Fatty acid acylated insulins display protracted action due to binding to serum albumin
| العنوان: | Fatty acid acylated insulins display protracted action due to binding to serum albumin |
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| المؤلفون: | Ib Jonassen, Svend Havelund, E. Hasselager, Ulla Ribel, Jan Markussen, J. Halstrom, Jean L. Whittingham, Peter Kurtzhals, Ulla D. Larsen |
| المصدر: | Peptide Science — Present and Future ISBN: 0792352718 |
| بيانات النشر: | Kluwer Academic Publishers, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | chemistry.chemical_classification, medicine.medical_specialty, biology, Chemistry, Insulin, medicine.medical_treatment, Albumin, Serum albumin, Fatty acid, NPH insulin, Ligand (biochemistry), Endocrinology, Pharmacokinetics, Internal medicine, medicine, biology.protein, Potency |
| الوصف: | The insulin example demonstrates that it is possible to alter pharmacokinetics and dynamics. By careful choice of ligand and site of substitution it is possible to provide the molecule with the desired characteristics without loosing potency. In this example the following characteristic of insulin has been obtained: 1. A prolonged acting insulin analogue which can be formulated as a neutral soluble preparation 2. Insulin has been provided with albumin binding properties 3. Improved duration of action compared to NPH insulin 4. Improved dynamic profile without sharp peeks of activity, i.e. smoother action |
| ردمك: | 978-0-7923-5271-6 0-7923-5271-8 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ca1b7e107cae692b3b04f506bac3b24cTest https://doi.org/10.1007/0-306-46864-6_227Test |
| رقم الانضمام: | edsair.doi...........ca1b7e107cae692b3b04f506bac3b24c |
| قاعدة البيانات: | OpenAIRE |
| ردمك: | 9780792352716 0792352718 |
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