دورية أكاديمية
Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report
| العنوان: | Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report |
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| المؤلفون: | Amélie Giudicelli-Bailly, Chiara Della Badia, Marc Augsburger, Hervé Quintard, Raphaël Giraud, Pia De Stefano |
| المصدر: | Journal of Neurocritical Care, Vol 16, Iss 1, Pp 46-50 (2023) |
| بيانات النشر: | The Korean Neurocritical Care Society, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | pentobarbital, status epilepticus, nonconvulsive status epilepticus, ictal–interictal continuum, forensic science, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background Barbiturate poisoning is rare but potentially fatal. Case Report We reported a case of barbiturate poisoning in a 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning. The initial blood pentobarbital concentration was 61 mg/L, corresponding to a potentially lethal dose. Despite the ingestion of a high dose of pentobarbital, the electroencephalogram revealed an unattended pattern compatible with possible nonconvulsive status epilepticus. Following resuscitation maneuvers, appropriate care, and antiseizure medication, the patient awakened after 7 days. The evolution was excellent without neurological deficits at 2 months. Conclusion Despite the expected and known effects of high-dose pentobarbital in reducing and suppressing cortical activity in the brain, the present case demonstrates that lethal dose of pentobarbital may have an epileptogenic effect. Our hypothesis was that the mechanism of the origin of such a picture is a relatively abrupt decrease in toxic doses of pentobarbital, resulting in a withdrawal phenomenon. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2005-0348 2508-1349 |
| العلاقة: | http://e-jnc.org/upload/pdf/jnc-230019.pdfTest; https://doaj.org/toc/2005-0348Test; https://doaj.org/toc/2508-1349Test |
| DOI: | 10.18700/jnc.230019 |
| الوصول الحر: | https://doaj.org/article/3876bf23a2cf484fa4f4a445d9664d19Test |
| رقم الانضمام: | edsdoj.3876bf23a2cf484fa4f4a445d9664d19 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20050348 25081349 |
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| DOI: | 10.18700/jnc.230019 |