Mechanism of oxidative damage in Escherichia coli caused by epigallocatechin gallate (EGCG) in the presence of calcium ions
| العنوان: | Mechanism of oxidative damage in Escherichia coli caused by epigallocatechin gallate (EGCG) in the presence of calcium ions |
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| المؤلفون: | Cuimin Feng, Jia-cheng Luo, Xuan-qi Liu, Lu-meng Huang, Hong-ying Yu, Chang-zheng Wang, Jin-shuang Zhang |
| المصدر: | Journal of Water Supply: Research and Technology-Aqua. |
| بيانات النشر: | IWA Publishing, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Environmental Engineering, Health, Toxicology and Mutagenesis, Water Science and Technology |
| الوصف: | Tea polyphenols can be developed into new types of disinfectants for drinking water. The antibacterial effect of epigallocatechin gallate (EGCG) on Escherichia coli (E. coli) in the presence of Ca2+ is affected by the Ca2+ concentration. The oxidative damage mechanism and oxidative damage process of EGCG in E. coli under the presence of Ca2+ were deeply analyzed under three aspects: reactive oxygen species (ROS), antioxidant system, and oxidative stress response in E. coli to provide a theoretical basis for the use of EGCG as a disinfectant in drinking water disinfection. EGCG leads to excessive production of superoxide anion in E. coli and the presence of Ca2+ promotes further imbalance of superoxide anion in E. coli; Ca2+ has little effect on EGCG hindering the scavenging of hydroxyl radicals in bacteria; EGCG can hinder the effect of antioxidant enzymes in E. coli, and Ca2+ has a particular regulatory effect on antioxidant enzymes, thus hindering the oxidative damage of EGCG to E. coli; Ca2+ can cause the expression of the oxyR and DPS genes, protect bacterial DNA, and prevent EGCG from damaging bacterial DNA. In the presence of a high concentration of Ca2+, it may activate the cell efflux pump through the soxS gene, resulting in E. coli resistance to EGCG. |
| تدمد: | 1605-3974 0003-7214 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a1e66620e8e541a49887eb55966c81ceTest https://doi.org/10.2166/aqua.2023.190Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........a1e66620e8e541a49887eb55966c81ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16053974 00037214 |
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