التفاصيل البيبلوغرافية
| العنوان: |
Bone marrow involvement: Atypical presentation of early-onset childhood sarcoidosis. |
| المؤلفون: |
Meshram, Rajkumar M.1, Gajimwar, Vishal S.1, Gholap, Siddhant1, Jhanwar, Madhuri1 |
| المصدر: |
European Journal of Rheumatology. Oct2020, Vol. 7 Issue 4, p190-194. 5p. |
| مصطلحات موضوعية: |
*SARCOIDOSIS, *MULTINUCLEATED giant cells, *BONE marrow, *ETIOLOGY of diseases, *UVEITIS, *EOSINOPHILS |
| مصطلحات جغرافية: |
INDIA |
| مستخلص: |
Childhood sarcoidosis is a chronic multisystemic, non-caseating granulomatous disease of unknown etiology. Early-onset disease classically presents with a triad of skin rash, uveitis, and arthritis, but bone marrow involvement is rare. We report a 9-1/2- year old Indian female child who presented with bleeding manifestation, skin rash, uveitis, and arthritis. Bone marrow biopsy showed multiple non-necrotizing granulomas comprising epithelioid cells, mature lymphocytes, and multinucleated giant cells with few eosinophils in the background, with negative staining for acid-fast bacilli or fungi. She was treated successfully with oral prednisolone. This is the first report of an early-onset childhood sarcoidosis with bone marrow involvement from India. [ABSTRACT FROM AUTHOR] |
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