دورية أكاديمية
أعرض في EDS

Reduced serum sRANKL and sTREM2 levels in high-grade gliomas: association with prognosis ; Yüksek dereceli gliomalarda azalmış serum sRANKL ve sTREM2 seviyeleri: prognoz ile ilişkisi

التفاصيل البيبلوغرافية
العنوان: Reduced serum sRANKL and sTREM2 levels in high-grade gliomas: association with prognosis ; Yüksek dereceli gliomalarda azalmış serum sRANKL ve sTREM2 seviyeleri: prognoz ile ilişkisi
المساهمون: Türkoğlu, Ceren, Efendioğlu, Mustafa, Şanlı, Elif, Balak, Naci, School of Medicine
المصدر: Archives of Neuropsychiatry / Nöropsikiyatri Arşivi
بيانات النشر: Turkish Neuropsychiatry Association / Türk Nöropsikiyatri Derneği
National
سنة النشر: 2021
المجموعة: Koç University Suna Kıraç Library’ Digital Collections
مصطلحات موضوعية: Neurosciences and neurology, Glioblastoma multiforme, Glioma, Soluble receptor activator for nuclear factor-kappa B ligand (sRANKL), Soluble triggering receptor expressed on myeloid cells 2 (sTREM2)
الوصف: Introduction: high-grade gliomas (HGG), including Glioblastoma multiforme (GBM), account for the majority of primary brain tumors. Nevertheless, prognostic and diagnostic biomarkers are quite limited for HGG. The objective of this study was to investigate the prognostic value of sRANKL and sTREM2 levels in HGG patients. Methods: twelve consecutive patients with HGG, 14 patients with non-glial tumors (non-GT) and 20 age and gender-matched healthy controls were recruited. Overall survival duration of the patients was recorded. Pre-operative serum levels of sRANKL and sTREM2 were measured by ELISA. Tumors of HGG patients were analyzed by immunohistochemical staining for p53 and Ki67 and percentage scores were calculated. Results: patients with HGG and non-GT showed lower serum sRANKL and sTREM2 levels than healthy individuals. Levels of sRANKL were inversely correlated with the overall survival of patients (p=0.002, R=0.787), while sTREM2 levels were inversely correlated with p53 score (p=0.018, R=-0.666) but not survival. Conclusion: brain tumor patients show suppressed levels of filial activity biomarkers in the peripheral circulation. Serum sRANKL levels may serve as a potential prognostic biomarker for HGG. / Amaç: glioblastoma multiforme (GBM) dâhil olmak üzere yüksek dereceli gliomalar (YDG), birincil beyin tümörlerinin çoğunluğunu oluşturur. Bununla birlikte, tanısal ve prognostik biyobelirteçler YDG için oldukça sınırlıdır. Bu çalışmanın amacı, YDG hastalarında sRANKL vesTREM2 düzeylerinin prognostik değerini araştırmaktır. Yöntem: çalışmaya 12 YDG hastası, 14 tümörü glial (GT) kaynaklı olmayan hasta ile 20 yaş ve cinsiyet uyumlu sağlıklı kontrol dâhil edildi. Hastaların genel sağkalım süreleri kaydedildi. sRANKL ve sTREM2’ninoperasyon öncesi serum seviyeleri ELISA yöntemi ile ölçüldü. YDG hastalarının tümörleri p53 ve Ki67 için immünohistokimyasal boyama ile analiz edilerek yüzde skorları hesaplandı. Bulgular: YDG’si olan ve GT olmayan hastalar, sağlıklı bireylere göre daha düşük serum sRANKL ve sTREM2 ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: text/academic publication
اللغة: English
Turkish
تدمد: 1300-0667
1309-4866
العلاقة: Publisher version; Koç University Institutional Repository; Efendioglu, Mustafa, Elif Sanli, Ceren Turkoglu, and Naci Balak. "Reduced Serum Srankl and Strem2 Levels in High-Grade Gliomas: Association with Prognosis." Archives of Neuropsychiatry. (2020).; https://dx.doi.org/10.29399/npa.27536Test / https://www.noropsikiyatriarsivi.com/sayilar/2021/haziran/58_2/en/npa_v58_n2_133-136.pdfTest / https://www.noropsikiyatriarsivi.com/sayilar/2021/haziran/58_2/tr/npa_c58s2_133-136.pdfTest; WoS; Scopus; Pubmed; TR Dizin; NA; http://libdigitalcollections.ku.edu.tr/cdm/ref/collection/IR/id/9671Test
DOI: 10.29399/npa.27536
الإتاحة: https://doi.org/10.29399/npa.27536Test
http://libdigitalcollections.ku.edu.tr/cdm/ref/collection/IR/id/9671Test
رقم الانضمام: edsbas.A7933D13
قاعدة البيانات: BASE
الوصف
تدمد:13000667
13094866
DOI:10.29399/npa.27536