التفاصيل البيبلوغرافية
| العنوان: |
تأثیر سیتیکولین بر فعالیت ضد افسردگی سیتالوپرام در موشهای کوچک سفید نر آزمایشگاهی. (Persian) |
| العنوان البديل: |
Title: Influence of Citicoline on antidepressant activity of Citalopram in male mice. (English) |
| المؤلفون: |
مهتاب روحی عزیزی, محمدرضا زریندست, آناهیتا ترکمان ب, شاهین آخوندزاده, علیاکبر نجاتی صف |
| المصدر: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p728-728, 1p |
| مصطلحات موضوعية: |
CYTIDINE diphosphate choline, ANTIDEPRESSANTS |
| مستخلص: |
Introduction: Depression is one of the big challenges of 21th century as a wide spread mental disorder, which can leads from exposure to chronic stressful environment events. Prescribing complementary drugs can be one of the most important clinical strategies during the treatment process of patients suffering from depression in order to reduce the main dose of antidepressants and to increase its effects. Although citalopram, as a safe and selective serotonin reuptake inhibitor, has fewer side effects than other antidepressants, in order to strengthen its effect, reduce the dosage and therefore its possible side effects in the long term, it is necessary to prescribe an effective auxiliary drug. In this study, we assessed the probability effect of citicoline on antidepressant effect of citalopram. Methods and Materials: Chronic unpredictable mild stress (CUMS), a behavioral model of paradigm, was used as a well-validated rodent’s model of depression for 21 days. Mice were under treatment by citalopram or/and citicoline. The antidepressant effects of drugs were measured by three depression tests i.e. sucrose preference test, open field test and forced swimming test. Results: The co-administration of ineffective doses of both drugs resulted in significant antidepressant effects (increased sucrose consumption, increased locomotor activity and increased swimming behavior following a decrease in immobility duration) in all conducted behavioral tests. Conclusion: Our findings suggest that citicoline can be used as a supplementary drug to citalopram in treatment plan of depression in animals. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
