دورية أكاديمية
Functional heterogeneity of HLA-A*02 subtypes revealed by presentation of a MAGE-3-encoded peptide to cytotoxic T cell clones.
| العنوان: | Functional heterogeneity of HLA-A*02 subtypes revealed by presentation of a MAGE-3-encoded peptide to cytotoxic T cell clones. |
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| المؤلفون: | Fleischhauer, K, Tanzarella, S, Russo, V, Sensi, M L, van der Bruggen, Pierre, Bordignon, C, Traversari, C |
| المساهمون: | UCL - SSS/DDUV - Institut de Duve |
| المصدر: | Journal of Immunology, Vol. 159, no. 5, p. 2513-21 (1997) |
| بيانات النشر: | American Association of Immunologists |
| سنة النشر: | 1997 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | Antigen Presentation, Neoplasm Proteins, Neoplasms, Patient Selection, Peptide Fragments, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, Cytotoxic, Transfection, Antigens, Neoplasm, Cell Line, Transformed, Cytotoxicity, Immunologic, Gene Rearrangement, T-Lymphocyte, HLA-A2 Antigen, Humans, Immunotherapy, Melanoma |
| الوصف: | The peptide-binding and presentation characteristics of seven naturally occurring HLA-A2 subtypes were studied using M3(271), a peptide derived from the tumor-specific Ag encoded by gene MAGE-3, which has been shown to be processed and presented by A*0201+ melanoma lines. Three independent M3(271)-specific CTL clones were obtained from two unrelated A*0201+ donors. B lymphoblastoid cell lines (BLCLs) expressing A*0201, A*0207, or A*0209 could be sensitized to lysis by all three clones upon incubation with the relevant peptide. Furthermore, the same BLCLs were able to present endogenous M3(271) in IFN-gamma release assays. These findings demonstrate, for the first time, the existence of a functional overlap between A*0207 and other A*02 subtypes. One of the CTL clones also lysed M3(271)-pulsed BLCLs expressing A*0204 and A*0206, while the other two clones recognized M3(271) only in the context of either of these two subtypes. Peptide-pulsed BLCLs expressing A*0202 or A*0205 were not lysed, although A*0205 and, with lower affinity, A*0202 molecules were shown to bind peptide M3(271). These findings have implications for the selection of cancer patients for specific immunotherapy with peptide M3(271). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | Ndonga |
| تدمد: | 0022-1767 1550-6606 |
| العلاقة: | boreal:141112; http://hdl.handle.net/2078.1/141112Test; info:pmid/9278345; urn:ISSN:0022-1767; urn:EISSN:1550-6606 |
| الإتاحة: | http://hdl.handle.net/2078.1/141112Test |
| رقم الانضمام: | edsbas.F60F6D52 |
| قاعدة البيانات: | BASE |
| تدمد: | 00221767 15506606 |
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