دورية أكاديمية
Prognostic significance of new biological markers in chronic lymphocytic leukaemia
| العنوان: | Prognostic significance of new biological markers in chronic lymphocytic leukaemia |
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| المؤلفون: | Gotić Mirjana, Čolović Milica, Bogdanović Andrija, Peruničić-Jovanović Maja, Kraguljac-Kurtović Nada, Leković Danijela, Mihaljević Biljana |
| المصدر: | Srpski Arhiv za Celokupno Lekarstvo, Vol 139, Iss 11-12, Pp 753-758 (2011) |
| بيانات النشر: | Serbian Medical Society, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | chronic lymphocytic leukaemia, CD38 antigen, ZAP-70, prognosis, Medicine |
| الوصف: | Introduction. Chronic lymphocytic leukaemia is a disease with heterogeneous clinical course and outcome. Some patients have a progressive course of the disease and require therapy immediately after the diagnosis, while others have a stable form without the need for treatment. Recently, two new biological markers, the expression of CD38 antigen and ZAP-70 have shown independent significance in the prognosis in CLL patients. Objective. The aim of our study was to evaluate the clinical value of CD38 antigen and ZAP-70 expression as predictors of the disease progression and to analyze the correlation of these markers with other B-CLL prognostic markers. Methods. We assessed the expression of CD38 antigens by flow cytometry on peripheral blood samples and the expression of ZAP-70 by immunohistochemistry on formalin-fixed bone marrow (BM) biopsies in 40 newly diagnosed B-CLL patients. Disease progression was defined by the period elapsed from diagnosis to the time to first treatment (TFT). Results. Expression of CD38 antigen correlated positively with ZAP-70 expression (Pearson, r=0.476; p=0.002). Also, correlation analysis results showed that a positive expression of CD38 and ZAP-70 statistically significantly correlated with unfavourable classical prognostic parameters, such as advanced Binet stage C, diffuse BM infiltration, increased lactate-dehydrogenase and beta-2 microglobulin serum levels. Patients with positive expression of CD38 antigen and ZAP-70 had a shorter TFT (log rank, 0.003 vs. 0.049). Conclusion. Both new biological markers were shown to have an exceptional significance in the prediction of prognosis in CLL patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Serbian |
| تدمد: | 0370-8179 |
| العلاقة: | https://doaj.org/toc/0370-8179Test |
| DOI: | 10.2298/SARH1112753L |
| الوصول الحر: | https://doaj.org/article/87db3b226ed84c1881f6502453149b84Test |
| رقم الانضمام: | edsdoj.87db3b226ed84c1881f6502453149b84 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 03708179 |
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| DOI: | 10.2298/SARH1112753L |