Inflammatory Markers and Neuropsychological Functioning: The Framingham Heart Study
| العنوان: | Inflammatory Markers and Neuropsychological Functioning: The Framingham Heart Study |
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| المؤلفون: | Sudha Seshadri, Angela L. Jefferson, Alexa S. Beiser, Martin G. Larson, Emelia J. Benjamin, Philip A. Wolf, Joseph M. Massaro, Rhoda Au |
| المصدر: | Neuroepidemiology. 37:21-30 |
| بيانات النشر: | S. Karger AG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Epidemiology, Cross-sectional study, Ischemia, Disease, Neuropsychological Tests, Executive Function, Cognition, Framingham Heart Study, Memory, Internal medicine, medicine, Humans, Longitudinal Studies, Psychiatry, Aged, Aged, 80 and over, Inflammation, Original Paper, business.industry, Neuropsychology, Middle Aged, medicine.disease, Cross-Sectional Studies, Cytokines, Female, Neurology (clinical), business, Biomarkers |
| الوصف: | Background/Aims: We hypothesized that inflammatory markers are cross-sectionally and longitudinally associated with neuropsychological indicators of early ischemia and Alzheimer’s disease. Methods: Framingham Offspring Study participants, free of clinical stroke or dementia (n = 1,878; 60 ± 9 years; 54% women), underwent neuropsychological assessment and ascertainment of 11 inflammatory markers. Follow-up neuropsychological assessments (6.3 ± 1.0 years) were conducted on 1,352 of the original 1,878 participants. Results: Multivariable linear regression related the inflammatory markers to cross-sectional performance and longitudinal change in neuropsychological performances. Secondary models included a twelfth factor, tumor necrosis factor-α (TNF-α), available on a subset of the sample (n = 1,393 cross-sectional; n = 1,213 longitudinal). Results suggest a few modest cross-sectional inflammatory and neuropsychological associations, particularly for tests assessing visual organization (C-reactive protein, p = 0.007), and a few modest relations between inflammatory markers and neuropsychological change, particularly for executive functioning (TNF-α, p = 0.004). Secondary analyses suggested that inflammatory markers were cross-sectionally (TNF-α, p = 0.004) related to reading performance. Conclusions: Our findings are largely negative, but suggest that specific inflammatory markers may have limited associations with poorer cognition and reading performance among community-dwelling adults. Because of multiple testing concerns, our limited positive findings are offered as hypothesis generating and require replication in other studies. |
| تدمد: | 1423-0208 0251-5350 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b42f629f8f6f521532749a835db9129Test https://doi.org/10.1159/000328864Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b42f629f8f6f521532749a835db9129 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230208 02515350 |
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