Anti-hemolytic and Anti-cytotoxic Effect of Two Artemisia Species (A. campestris and A. herba-alba) Essential Oil against Snake Venom
| العنوان: | Anti-hemolytic and Anti-cytotoxic Effect of Two Artemisia Species (A. campestris and A. herba-alba) Essential Oil against Snake Venom |
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| المؤلفون: | Imed Hassen, Sana Riabi-Ayari, Zaineb Abdelkafi-Koubaa, Mbarka Tej Yakoubi, Naziha Marrakchi, Ichrak Jaouadi, Mohamed El Gazzah, Mohamed El Ayeb |
| المساهمون: | Université de Tunis El Manar (UTM), Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Laboratoire des méthodes et techniques d'analyses, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Faculté de Médecine de Tunis |
| المصدر: | International Journal of Agriculture and Biology International Journal of Agriculture and Biology, 2016, 18 (4), pp.805-812. ⟨10.17957/IJAB/15.0174⟩ |
| بيانات النشر: | Friends Science Publishers, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 5-dimethylthiazol-2- yl)-2, OPD: o-phenylenediamine, 0301 basic medicine, Snake venom, E2: Artemesia herba-alba essential oil, [SDV]Life Sciences [q-bio], Venom, E1: Artemesia campestris essential oil, complex mixtures, law.invention, 03 medical and health sciences, law, Botany, GC–MS: Gas chromatography-mass spectrometry, Cytotoxicity, 5-diphenyltetrazolium bromide, Essential oil, HMEC-1 cells: Human Microvascular Endothelial Cell, LD50: lethal dosage value, SDS: sodium dodecyl sulfate, biology, Traditional medicine, MiHD: The minimum indirect hemolytic dose, food and beverages, Cerastes cerastes, biology.organism_classification, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, 3. Good health, 030104 developmental biology, Artemisia, Essential oils, Polyphenol, Toxicity, cytotoxicity, MTT: 3-(4, lethality Abbreviation: BPB: Bromophenol blue, General Agricultural and Biological Sciences, C c: Cerastes cerastes venom |
| الوصف: | In this study, we verify the possible activity of Artemisia herba-alba and A. campestris (Asteraceae) essential oil against the snake venoms. The leaves of A. campestris has been used in the folk medicine against snake moisture. The aerial part extracts of both plants have been tested for their action against snake venom. Interaction of A. campestris (E1) and A. herba alba (E2) essential oils with proteins extracted from snake venom has been tested. Lethality in mice, inflammation and cytotoxicity induced by Cerastes cerastes venoms were significantly inhibited by the mixture of different amounts of E1 and E2 and the venom. However, both extracts showed neutralization of the venoms hemolytic activity which is more important with E2. Chemical characterization of E1 and E2 revealed there is an important amount of polyphenols and tannins which are known by their bio-active effect. The result could lead as to think that these components have an action by inhibiting the toxicity of snake venoms in vitro. We can conclude therefore that the use of the essential oil from the two Artemisia species have a curative effect on the snake venom. These results confirmed the traditional use of A. campestris and we discovered a similar effect of A. herba-alba. No data have been reported till now about the essential oil curative effect of both species. © 2016 Friends Science Publishers |
| تدمد: | 1814-9596 1560-8530 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22620c0cdfd8c94c2c5fd10dc81132c7Test https://doi.org/10.17957/ijab/15.0174Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....22620c0cdfd8c94c2c5fd10dc81132c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18149596 15608530 |
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