Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways
| العنوان: | Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways |
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| المؤلفون: | Michail S. Lionakis, Georgios Chamilos, Dimitrios P. Kontoyiannis |
| المصدر: | Clinical Infectious Diseases. 66:140-148 |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Microbiology (medical), 030106 microbiology, 03 medical and health sciences, chemistry.chemical_compound, Immune system, Piperidines, Humans, Medicine, Bruton's tyrosine kinase, Pneumocystis jirovecii, Sinusitis, Protein Kinase Inhibitors, Immunodeficiency, Aged, Aged, 80 and over, Cryptococcus neoformans, biology, business.industry, Kinase, Adenine, Fungi, Middle Aged, medicine.disease, biology.organism_classification, Small molecule, Viewpoints, Pyrimidines, 030104 developmental biology, Infectious Diseases, chemistry, Mucor, Hematologic Neoplasms, Ibrutinib, Immunology, biology.protein, Pyrazoles, Female, business, Immunosuppressive Agents, Invasive Fungal Infections, Signal Transduction |
| الوصف: | Opportunistic infections caused by Pneumocystis jirovecii, Cryptococcus neoformans, and ubiquitous airborne filamentous fungi have been recently reported in patients with hematological cancers historically considered at low risk for invasive fungal infections (IFIs), after receipt of the Bruton tyrosine kinase inhibitor ibrutinib. The spectrum and severity of IFIs often observed in these patients implies the presence of a complex immunodeficiency that may not be solely attributed to mere inhibition of Bruton tyrosine kinase. In view of the surge in development of small molecule kinase inhibitors for treatment of malignant and autoimmune diseases, it is possible that there would be an emergence of IFIs associated with the effects of these molecules on the immune system. Preclinical assessment of the immunosuppressive effects of kinase inhibitors and human studies aimed at improving patient risk stratification for development of IFIs could lead to prevention, earlier diagnosis, and better outcomes in affected patients. |
| تدمد: | 1537-6591 1058-4838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3ade529f0c45026327862e278756feTest https://doi.org/10.1093/cid/cix687Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a3ade529f0c45026327862e278756fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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