Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
| العنوان: | Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma |
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| المؤلفون: | Colleen M. Connelly, Alexander Deiters, Christoph Grohmann, Douglas D. Young |
| المصدر: | Journal of the American Chemical Society. 132:7976-7981 |
| بيانات النشر: | American Chemical Society (ACS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Enoxacin, Carcinoma, Hepatocellular, Hepatitis C virus, Apoptosis, Virus Replication, medicine.disease_cause, Biochemistry, Catalysis, Colloid and Surface Chemistry, microRNA, MiR-122, medicine, Humans, Base Sequence, Chemistry, Liver Neoplasms, Cancer, General Chemistry, Oligonucleotides, Antisense, medicine.disease, Hepatitis C, Small molecule, MicroRNAs, Viral replication, Hepatocellular carcinoma, Cancer research, Liver cancer, HeLa Cells |
| الوصف: | MicroRNAs are a recently discovered new class of important endogenous regulators of gene function. Aberrant regulation of microRNAs has been linked to various human diseases, most importantly cancer. Small molecule intervention of microRNA misregulation has the potential to provide new therapeutic approaches to such diseases. Here, we report the first small molecule inhibitors and activators of the liver-specific microRNA miR-122. This microRNA is the most abundant microRNA in the liver and is involved in hepatocellular carcinoma development and hepatitis C virus (HCV) infection. Our small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections. Moreover, small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy. In addition to providing a new approach for the development of therapeutics, small molecule modifiers of miR-122 function are unique tools for exploring miR-122 biogenesis. |
| تدمد: | 1520-5126 0002-7863 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3765ae1b82d8ce7423dee69052ede73Test https://doi.org/10.1021/ja910275uTest |
| رقم الانضمام: | edsair.doi.dedup.....a3765ae1b82d8ce7423dee69052ede73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205126 00027863 |
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