. [Bruna J] Neuro Oncology Unit, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain. Department of Neurology, Bellvitge University Hospital, Barcelona, Spain. [Plans G] Neuro Oncology Unit, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain. Department of Neurosurgery, Bellvitge University Hospital, Barcelona, Spain. [Perez-Lopez R] Radiomics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei Radiodiagnòstic (IDI), Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientia Scientific Reports |
| بيانات النشر: | Springer Nature, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Neoplasm, Residual, Mathematics and computing, medicine.medical_treatment, Neurosurgical Procedures, Quimioteràpia, Image Processing, Computer-Assisted, Càncer de cap, Multidisciplinary, medicine.diagnostic_test, Brain Neoplasms, Confounding, Hazard ratio, Middle Aged, Prognosis, Magnetic Resonance Imaging, neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::neoplasias neuroepiteliales::glioma::astrocitoma::glioblastoma [ENFERMEDADES], Tumor Burden, Survival Rate, Neurology, Oncology, Medicine, Female, Radiology, medicine.drug, Adult, medicine.medical_specialty, Prognosi, Science, Brain tumor, Radioteràpia, Glioblastoma multiforme, Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma [DISEASES], Article, Head cancer, Young Adult, Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], medicine, Mortalitat, Humans, Chemotherapy, diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Mortality, Diagnosis::Prognosis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Survival rate, diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Aged, Retrospective Studies, Temozolomide, Radiotherapy, business.industry, Magnetic resonance imaging, Retrospective cohort study, medicine.disease, Imatgeria per ressonància magnètica, Glioblastoma, business, Follow-Up Studies |
| الوصف: | Matemàtiques i informàtica; Neurologia; Oncologia Matemáticas e informática; Neurología; Oncología Mathematics and computing; Neurology; Oncology Glioblastoma is the most common primary brain tumor. Standard therapy consists of maximum safe resection combined with adjuvant radiochemotherapy followed by chemotherapy with temozolomide, however prognosis is extremely poor. Assessment of the residual tumor after surgery and patient stratification into prognostic groups (i.e., by tumor volume) is currently hindered by the subjective evaluation of residual enhancement in medical images (magnetic resonance imaging [MRI]). Furthermore, objective evidence defining the optimal time to acquire the images is lacking. We analyzed 144 patients with glioblastoma, objectively quantified the enhancing residual tumor through computational image analysis and assessed the correlation with survival. Pathological enhancement thickness on post-surgical MRI correlated with survival (hazard ratio: 1.98, p |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc9f0b9ed5873b9430de151a7ab0176Test http://hdl.handle.net/2445/176176Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4bc9f0b9ed5873b9430de151a7ab0176 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |