التفاصيل البيبلوغرافية
| العنوان: |
نقش میکروبیوتای روده در بروز عالئم رفتاری ناشی از تجویز مزمن مورفین در موشهای بزرگ آزمایشگاهی. (Persian) |
| العنوان البديل: |
The role of intestinal microbiota in the occurrence of behavioral symptoms caused by chronic administration of morphine in rats. (English) |
| المؤلفون: |
گین سعیدی, گس حسینمردی, مهیار جاناحمدی, ژیال بهزادی, فرشته پورعبدالح&, مسعود داداشی |
| المصدر: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p60-60, 2p |
| مصطلحات موضوعية: |
MORPHINE, NALOXONE, NEUROLOGICAL disorders, FECES, GUT microbiome |
| مستخلص: |
Introduction: The importance of the gut-brain axis has been identified in numerous neurological disorders. In recent years, the effect of gut microbiota on the nervous system has been noticed. The population of gut microorganisms can be effective in reward systems and side effects of drug abuse. Deaths resulting from drug use, particularly opioids used for pain management, are due to dependence. Prescribing opioids and experiencing opioid withdrawal can lead to dysbiosis, which is a change in the population of gut microbiota. Considering the effect of gut microbiota on the nervous system, adjusting the population of gut microbiota can be effective in preventing opioid painkiller complications in the nervous system. Methods: To transfer the gut microbiota from saline-treated animals to morphine-treated animals, donor animals are first treated with saline for 9 days. Then, 200mg fecal matter from the donor animals was collected, dissolved in PBS, and filtered and centrifuged before being given to the recipient animals ml of the suspension was administered to recipient animals by gavage 7 days before morphine treatment. During treatment, the animals were administered the same dose every 24 hours for nine days. On the 10th day, the symptoms of withdrawal syndrome induced by intraperitoneal injection of 1.5 mg/kg naloxone were assessed. Results: Naloxone injection in morphine-treated animals causes withdrawal symptoms such as activity, chewing, head tremor, penis licking, ptosis, rearing, scratching, and sniffing. Recolonizing the microbiota of animals treated with saline in the intestine of animals receiving subcutaneous morphine reduces activity, chewing, head tremor, rearing, and scratching. Conclusions: Dysbiosis can be one of the mechanisms involved in the development of morphine dependence. Recolonizing the gut microbiota and correcting dysbiosis due to morphine consumption can alleviate withdrawal symptoms. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
