Use of Insulin Glargine in Japanese Patients with Type 1 Diabetes
| العنوان: | Use of Insulin Glargine in Japanese Patients with Type 1 Diabetes |
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| المؤلفون: | Mitsuhiko Noda, Hiroji Kitazato, Masatoshi Kikuchi, Hiroshi Kajio, Yoko Hara, Ritsuko Yamamoto-Honda, Yasuo Akanuma, Yoko Yoshida, Takahisa Tanaka, Yoshihiko Takahashi, Atsuo Kawai |
| المصدر: | Internal Medicine. 46:937-943 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Insulin, Isophane, Insulin Glargine, NPH insulin, Risk Assessment, Severity of Illness Index, Gastroenterology, Drug Administration Schedule, Cohort Studies, Japan, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Insulin, Aged, Probability, Retrospective Studies, Glycemic, Analysis of Variance, Type 1 diabetes, Dose-Response Relationship, Drug, business.industry, Insulin glargine, General Medicine, Middle Aged, medicine.disease, Insulin, Long-Acting, Regimen, Diabetes Mellitus, Type 1, Treatment Outcome, Female, business, Body mass index, Follow-Up Studies, medicine.drug |
| الوصف: | Objective To evaluate the results of treatment with an insulin glargine-based regimen as compared with those of an NPH insulin-based regimen. Methods We reviewed the charts of 83 Japanese patients with Type 1 diabetes treated with insulin glargine for 12 months. Patients Median age, 56.9 years (range, 24.6-74.8 years), mean (+/-S.D.) body mass index, 21.2 (+/-2.2) kg/m2. Results The average HbA1c level of the cohort was 7.8 +/- 1.2% at baseline and 7.7 +/- 1.0% at the end of the 12-month treatment (P=0.34). The average insulin requirement per day in the cohort remained unchanged after the 12-month treatment (35.0 +/- 11.6 units/day versus 35.2 +/- 11.2 units/day (P=0.58). Of the 36 patients who were receiving twice or three times daily injections of NPH insulin, 30 could be switched to a single-daily injection of insulin glargine. The frequency of severe hypoglycemia with unconsciousness became lower after switching to the insulin glargine-based regimen than during treatment with the NPH-based regimen. The average ratio of the daily usage of insulin glargine to that of total insulin after 12 months was smaller than that reported from other countries (0.34 +/- 0.09). Conclusion These results obtained from a larger number of patients as compared to previous Japanese studies confirm earlier reports that insulin glargine provides equivalent glycemic control to human NPH insulin, with a lower incidence of severe hypoglycemia. Thus, treatment with insulin glargine provides some benefits to Japanese patients with Type 1 diabetes. |
| تدمد: | 1349-7235 0918-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb06edb6e8fec7b7d5c3d390c7cb2b9Test https://doi.org/10.2169/internalmedicine.46.6467Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1fb06edb6e8fec7b7d5c3d390c7cb2b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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