Evaluation of Cold allodynia by Thermal Place Preference Test Following A Short Term of Treadmill Exercise in Neuropathic Rats
| العنوان: | Evaluation of Cold allodynia by Thermal Place Preference Test Following A Short Term of Treadmill Exercise in Neuropathic Rats |
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| المؤلفون: | Hatef Khosravi, Farzin Azarpey, Gholamreza Vafaie Sayah, Emad Khalilzadeh, Reza Hazrati, Mahdi Dolatyari |
| المصدر: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 26, Iss 2, Pp 155-171 (2018) |
| بيانات النشر: | Ilam University of Medical Sciences, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, lcsh:R5-920, business.industry, lcsh:R, lcsh:Medicine, Treadmill exercise, Term (time), rats, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Physical medicine and rehabilitation, Allodynia, opioidergic systems, Preference test, medicine, neuropathy, medicine.symptom, thermal place preference, business, lcsh:Medicine (General), 030217 neurology & neurosurgery, moderate aerobic exercise |
| الوصف: | Introduction: In this study, we investigated the hypothesis of whether short term and moderate intense treadmill exercise could lead to a sustained reversal of peripheral neuropathy induced cold aversion by activation of endogenous opioidergic systems. Materials & Methods: The tibial nerve transection (TNT) was performed in the anesthetized rats. 28 days after TNT surgery, the animals were randomized to three sedentary and four treadmill exercise (14 days, 30 min/day with max speed of 1.2 Km/h) groups. Animal activity and thermal preference behavior were determined by double plate technique (thermo-neutral plate: 24 ºC and cold plate: 14 ºC), equipped with a video tracking software. For determination of opioidergic system involvement, intraperitoneal injection of naltroxone (2 mg/kg) was done before exercise. Morphine (2.5 mg/kg) and naloxone (1 mg/kg) were also used exactly after the end of the last session of exercise. Findings: Tibial nerve transection significantly decreased the animals’ activities (P |
| اللغة: | Persian |
| تدمد: | 2588-3135 1563-4728 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed121af273dd5291c00d59510aae42faTest http://sjimu.medilam.ac.ir/browse.php?a_code=A-10-3530-1&slc_lang=en&sid=1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ed121af273dd5291c00d59510aae42fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25883135 15634728 |
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