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1دورية أكاديمية
المؤلفون: R. S. Rakhmangulov
المصدر: Биотехнология и селекция растений, Vol 5, Iss 3, Pp 33-41 (2023)
مصطلحات موضوعية: ornamental crops, genetic editing, site-directed mutagenesis, crispr/cas, Biotechnology, TP248.13-248.65
وصف الملف: electronic resource
العلاقة: https://biosel.elpub.ru/jour/article/view/157Test; https://doaj.org/toc/2658-6266Test; https://doaj.org/toc/2658-6258Test
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2دورية أكاديمية
المؤلفون: V. V. Britikov, E. V. Britikova, E. V. Bocharov, Ya. V. Bershatsky, N. V. Kuzmina, K. M. Boyko, S. A. Usanov, В. В. Бритиков, Е. В. Бритикова, Э. В. Бочаров, Я. В. Бершацкий, Н. В. Кузьмина, К. М. Бойко, С. А. Усанов
المساهمون: The research is financially sponsored by the Belarusian Republican Foundation of Fundamental Research and the Russian Foundation of Basic Research (Projects No. Х20Р-159 and No. 20-54-00041Бел_а), Работа была выполнена при финансовой поддержке БРФФИ и РФФИ (проекты № Х20Р-159 и № 20-54-00041Бел_а)
المصدر: Doklady of the National Academy of Sciences of Belarus; Том 66, № 2 (2022); 176-186 ; Доклады Национальной академии наук Беларуси; Том 66, № 2 (2022); 176-186 ; 2524-2431 ; 1561-8323 ; 10.29235/1561-8323-2022-66-2
مصطلحات موضوعية: спектроскопия кругового дихроизма, human microsomal cytochrome b5, protein engineering, site-directed mutagenesis, hydroxylase activity, circular dichroism spectroscopy, микросомальный цитохром b5 человека, белковая инженерия, сайт-направленный мутагенез, гидроксилазная активность
وصف الملف: application/pdf
العلاقة: https://doklady.belnauka.by/jour/article/view/1052/1048Test; Guengerich, F. P. Human cytochrome P450 enzymes / F. P. Guengerich // Cytochrome P450. – Springer, Cham, 2015. – P. 597–607.; The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-Å resolution / J. K. Yano [et al.] // J. Biol. Chem. – 2004. – Vol. 279, N 37. – P. 38091–38094. https://doi.org/10.1074/jbc.c400293200Test; Ekroos, M. Structural basis for ligand promiscuity in cytochrome P450 3A4 / M. Ekroos, T. Sjögren // Proceedings of the National Academy of Sciences. – 2006. – Vol. 103, N 37. – P. 13682–13687. https://doi.org/10.1073/pnas.0603236103Test; Sevrioukova, I. F. Dissecting cytochrome P450 3A4–ligand interactions using ritonavir analogues / I. F. Sevrioukova, T. L. Poulos // Biochemistry. – 2013. – Vol. 52, N 26. – P. 4474–4481. https://doi.org/10.1021/bi4005396Test; Structure-based ligand design to overcome CYP inhibition in drug discovery projects / G. Brändén [et al.] // Drug Discovery Today. – 2014. – Vol. 19, N 7. – P. 905–911. https://doi.org/10.1016/j.drudis.2014.03.012Test; Sevrioukova, I. F. Anion-dependent stimulation of CYP3A4 monooxygenase / I. F. Sevrioukova, T. L. Poulos // Biochemistry. – 2015. – Vol. 54, N 26. – P. 4083–4096. https://doi.org/10.1021/acs.biochem.5b00510Test; Membrane-attached mammalian cytochromes P450: An overview of the membrane’s effects on structure, drug binding, and interactions with redox partners / M. Šrejber [et al.] // J. Inorg. Biochem. – 2018. – Vol. 183. – P. 117–136. https://doi.org/10.1016/j.jinorgbio.2018.03.002Test; Hackett, J. C. Membrane-embedded substrate recognition by cytochrome P450 3A4 / J. C. Hackett // J. Biol. Chem. – 2018. – Vol. 293, N 11. – P. 4037–4046. https://doi.org/10.1074/jbc.ra117.000961Test; Site‐specific labelling of proteins with a rigid lanthanide‐binding tag / X. C. Su [et al.] // ChemBioChem. – 2006. – Vol. 7, N 10. – P. 1599–1604. https://doi.org/10.1002/cbic.200600142Test; A Chiral Lanthanide Tag for Stable and Rigid Attachment to Single Cysteine Residues in Proteins for NMR, EPR and Time‐Resolved Luminescence Studies / I. D. Herath [et al.] // Chemistry – A European Journal. – 2021. – Vol. 27, N 51. – P. 13009–13023. https://doi.org/10.1002/chem.202101143Test; Site-specific fluorescent labeling and oriented immobilization of a triple mutant of CYP3A4 via C64 / A. Ménard [et al.] // Bioconjugate Chemistry. – 2012. – Vol. 23, N 4. – P. 826–836. https://doi.org/10.1021/bc200672sTest; Polic, V. Allosteric activation of cytochrome P450 3A4 via progesterone bioconjugation / V. Polic, K. Auclair // Bioconjugate Chemistry. – 2017. – Vol. 28, N 4. – P. 885–889. https://doi.org/10.1021/acs.bioconjchem.6b00604Test; Sevrioukova, I. F. High-level production and properties of the cysteine-depleted cytochrome P450 3A4 / I. F. Sevrioukova // Biochemistry. – 2017. – Vol. 56, N 24. – P. 3058–3067. https://doi.org/10.1021/acs.biochem.7b00334Test; Mechanism of interactions of α-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe / T. N. Tsalkova [et al.] // Biochemistry. – 2007. – Vol. 46, N 1. – P. 106–119. https://doi.org/10.1021/bi061944pTest; Effect of glutathione on homo-and heterotropic cooperativity in cytochrome P450 3A4 / D. R. Davydov [et al.] // Archives of Biochemistry and Biophysics. – 2008. – Vol. 471, N 2. – P. 134–145. https://doi.org/10.1016/j.abb.2008.01.001Test; Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET) / D. R. Davydov [et al.] // J. Biol. Chem. – 2012. – Vol. 287, N 9. – P. 6797–6809. https://doi.org/10.1074/jbc.m111.325654Test; A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET) / E. V. 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Chem. – 2011. – Vol. 286, N 7. – P. 5540–5545. https://doi.org/10.1074/jbc.m110.182055Test; https://doklady.belnauka.by/jour/article/view/1052Test
الإتاحة: https://doi.org/10.29235/1561-8323-2022-66-2-176-186Test
https://doi.org/10.29235/1561-8323-2022-66-2Test
https://doi.org/10.1074/jbc.c400293200Test
https://doi.org/10.1073/pnas.0603236103Test
https://doi.org/10.1021/bi4005396Test
https://doi.org/10.1016/j.drudis.2014.03.012Test
https://doi.org/10.1021/acs.biochem.5b00510Test
https://doi.org/10.1016/j.jinorgbio.2018.03.002Test
https://doi.org/10.1074/jbc.ra117.000961Test
https://doi.org/10.1002/cbic.200600142Test -
3دورية أكاديمية
المؤلفون: A. M. Korotkova, S. V. Gerasimova, E. K. Khlestkina
المصدر: Вавиловский журнал генетики и селекции, Vol 23, Iss 1, Pp 29-37 (2019)
مصطلحات موضوعية: biotechnology, crispr/cas, crop plants, genome editing, next-generation breeding, site-directed mutagenesis, target genes, Genetics, QH426-470
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: S. V. Gerasimova, A. M. Korotkova, C. Hertig, S. Hiekel, R. Hofe, N. Budhagatapalli, I. Otto, G. Hensel, V. K. Shumny, A. V. Kochetov, J. Kumlehn, E. K. Khlestkina
المصدر: Вавиловский журнал генетики и селекции, Vol 22, Iss 8, Pp 1033-1039 (2019)
مصطلحات موضوعية: crispr/cas, cas9, barley, protoplasts, nud, vrs1, regeneration, transfection, site-directed mutagenesis, in vitro culture, Genetics, QH426-470
وصف الملف: electronic resource
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5دورية أكاديمية
المؤلفون: A. M. Korotkova, S. V. Gerasimova, V. K. Shumny, E. K. Khlestkina
المصدر: Вавиловский журнал генетики и селекции, Vol 21, Iss 2, Pp 250-258 (2017)
مصطلحات موضوعية: cereals, gene catalogue, genome editing, fruits, new breeding tools, site-directed mutagenesis, plants, vegetables, Genetics, QH426-470
وصف الملف: electronic resource
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6دورية أكاديمية
المؤلفون: Pokrovskaya, M.V., Aleksandrova, S.S., Veselovsky, A.V., Zdanov, D.D., Pokrovsky, V.S., Eldarov, M.A., Grishin, D.V., Gladilina, Yu.A., Toropigin, I.Yu., Sokolov, N.N.
المصدر: Biomedical Chemistry: Research and Methods; Vol. 2 No. 1 (2019); e00071 ; Biomedical Chemistry: Research and Methods; Том 2 № 1 (2019); e00071 ; 2618-7531
مصطلحات موضوعية: L-аспарагиназа Rhodospirillum rubrum, сайт-направленный мутагенез, физико-химические свойства, L-asparaginase Rhodospirillum rubrum, site-directed mutagenesis, physical-chemical properties
وصف الملف: application/pdf; text/html
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7دورية أكاديمية
المؤلفون: Korchagina A.A., Shein S.A., Gurina O.I., Chekhonin V.P.
المصدر: Annals of the Russian academy of medical sciences; Vol 68, No 11 (2013); 104-114 ; Вестник Российской академии медицинских наук; Vol 68, No 11 (2013); 104-114 ; 2414-3545 ; 0869-6047 ; 10.15690/vramn6811
مصطلحات موضوعية: VEGF, VEGFR2, angiogenesis, inhibitors of angiogenesis, brain tumors, site-directed therapy, ангиогенез, ингибиторы ангиогенеза, опухоли мозга, направленная терапия
وصف الملف: application/pdf
العلاقة: https://vestnikramn.spr-journal.ru/jour/article/view/130/69Test; https://vestnikramn.spr-journal.ru/jour/article/view/130Test
الإتاحة: https://doi.org/10.15690/vramn.v68i11.851Test
https://doi.org/10.15690/vramn6811Test
https://vestnikramn.spr-journal.ru/jour/article/view/130Test -
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المؤلفون: D. V. Grishin, S. S. Aleksandrova, M. V. Pokrovskaya, I.Yu. Toropigin, M. A. Eldarov, Nikolay N. Sokolov, Alexander V. Veselovsky, Vadim S. Pokrovsky, D.D. Zdanov, Yu.A. Gladilina
المصدر: Biomedical Chemistry: Research and Methods; Vol. 2 No. 1 (2019); e00071
Biomedical Chemistry: Research and Methods; Том 2 № 1 (2019); e00071
Biomedical Chemistry: Research and Methodsمصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, chemistry.chemical_classification, biology, Metal ions in aqueous solution, Rhodospirillum rubrum, Mutant, L-asparaginase Rhodospirillum rubrum, site-directed mutagenesis, physical-chemical properties, L-аспарагиназа Rhodospirillum rubrum, сайт-направленный мутагенез, физико-химические свойства, biology.organism_classification, 01 natural sciences, Amino acid, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, EXPERIMENTAL RESEARCH, chemistry, Biochemistry, 010608 biotechnology, Urea, Denaturation (biochemistry), Site-directed mutagenesis, Peptide sequence
وصف الملف: text/html; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaedc62588b6b23f9f06922ed9d8dfaTest
http://www.bmc-rm.org/index.php/bmcrm/article/view/71Test -
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مصطلحات موضوعية: ÑеÑвеÑÑиÑÐ½Ð°Ñ ÑÑÑÑкÑÑÑа, ÑкÑининг ÑÑловий кÑиÑÑаллизаÑии, наÑивнÑй ÑлекÑÑоÑоÑез, CN-PAGE, ÑайÑ-напÑавленнÑй мÑÑагенез, heterologous expression, quarternery structure, CTD, Ñигма-1 ÑеÑепÑоÑ, ÑиÑоплазмаÑиÑеÑкий домен, sigma-1 receptor, геÑеÑологиÑеÑÐºÐ°Ñ ÑкÑпÑеÑÑиÑ, site-directed mutagenesis, crystallization screen
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4db424de03bd29c5008ac5933b46e98fTest
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المؤلفون: Vladimir I. Tishkov, S. S. Savin, K. V. Ryzhenkova, I. V. Golubev, Natalia Komarova, T. A. Chubar
المصدر: Scopus-Elsevier
Acta Naturaeمصطلحات موضوعية: chemistry.chemical_classification, substrate specificity, Mutant, D-amino acid oxidase from yeast Trigonopsis variabilis, D-amino acid oxidase, hydrophobization of alpha-helices, protein engineering, Biology, Biochemistry, thermal stability, Yeast, Amino acid, Serine, Enzyme, chemistry, D-AMINO ACID OXIDASE FROM YEAST TRIGONOPSIS VARIABILIS,PROTEIN ENGINEERING,HYDROPHOBIZATION OF ALPHA-HELICES,ITE-DIRECTED MUTAGENESIS,UBSTRATE SPECIFICITY,HERMAL STABILITY, Molecular Medicine, site-directed mutagenesis, Site-directed mutagenesis, Molecular Biology, Alpha helix, Research Article, Biotechnology
وصف الملف: text/html
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5283efd14e7b6a67167025505a8cb64Test
http://cyberleninka.ru/article_covers/15652809.pngTest