Long-Term Efficacy of Insulin Glargine After Switching from NPH Insulin as Intensive Replacement of Basal Insulin in Japanese Diabetes Mellitus. Comparison of Efficacy between Type 1 and Type 2 diabetes (JUN-LAN Study 1.2)
| العنوان: | Long-Term Efficacy of Insulin Glargine After Switching from NPH Insulin as Intensive Replacement of Basal Insulin in Japanese Diabetes Mellitus. Comparison of Efficacy between Type 1 and Type 2 diabetes (JUN-LAN Study 1.2) |
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| المؤلفون: | Ryuzo Kawamori, Yasushi Tanaka, Takahisa Hirose, Yuko Sakurai, Yoshie Kanazawa, Hirotaka Watada, Koji Komiya, Yasuhiro Igarashi, Yoshio Fujitani, Tomoaki Shimizu |
| المصدر: | Endocrine Journal. 54:975-983 |
| بيانات النشر: | Japan Endocrine Society, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulin, Isophane, Insulin Glargine, NPH insulin, Type 2 diabetes, Hypoglycemia, Endocrinology, Japan, Diabetes mellitus, Internal medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Longitudinal Studies, Prospective Studies, Glycemic, Glycated Hemoglobin, Insulin glargine, business.industry, Blood Glucose Self-Monitoring, Middle Aged, medicine.disease, Insulin, Long-Acting, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Basal (medicine), Female, business, medicine.drug |
| الوصف: | To assess and compare the efficacy and safety of insulin glargine as intensive replacement of basal insulin in Japanese patients with type 1 (n = 72) and type 2 (n = 46) diabetes, we switched their intensive insulin regimen from NPH plus regular or rapid-acting insulin to glargine plus bolus insulin, which included regular and rapid-acting insulin, and recorded changes in glycemic control and frequency of hypoglycemia for 18 months. The dose titration of basal and bolus insulin was based on home self-monitored blood glucose measurements and monthly HbA(1C). Mean HbA(1C) level was improved significantly at 3 months after switching to glargine plus bolus insulin regimen and these effects continued for 18 months in both type 1 and type 2 diabetes patients (HbA(1C) level: type 1: baseline 8.9 +/- 2.6%, 18 months 7.8 +/- 1.5% (p |
| تدمد: | 1348-4540 0918-8959 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd42c331a422fa4a596925a409bacaeTest https://doi.org/10.1507/endocrj.k07e-035Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cbd42c331a422fa4a596925a409bacae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484540 09188959 |
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