The association between childhood maltreatment and empathic perspective taking is moderated by the 5-HTT linked polymorphic region: Another example of 'differential susceptibility'
| العنوان: | The association between childhood maltreatment and empathic perspective taking is moderated by the 5-HTT linked polymorphic region: Another example of 'differential susceptibility' |
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| المؤلفون: | Flasbeck, Vera, Moser, Dirk, Pakusch, Johanna, Kumsta, Robert, Brüne, Martin |
| المصدر: | PLoS ONE, Vol 14, Iss 12, p e0226737 (2019) PLoS ONE |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Biogenic Amines, Serotonin, Heterozygote, Psychometrics, Adolescent, Science, Emotions, DNA transcription, Social Sciences, Psychological Stress, Biochemistry, Personality Disorders, Polymorphism, Single Nucleotide, Borderline Personality Disorder, Mental Health and Psychiatry, Medicine and Health Sciences, Genetics, Psychology, Humans, Child Abuse, Serotonin Plasma Membrane Transport Proteins, Behavior, Mood Disorders, Depression, Neurosciences & comportement [H07] [Sciences sociales & comportementales, psychologie], Biology and Life Sciences, Neurochemistry, Neurotransmitters, Middle Aged, Medicine, Female, Gene expression, Neurosciences & behavior [H07] [Social & behavioral sciences, psychology], Empathy, Research Article, Neuroscience |
| الوصف: | Previous research has suggested that the short (S)-allele of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) may confer "differential susceptibility" to environmental impact with regard to the expression of personality traits, depressivity and impulsivity. However, little is known about the role of 5-HTTLPR concerning the association between childhood adversity and empathy. Here, we analyzed samples of 137 healthy participants and 142 individuals diagnosed with borderline personality disorder (BPD) focusing on the 5-HTTLPR genotype (S/L-carrier) and A/G SNP (rs25531), in relation to childhood maltreatment and empathy traits. Whereas no between-group difference in 5-HTTLPR genotype distribution emerged, the S-allele selectively moderated the impact of childhood maltreatment on empathic perspective taking, whereby low scores in childhood trauma were associated with superior perspective taking. In contrast, L-homozygotes seemed to be largely unresponsive to variation in environmental conditions in relation to empathy, suggesting that the S-allele confers "differential susceptibility". Moreover, a moderation analysis and tests for differential susceptibility yielded similar results when transcriptional activity of the serotonin transporter gene was taken into account. In conclusion, our findings suggest that the S-allele of the 5-HTTLPR is responsive to early developmental contingencies for "better and worse", i.e. conferring genetic plasticity, especially with regard to processes involving emotional resonance. |
| اللغة: | Sino-Tibetan languages |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a6bf6f2b86bf85eb0518be46d89af485Test http://orbilu.uni.lu/handle/10993/47238Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....a6bf6f2b86bf85eb0518be46d89af485 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |