POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
| العنوان: | POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS |
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| المؤلفون: | A. V. Sosnov, S. V. Sadovnikov, F. M. Semchenko, K. A. Rufanov, V. N. Tohmahchi, A. A. Sosnova, I. A. Tyurin |
| المصدر: | Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 196-206 (2019) |
| بيانات النشر: | LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | nervous system, severe and moderate pain, lead compounds, biotargets of nervous system, ion channel blocker, HD9665-9675, potent non-narcotic analgesic, Pharmaceutical industry, tetrodotoxin |
| الوصف: | The article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of pharmaceuticals. Their application is very important as an alternative to opiates. However, the actual number of drug candidates is very limited. As a result of the authors analysis one of the most potent non-narcotic analgesics (PNS neurons sodium channel blocker) - Tetrodotoxin (TTX) was recognized as the most promising. Currently FSUE «GosZMP» conducting preclinical studies of injectable preparation of TTX. |
| اللغة: | Russian |
| تدمد: | 2658-5049 2305-2066 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doajarticles::32408a28ea4370f341a733a1b7d22015Test https://www.pharmjournal.ru/jour/article/view/241Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doajarticles..32408a28ea4370f341a733a1b7d22015 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26585049 23052066 |
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