التفاصيل البيبلوغرافية
| العنوان: |
Transthyretin constitutes a functional component in pancreatic β-celI stimulus--secretion coupling. (English) |
| المؤلفون: |
Refai, Essam, Dekki, Nancy, Shao-Nian Yang, Imreh, Gabriela, Cabrera, Over, Lina Yu, Guang Yang, Norgren, Svante, Rössner, Sophia M., Inverardi, Luca, Ricordi, Camillo, Olivecrona, Gunilla, Andersson, Mats, Jörnvall, Hans, Berggren, Per-Olof, Juntti-Berggren, Lisa |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 11/22/2005, Vol. 102 Issue 47, p17020-17025, 6p |
| مصطلحات موضوعية: |
PANCREATIC beta cells, BLOOD plasma, BIOLOGICAL transport, GLUCOSE, CARRIER proteins, HYPOGLYCEMIC agents |
| مستخلص: |
Transthyretin (TTR) is a transport protein for thyroxine and, in association with retinol-binding protein, for retinol, mainly existing as a tetramer in vivo. We now demonstrate that TTR tetramer has a positive role in pancreatic β-cell stimulus-secretion coupling. TTR promoted glucose-induced increases in cytoplasmic free Ca²+ concentration ([Ca²+]i) and insulin release. This resulted from a direct effect on glucose-induced electrical activity and voltage- gated Ca²+ channels. TTR also protected against β-cell apoptosis. The concentration of TTR tetramer was decreased, whereas that of a monomeric form was increased in sera from patients with type 1 diabetes. The monomer was without effect on glucose-induced insulin release and apoptosis. Thus, TTR tetramer constitutes a component in normal β-cell function. Conversion of TTR tetramer to monomer may be involved in the development of β-cell failure/ destruction in type 1 diabetes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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