Performance Related Factors Are the Main Determinants of the von Willebrand Factor Response to Exhaustive Physical Exercise
| العنوان: | Performance Related Factors Are the Main Determinants of the von Willebrand Factor Response to Exhaustive Physical Exercise |
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| المؤلفون: | Janine E. van Loon, Stephan F. E. Praet, Frank W.G. Leebeek, Moniek P.M. de Maat, Michelle A.H. Sonneveld |
| المساهمون: | Hematology, Rehabilitation Medicine |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 3, p e91687 (2014) PLoS One (print), 9(3). Public Library of Science |
| بيانات النشر: | Public Library of Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Epidemiology, Physical fitness, Glycobiology, lcsh:Medicine, Syntaxin 1, Biochemistry, R-SNARE Proteins, hemic and lymphatic diseases, Medicine, Clinical Epidemiology, lcsh:Science, Promoter Regions, Genetic, Multidisciplinary, biology, Weibel-Palade Bodies, Middle Aged, medicine.anatomical_structure, cardiovascular system, Female, Coagulation Factors, circulatory and respiratory physiology, Research Article, Cardiac function curve, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Endothelium, ADAMTS13 Protein, Physical exercise, Nerve Tissue Proteins, Syntaxin binding, Von Willebrand factor, Internal medicine, von Willebrand Factor, Weibel–Palade body, Genetics, Humans, Sports and Exercise Medicine, Antigens, Biology, Exercise, Genetic Association Studies, Glycoproteins, business.industry, lcsh:R, Proteins, Human Genetics, ADAM Proteins, Blood pressure, Endocrinology, Immunology, biology.protein, Genetic Polymorphism, lcsh:Q, business, Population Genetics |
| الوصف: | textabstractBackground: Physical stress triggers the endothelium to release von Willebrand Factor (VWF) from the Weibel Palade bodies. Since VWF is a risk factor for arterial thrombosis, it is of great interest to discover determinants of VWF response to physical stress. We aimed to determine the main mediators of the VWF increase by exhaustive physical exercise. Methods: 105 healthy individuals (18-35 years) were included in this study. Each participant performed an incremental exhaustive exercise test on a cycle ergometer. Respiratory gas exchange measurements were obtained while cardiac function was continuously monitored. Blood was collected at baseline and directly after exhaustion. VWF antigen (VWF:Ag) levels, VWF collagen binding (VWF:CB) levels, ADAMTS13 activity and common variations in Syntaxin Binding Protein-5 (STXBP5, rs1039084 and rs9399599), Syntaxin-2 (STX2, rs7978987) and VWF (promoter, rs7965413) were determined. Results: The median VWF:Ag level at baseline was 0.94 IU/mL [IQR 0.8-1.1] and increased with 47% [IQR 25-73] after exhaustive exercise to a median maximum VWF:Ag of 1.38 IU/mL [IQR 1.1-1.8] (p |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa51dbbee5a8a2b86e1a8bb9d51823dTest https://pure.eur.nl/en/publications/87f0b806-5840-4892-a164-5b05eec993fbTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8aa51dbbee5a8a2b86e1a8bb9d51823d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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