التفاصيل البيبلوغرافية
| العنوان: |
HPV INTEGRATION AND CERVICAL CANCER ; Integración viral y cáncer de cuello uterino |
| المؤلفون: |
López, Jacqueline, Aristizabal G, Fabio A |
| المصدر: |
Revista Colombiana de Ciencias Químico-Farmacéuticas; Vol. 35 Núm. 1 (2006) ; Revista Colombiana de Ciencias Químico-Farmacéuticas; v. 35 n. 1 (2006) ; Revista Colombiana de Ciencias Químico-Farmacéuticas; Vol. 35 No. 1 (2006) ; 1909-6356 ; 0034-7418 |
| بيانات النشر: |
Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmacia |
| سنة النشر: |
2006 |
| المجموعة: |
Universidad Nacional de Colombia: Portal de Revistas UN |
| مصطلحات موضوعية: |
human papillomavirus, viral integration, cervical cancer, high grade squamous intraepithelial lesions, virus del papiloma humano, integración viral, cáncer de cuello uterino, lesiones intraepiteliales de alto grado |
| الوصف: |
Cervical cancer is the second most prevalent cancer worldwide and is the second leading cause of cancer deaths in women. Persistent infection with high-risk human papillomaviruses (HPVs) types are the causative agents of cervical cancer, since 99% of tumors are positive for HPV DNA, HPV is a necessary cause of invasive cervical cancer worldwide. One of the key events of HPV-induced carcinogenesis is the integration of the HPV genome into a host chromosome, related with precancerous lesions progression. Integration follows a more specific pattern with respect to the HPV genome, expression of the viral E6 and E7 genes is consistently maintained, whereas other positions of the viral DNA are deleted or their expression is disturbed, like E2 gene. Loss of expression of the HPV E2 transcriptional repressor is significant and may be critical for malignant progression, as it may result in increased HPV E6 and E7 expression. The HPV E6 and E7 oncoproteins inactivate the p53 and pRB tumor suppressors; expression of high-risk HPV E6/E7 oncogenes provides a subset of the minimally required carcinogenic hits for full transformation of human epithelial cells. There is also evidence for deregulated HPV-16 E6-E7 mRNA stability after integration and specific alterations of host cellular gene expression have been detected upon HPV genome integration. Currently, integration of HPV is considered to be an important genetic alteration for the progression of intraepithelial lesions to invasive disease with potential clinical applications like mark tumour progression and diagnostic tool. ; El cáncer de cuello uterino (CCU) constituye un problema generalizado de salud que ocupa el segundo lugar a nivel mundial entre las neoplasias malignas de la mujer. Las infecciones persistentes con virus del papiloma humano (VPH) de alto riesgo son reconocidas actualmente como un factor necesario en el desarrollo de CCU y sus lesiones precursoras. Uno de los procesos que parece estar más involucrado en el origen de las células malignas, es el evento ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf; application/msword |
| اللغة: |
Spanish; Castilian |
| العلاقة: |
https://revistas.unal.edu.co/index.php/rccquifa/article/view/1591/2253Test; https://revistas.unal.edu.co/index.php/rccquifa/article/view/1591/2256Test; https://revistas.unal.edu.co/index.php/rccquifa/article/view/1591Test |
| الإتاحة: |
https://revistas.unal.edu.co/index.php/rccquifa/article/view/1591Test |
| حقوق: |
Derechos de autor 2006 Revista Colombiana de Ciencias Químico-Farmacéuticas ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.32FBF12F |
| قاعدة البيانات: |
BASE |
