Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
| العنوان: | Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis |
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| المؤلفون: | Hugo C. Castro-Faria-Neto, Flora Magno de Jesus Oliveira, Patrícia T. Bozza, Mauro Velho de Castro Faria, Patrícia Burth, Adriana R. Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Isabel M. Medeiros-de-Moraes |
| المصدر: | PLoS ONE PLoS ONE, Vol 11, Iss 4, p e0153607 (2016) |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Physiology, lcsh:Medicine, Gene Expression, AMP-Activated Protein Kinases, Fatty Acids, Nonesterified, 030204 cardiovascular system & hematology, Kidney, Pathology and Laboratory Medicine, Biochemistry, Ion Channels, Fatty Acids, Monounsaturated, Mice, chemistry.chemical_compound, 0302 clinical medicine, AMP-activated protein kinase, Malondialdehyde, Plant Products, Medicine and Health Sciences, Uncoupling Protein 2, lcsh:Science, Beta oxidation, Multidisciplinary, biology, Reverse Transcriptase Polymerase Chain Reaction, Fatty Acids, Chemical Reactions, Agriculture, Hematology, Lipids, Body Fluids, Survival Rate, Chemistry, Blood, Liver, Physical Sciences, Anatomy, Oxidation-Reduction, Research Article, medicine.drug, medicine.medical_specialty, Blotting, Western, Lung injury, Vegetable Oils, Blood Plasma, Mitochondrial Proteins, 03 medical and health sciences, Signs and Symptoms, NEFA, Diagnostic Medicine, Sepsis, Albumins, Internal medicine, Oxidation, medicine, Animals, Carnitine, Carnitine O-Palmitoyltransferase, lcsh:R, Biology and Life Sciences, Proteins, Kidney metabolism, AMPK, Lipid Metabolism, Survival Analysis, Agronomy, Oleic acid, Metabolism, 030104 developmental biology, Endocrinology, chemistry, biology.protein, lcsh:Q, Reactive Oxygen Species, Oleic Acid, Crop Science |
| الوصف: | Sepsis is characterized by inflammatory and metabolic alterations, which lead to massive cytokine production, oxidative stress and organ dysfunction. In severe systemic inflammatory response syndrome, plasma non-esterified fatty acids (NEFA) are increased. Several NEFA are deleterious to cells, activate Toll-like receptors and inhibit Na+/K+-ATPase, causing lung injury. A Mediterranean diet rich in olive oil is beneficial. The main component of olive oil is omega-9 oleic acid (OA), a monounsaturated fatty acid (MUFA). We analyzed the effect of OA supplementation on sepsis. OA ameliorated clinical symptoms, increased the survival rate, prevented liver and kidney injury and decreased NEFA plasma levels in mice subjected to cecal ligation and puncture (CLP). OA did not alter food intake and weight gain but diminished reactive oxygen species (ROS) production and NEFA plasma levels. Carnitine palmitoyltransferase IA (CPT1A) mRNA levels were increased, while uncoupling protein 2 (UCP2) liver expression was enhanced in mice treated with OA. OA also inhibited the decrease in 5' AMP-activated protein kinase (AMPK) expression and increased the enzyme expression in the liver of OA-treated mice compared to septic animals. We showed that OA pretreatment decreased NEFA concentration and increased CPT1A and UCP2 and AMPK levels, decreasing ROS production. We suggest that OA has a beneficial role in sepsis by decreasing metabolic dysfunction, supporting the benefits of diets high in monounsaturated fatty acids (MUFA). |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5ba0549a8d5d340133ec38262b3469Test https://doi.org/10.1371/journal.pone.0153607Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a5ba0549a8d5d340133ec38262b3469 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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