Successful Treatment with Bedtime Basal Insulin Added to Metformin without Weight Gain or Hypoglycaemia over Three Years
| العنوان: | Successful Treatment with Bedtime Basal Insulin Added to Metformin without Weight Gain or Hypoglycaemia over Three Years |
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| المؤلفون: | Ulrich Müller, Bernardo Mertes, Michael Piorkowski, Sybille Gödde, Guido Kramer, Nadine Kuniss |
| المصدر: | Journal of Clinical Medicine Volume 9 Issue 4 Journal of Clinical Medicine, Vol 9, Iss 1153, p 1153 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | HBA1c target, medicine.medical_specialty, endocrine system diseases, lcsh:Medicine, 030209 endocrinology & metabolism, NPH insulin, Type 2 diabetes, Bedtime, Gastroenterology, Article, Therapeutic goal, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, ddc:610, basal insulin, 030212 general & internal medicine, business.industry, Basal insulin, lcsh:R, nutritional and metabolic diseases, General Medicine, medicine.disease, Metformin, medicine.symptom, metformin, business, Weight gain, hypoglycaemia, medicine.drug |
| الوصف: | The aim of this observational study was to follow-up patients with bedtime basal insulin (NPH insulin) added to metformin. In 285 patients with type 2 diabetes, a therapy with bedtime basal insulin added to metformin was started due to failure to achieve a glycaemic goal. Up until July 2019, 272 patients (95.4%) were followed-up (59.5 y, 92.6 kg, diabetes duration 6.6 y, HbA1c 8.4%/68.6 mmol/mol). HbA1c decreased by &minus 1.2% and bodyweight by &minus 1.7 kg after a duration of 31.7 ± 29.1 (range 2&ndash 133) months. Severe hypoglycaemia did not occur. In 144/272 patients (52.9%), the therapeutic goal for HbA1c was achieved over 32.7 months. In 69/272 patients (25.4%), the HbA1c target was achieved over 25.0 months (afterwards, therapy with basal insulin was discontinued because HbA1c was under target). In 36/272 patients (13.2%), the HbA1c goal was achieved until the submission of this manuscript (mean duration of treatment 57.4 ± 28.2 (range 13&ndash 121) months). Over 90% of patients with type 2 diabetes and failure of metformin reached their HbA1c goal with additional basal insulin at bedtime over several years in association with a reduction of bodyweight and without any event of severe hypoglycaemia. |
| وصف الملف: | application/pdf |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a216e094df59e0eeab26d712360ae0deTest https://doi.org/10.3390/jcm9041153Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a216e094df59e0eeab26d712360ae0de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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