دورية أكاديمية
Effects of granisetron on spinal anesthesia-induced hypotension
| العنوان: | Effects of granisetron on spinal anesthesia-induced hypotension |
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| المؤلفون: | Alptekin, A., ÇataroÄŸlu, C.K., Gezer, A., Sayın, M., Dönmez, A. |
| بيانات النشر: | Anestezi Dergisi |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Granisetron, Article, blood pressure measurement, bradycardia, controlled study, demography, drug effect, elective surgery, fifth lumbar vertebra, fourth lumbar vertebra, heart rate, human, hypotension, induced hypotension, major clinical study, nausea and vomiting, Arterial pressure, Spinal anaesthesia, bupivacaine, placebo, sodium chloride, prophylaxis, randomized controlled trial, spinal anesthesia |
| الوصف: | Objective: It was aimed to evaluate the effect of intravenous (IV) granisetron used for nausea and vomiting prophylaxis on hypotension and bradycardia caused by spinal anesthesia. Methods: 120 ASA 1-2 patients undergoing elective surgery under spinal anesthesia were randomly divided into Group G (Ganisetron; n=60) and Group P (Placebo; n=60) groups. Five minutes before spinal anesthesia, Group G received 1 mg intravenous granisetron diluted in 10 mL of isotonic sodium chloride solution and Group P received 10 mL of isotonic sodium chloride solution. Spinal anesthesia with hyperbaric bupivacaine 0.5%, 15 mg at the level of L4-5 was applied for both groups. Hemodynamic data, sensory and motor block parameters were recorded before and after spinal anaesthesia every 5 minutes during 20 minutes of surgery. Results: There was no difference in the demographic data of both groups. Although hemodynamic data showed a decrease in both groups according to initial values, blood pressure measurements in group G were significantly higher than the first measure values. There was no significant difference in heart rate values between the groups. Conclusion: Intravenous granisetron reduces hypotension after spinal anesthesia, but it has no significant effect on heart rate. © Copyright Anesthesiology and Reanimation Specialists’ Society. This journal published by Logos Medical Publishing. Licenced by Creative Commons Attribution 4.0 International (CC) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | Turkish |
| تدمد: | 1300-0578 |
| العلاقة: | Anestezi Dergisi; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.11851/8202Test; https://doi.org/10.5222/jarss.2021.53825Test; 29; 132; 139; 2-s2.0-85114063944; Q4 |
| DOI: | 10.5222/jarss.2021.53825 |
| الإتاحة: | https://doi.org/20.500.11851/820210.5222/jarss.2021.53825Test https://hdl.handle.net/20.500.11851/8202Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.E0CB200A |
| قاعدة البيانات: | BASE |
| تدمد: | 13000578 |
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| DOI: | 10.5222/jarss.2021.53825 |