Microinjection of Orexin-A into the Locus Coeruleus Area Induces Morphine Withdrawal Behaviors in Morphine Independent Rats
| العنوان: | Microinjection of Orexin-A into the Locus Coeruleus Area Induces Morphine Withdrawal Behaviors in Morphine Independent Rats |
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| المؤلفون: | Hosin Azizi, Atefeh Hadian, Saeed Semnanian |
| المصدر: | Research on Addiction, Vol 5, Iss 20, Pp 105-117 (2012) |
| بيانات النشر: | Drug Control Headquarters, Research and Education Office, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Orexin-A, lcsh:Therapeutics. Pharmacology, lcsh:Psychology, nervous system, digestive, oral, and skin physiology, mental disorders, Morphine Withdrawal Syndrome, lcsh:RM1-950, lcsh:BF1-990, Locus Coeruleus, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes |
| الوصف: | Introduction: Orexin neuropeptide has a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the Locus Coeruleus (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. LC neurons do not show withdrawal-induced hyperactivity in brain slices from morphine-dependent rats. Thus, it has been suggested that the increase in LC neuronal activity seen in vivo is mediated by extrinsic factors. Therefore, this study was carried out to find whether LC microinjection of orexin-A can induce withdrawal behaviors. Method: Adult male Wistar rats were used in this study. Intra-LC microinjection of orexin-A or orexin-A vehicle was performed one week after LC cannulation. Thereafter, somatic signs of withdrawal were evaluated during a period of 25 min.Findings: Orexin-A induced several signs of morphine withdrawal. Conclusion: It may be concluded that orexin at LC acts as an extrinsic factor in the expression of morphine withdrawal syndrome. |
| اللغة: | Persian |
| تدمد: | 2423-6535 2008-4307 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doajarticles::399f66328da98c296b55b5d5f81046beTest http://www.etiadpajohi.ir/browse.php?a_code=A-10-372-57&slc_lang=en&sid=1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doajarticles..399f66328da98c296b55b5d5f81046be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24236535 20084307 |
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