دورية أكاديمية
Role of Pterostilbene in Metabolic Diseases through SIRT1 pathway- A Review
| العنوان: | Role of Pterostilbene in Metabolic Diseases through SIRT1 pathway- A Review |
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| المؤلفون: | Rashmi Patil, Urmila Aswar |
| المصدر: | Turkish Journal of Agriculture: Food Science and Technology, Vol 9, Iss sp, Pp 2581-2586 (2021) |
| بيانات النشر: | Turkish Science and Technology Publishing (TURSTEP), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Agriculture LCC:Agriculture (General) |
| مصطلحات موضوعية: | pterostilbene, sirt1, diabetes, obesity, inflammation, insulin resistance, Agriculture, Agriculture (General), S1-972 |
| الوصف: | Pterostilbene (PTE) (3-5 dimethoxy-4-hydroxy-trans-stilbenes) is an analogue of resveratrol. It is extracted and isolated from a natural source of the heartwood of Pterocarpus marsupium Roxb., red grape skin, and blueberries (Vaccinium spp.). Substantial evidence suggested that PTE displayed numerous preventive and therapeutic properties in many metabolic disorders such as diabetes and obesity. Metabolic diseases result in Insulin resistance (IR) which advances to impaired sensitivity to insulin-mediated glucose disposal. The prominent role of SIRT (silent information regulator proteins) is now getting emphasized in metabolic disorders. SIRT1 represses Uncoupling protein 2 (UCP2) expressions which are further responsible for improving synthesis of ATP from glucose. This results in improving glucose utilization and insulin secretion, thus preventing IR. SIRT1 also exhibits prominent role in facilitating fatty acid mobilization thereby inhibiting adiposity. Metabolic disorders are therefore the consequences of SIRT1 downregulation. Pterostilbene, being a SIRT1 activator, increases insulin sensitivity reduces adiposity, therefore can prove to be beneficial in diabetes as well as obesity. The review summarizes therapeutic effects portrayed by Pterostilbene via the SIRT1 pathway in metabolic diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Turkish |
| تدمد: | 2148-127X |
| العلاقة: | http://www.agrifoodscience.com/index.php/TURJAF/article/view/4938Test; https://doaj.org/toc/2148-127XTest |
| DOI: | 10.24925/turjaf.v9isp.2581-2586.4938 |
| الوصول الحر: | https://doaj.org/article/d508fc88fa714079891546e6be817d68Test |
| رقم الانضمام: | edsdoj.508fc88fa714079891546e6be817d68 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 2148127X |
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| DOI: | 10.24925/turjaf.v9isp.2581-2586.4938 |