التفاصيل البيبلوغرافية
| العنوان: |
هطخصِیاتی فیضیکَ ضیویایی ًاًَ حاهلّای رسات کیتَصاى پش ضذُ تاتتاسیکلَدکستشیي/هضاالصیي: فشآیٌذ آصادساصی داسٍ ٍ افضایص خاصیت آًتیاکسیذاًی. (Persian) |
| العنوان البديل: |
Physicochemical Characterization of Chitosan-Filled Nanocarriers of BetaCyclodextrin / Mesalazine: Drug Release Process and Enhancement of Antioxidant Properties. (English) |
| المؤلفون: |
ٗ شيٚ ًبٍدٍٞ, ، ٛيٜب ػٔيِاىٟ |
| المصدر: |
Knowledge & Health / Dānish va Tandurustī; 2022, Vol. 17 Issue 1, p18-30, 13p |
| مصطلحات موضوعية: |
CYCLODEXTRINS, INCLUSION compounds, ANTI-inflammatory agents, MESALAMINE, CHITOSAN |
| مستخلص: |
Introduction: Mesalazine (MSZ, 5-amino-2-hydroxybenzoic acid is an anti-inflammatory drug that is commonly used to treat mild to moderately active ulcerative colitis,This study aimed to develop a novel sustained release system for mesalazine (MSZ) by preparing β-cyclodextrin (β-CD) inclusion complex loaded chitosan (CS) nanoparticles (NPs). Methods: Complexes of MSZ with modified β-CD was prepared by chitosan nanoparticles (CS). and characterized by using UV-Vis, FT-IR, SEM and 1HNMR. Calculations of the relationships of the formation of modified complexes and their application were performed using UV-vis spectroscopic data analysis. Results: Phase-solubility analysis showed AL-type diagram with beta-CD,. according to the Higuchi and Connors method, is Kstab= 696.462 M− 1 . The in vitro tests showed that the formation of the inclusion complex increase in the 2,2-diphenyl1-picrylhydrazyl (DPPH) radical-scavenging capacity compared to the free MSZ at the same concentration. Conclusion: The results revealed that Under the optimized parameters, the resultant MSZ/β-CD-CS NPs were found to be nano-spheres with small particle size and high drug loading efficiency. Conclusively, the MSZ/β-CD-CS NPs exhibited vast potential for developing novel delivery system of MSZ with a sustainedrelease profile. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
