Prevalence and Correlates of Persistent HIV-1 RNA in Cerebrospinal Fluid During Antiretroviral Therapy
| العنوان: | Prevalence and Correlates of Persistent HIV-1 RNA in Cerebrospinal Fluid During Antiretroviral Therapy |
|---|---|
| المؤلفون: | Robert K. Heaton, Justin C. McArthur, Igor Grant, Ronald J. Ellis, Jose A. Muñoz-Moreno, Scott Letendre, J. Allen McCutchan, Debra Cookson, David M. Simpson, Ned Sacktor, Daniel R. McClernon, Susan Morgello, Benjamin B. Gelman, Albert M. Anderson, Ann C. Collier, David B. Clifford, Donald Franklin, Christina M. Marra |
| المصدر: | Journal of Infectious Diseases r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
| بيانات النشر: | Oxford University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Anti-HIV Agents, antiretroviral therapy, Neurocognitive Disorders, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Hiv 1 rna, cerebrospinal fluid, Major Articles and Brief Reports, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Immune system, Prevalence, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, Immune status, business.industry, virus diseases, RNA, HIV, Middle Aged, Viral Load, Virology, Antiretroviral therapy, CD4 Lymphocyte Count, Infectious Diseases, Immunology, HIV-1, cognitive disorders, RNA, Viral, Female, business, Viral load, 030217 neurology & neurosurgery |
| الوصف: | Author(s): Anderson, Albert M; Munoz-Moreno, Jose A; McClernon, Daniel R; Ellis, Ronald J; Cookson, Debra; Clifford, David B; Collier, Ann C; Gelman, Benjamin B; Marra, Christina M; McArthur, Justin C; McCutchan, J Allen; Morgello, Susan; Sacktor, Ned; Simpson, David M; Franklin, Donald R; Heaton, Robert K; Grant, Igor; Letendre, Scott L; CHARTER Group | Abstract: Background Neurocognitive disorders remain common among human immunodeficiency virus (HIV)-positive adults, perhaps owing to persistent HIV-1 RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART).Methods Using a single-copy assay, we measured HIV-1 RNA levels in CSF and plasma specimens from 220 HIV-positive adults who were taking suppressive ART. Fifty-five participants were tested twice.Results HIV-1 RNA was detected in 42.3% of CSF and 65.2% of plasma samples. Correlates of higher CSF HIV-1 RNA levels included higher nadir and current CD4+ T-cell counts, a plasma HIV-1 RNA level of ≥ 1 copy/mL, and a lower central nervous system penetration-effectiveness score (model P l .001). Worse neurocognitive performance was associated with discordance in HIV-1 RNA detection between plasma and CSF, lower overall CSF HIV-1 RNA level, and longer ART duration, among others (model P l .001). In the longitudinal subgroup, CSF HIV-1 RNA persisted in most participants (69%) over 7 months.Conclusions Low-level HIV-1 RNA in CSF is common during suppressive ART and is associated with low-level HIV-1 RNA in blood, better immune status, and lower ART drug distribution into CSF. The association between HIV-1 RNA discordance and HIV-associated neurocognitive disorder (HAND) may reflect compartmentalization. The relationship between HAND, lower HIV-1 RNA levels in CSF, and lower CD4+ T-cell counts may reflect disturbances in the immune response to HIV-1 in the CNS. |
| تدمد: | 1537-6613 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebd671457c38874b256ea9be9c0c502Test https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6372Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2ebd671457c38874b256ea9be9c0c502 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 |
|---|