The levels of fetuin-a, osteopontin, total antioxidant and oxidant in patients with midline closure defects
| العنوان: | The levels of fetuin-a, osteopontin, total antioxidant and oxidant in patients with midline closure defects |
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| المؤلفون: | Gulyara Çiğdem, Hamza Karabağ, Ismail Koyuncu |
| المصدر: | Volume: 16, Issue: 2 300-304 Harran Üniversitesi Tıp Fakültesi Dergisi |
| بيانات النشر: | Harran Üniversitesi, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, Embryogenesis, Orta Hat Defekti,oksidatif stres,Osteopontin,Fetuin-A, Neural tube, Closure Defect,oxidative stress,Osteopontin,Fetuin-A, Spinal cord, medicine.disease, medicine.disease_cause, Gastroenterology, Hydrocephalus, Tıp, Spina bifida occulta, medicine.anatomical_structure, Internal medicine, Automotive Engineering, medicine, Mann–Whitney U test, biology.protein, Medicine, Osteopontin, business, Oxidative stress |
| الوصف: | Amaç: Orta Hat kapanma Defekti (OHD) yüksek morbidite ve mortalite ileilişkili doğumsal spinal omurgaların birleşme kusurudur. OHD’li olan hastalardaFetuin-A, Osteopontin, Total antioksidan ve oksidan seviyeleri bilinmemektedir.Bu çalışmada bu paramatrelerin OHD’li olan hastalarda düzeyleri ve hastalıklaolan ilişkisi araştırıldı.Materyal veMetot: Çalışmaya, 0-5 yaş grubuarasında OHD olan hastalar (Çalışma grubu, n=80) ve benzer yaşta sağlıklıçocuklar (Kontrol grubu, n=85) olmak üzere 165 olgu alındı. OHD olan olgularSpina Bifida Occulta (Grup I, n=22), Spinal Meningosel veya Miyelomeningosel(Grup 2, n=26) ve Hidrosefalisi olan (Grup 3, n=31) olmak üzere 3 grubaayrıldı. Dağılımların normal olup olmadığı tek yönlü Kolmogorov–Smirnov testiile değerlendirildi. Gruplar arası karşılaştırmalarda, ki-kare, student ttesti, Mann-Whitney U testi ve Kruskal-Wallis varyans testleri kullanıldı. Tümolgularda Fetuin-A ve Osteopontin sandviç enzim bağlantılı immün sistemi emiciteknolojiye dayanarak ölçüldü, Total Antioksidan Status (TAS) ve Total OksidanStatus (TOS) spektrofotometrik olarakölçüldü. TOS’un TAS’a oranıyla oksidatifstres indeksi (OSİ) hesaplandı.Bulgular: Hasta ve kontrol grupları arasında TAS düzeyleri benzerdi (p=0.230).TOS ve OSİ düzeyleri hastalarda, Fetuin-A ve Osteopontin değerleri ise kontrolgrubunda daha yüksek bulundu (hepsi için, p Background: Midline closure defect malformation (NTD) is a congenital fusionaldefect of the posterior segments of spinal vertebrae which is associated withhigh morbidity and mortality. Fetuin-A, Osteopontin, total antioxidant andoxidant levels are unknown in patients with midline closure defects. In thisstudy, the levels of these parameters in patients with NTD and theirrelationship with the disease were investigated.Methods:The study included 165 patients (0-5 age group) with OHD (Study group, n = 80)and healthy children of similar age (Control group, n = 85). Patients with OHDwere divided into three groups as Spina Bifida Occulta (Group I, n = 22),Spinal Meningocele or Myelomeningocele (Group 2, n = 26) and Hydrocephalus(Group 3, n = 31). One-way Kolmogorov-Smirnov test was used to determinewhether the distributions were normal or not. Ki-square, student t test,Mann-Whitney U test and Kruskal-Wallis variance tests were used in thecomparisons between the groups. Total antioxidant status (TAS) and totaloxidant status (TOS) were measured spectrophotometrically. Oxidative stressindex (OSI) was calculated with the ratio of TOS to TAS.Results:TAS levels were similar between patient and control groups (p = 0.230). TOS andOSI levels were higher in patients, and fetuin-A and osteopontin values werehigher in the control group (for all, p |
| وصف الملف: | application/pdf |
| اللغة: | Turkish |
| تدمد: | 1304-9623 1309-4025 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87042bd522869d0156533951c0a4eb3bTest https://dergipark.org.tr/tr/pub/hutfd/issue/47757/571264Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87042bd522869d0156533951c0a4eb3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13049623 13094025 |
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