LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS
| العنوان: | LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS |
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| المؤلفون: | Yoshiaki Takayama, Shuichi Ichikawa |
| المصدر: | Российский кардиологический журнал, Vol 0, Iss 3, Pp 33-39 (2011) |
| بيانات النشر: | «FIRMA «SILICEA» LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Physiology, Diastole, Tetrazoles, Blood Pressure, olmesartan, Plasma renin activity, Renin-Angiotensin System, Angiotensin Receptor Antagonists, chemistry.chemical_compound, Internal medicine, Renin, Renin–angiotensin system, Internal Medicine, Humans, Medicine, Diseases of the circulatory (Cardiovascular) system, Pulse, Aldosterone, Antihypertensive Agents, Aged, Olmesartan Medoxomil, Angiotensin II receptor type 1, business.industry, Angiotensin II, Imidazoles, Middle Aged, Respiration Disorders, angiotensin ii receptor antagonists, Endocrinology, Blood pressure, renin-angiotensin-aldosterone system, chemistry, RC666-701, Hypertension, Female, Angiotensin I, Cardiology and Cardiovascular Medicine, business, Olmesartan, medicine.drug |
| الوصف: | The object of this study is to evaluate the long-term effects of olmesartan on hypertension and the renin-angiotensin-aldosterone system in hypertensive patients. This study evaluated 26 hypertensive male and female outpatients, 38-69 years of age, with a systolic blood pressure > or = 160 mmHg and/or a diastolic blood pressure > or = 95 mmHg. Oral doses of 5 to 40 mg olmesartan were administered once daily. Blood pressure and renin-angiotensin-aldosterone parameters (plasma renin activity and plasma angiotensin I, II, and aldosterone concentrations) were evaluated at 12-16 weeks, 6 months, and 1 year after the start of olmesartan administration. Systolic and diastolic blood pressures were significantly decreased following the administration of olmesartan. The observed decreases in systolic and diastolic blood pressures after 1 year of treatment were 28.8+/-2.1 mmHg and 15.8+/-1.3 mmHg, respectively. No change was observed in the pulse rate. The plasma renin activity increased significantly from a baseline premedication mean of 1.26+/-0.31 ng/ml/h to a mean of 2.58+/-0.74 ng/ml/h and 2.87+/-0.72 ng/ml/h after 6 months and 1 year of treatment, respectively. Angiotensin II levels decreased significantly from a baseline of 20.4+/-3.2 pg/ml to a mean of 8.6+/-2.1 pg/ml and 6.8+/-1.8 pg/ml after 6 months and 1 year of treatment, respectively. The plasma aldosterone level also decreased significantly after 6 months of treatment. In hypertensive patients, the long-term administration of olmesartan, a novel AT1 receptor antagonist, decreased both blood pressure and plasma angiotensin II levels. |
| اللغة: | Russian |
| تدمد: | 2618-7620 1560-4071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0e03061c283da5f0fea05ea222c4ceTest https://russjcardiol.elpub.ru/jour/article/view/1105Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4e0e03061c283da5f0fea05ea222c4ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26187620 15604071 |
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